Canadian Health Measures Survey (CHMS) Biobank Joanne Boisjoli Health Statistics Division Statistics Canada 1 Statistics Canada Statistique Canada

CHMS BIOBANK: BACKGROUND Statistics Canada Statistique Canada 2  Blood and urine samples from consenting respondents are stored for future studies.  DNA collected from consenting respondents aged 14 to 79 years. We will be expanding to 3 to 79 years in next survey cycle beginning in  Information on purposes of storage, access and right to withdraw is provided to respondents prior to collection.  The National Microbiology Laboratory in Winnipeg is the biorepository (Biobank) for long-term storage of biospecimens.  Invaluable but finite (non-renewable) source of information.

CHMS BIOBANK WEBSITE Statistics Canada Statistique Canada 3  Search engine: type in “CHMS Biobank”  What’s available?  Access Requirements  Application Form for the Biobank  List of approved studies  Call for proposals twice each year (spring and fall)

WHAT’S AVAILABLE? MatrixAge RangeVolume Serum3 to 79 years0.5 mL and 1.0 mL Plasma3 to 79 years0.5 mL Whole Blood3 to 79 years0.8 mL and 1.0 mL Urine3 to 79 years1.0 mL and 4.5 mL DNA14 to 79 years1 µg Statistics Canada Statistique Canada 4 Detailed list at this link:

 Proposal application submitted to CHMS Biobank  Feasibility assessment by CHMS Staff  Biobank Advisory Committee 4 Federal members 4 External members (academics)  Statistics Canada’s senior management  Key points Proof of Funding Research Ethics Board approval Security Clearance – facility and personnel Statistics Canada Statistique Canada 5 STEPS FOR ACCESS

COSTS  Samples available on cost recovery basis: 2 ml serum, plasma, whole blood: $44,000 per series DNA plates: $44,000 per series 5 ml urine: $48,000 per series  a “series” is a collection from one survey cycle.  includes costs such as administration, lab contracting fees, packaging and shipping samples, processing and validation of data  RDC access costs are generally included but not always.  costs are estimates only; if multiple series are requested, the cost may be prorated to reflect that some processes need only be done once for each project. Cost per series could increase if multiple labs are involved in the analysis. Statistics Canada Statistique Canada 6

ANALYTICAL CONSIDERATIONS  Confidentiality rules prohibit release of results where the cell size is too small.  If the predicted number of results will be too small (less than 10 if bootstrap weights are used) then the study cannot produce usable results. Statistics Canada reviewers will provide feedback to researchers on this at the feasibility assessment phase.  Examples: A project which is looking for a significant, but low frequency target can be limited in the number of comparisons due to the limitation of cell size. Similarly analysis which is looking for comparisons using low frequency variables could also have limitations. Although data on ethnicity is gathered by the CHMS, the individual ethnic groups are comparatively low in number. To go into a lot of detail on ethnicity would need data from many cycles.  CHMS Biobank collection is designed to produce national estimates. Requests for subsamples would need justification Statistics Canada Statistique Canada 7

OTHER THINGS TO KNOW Statistics Canada Statistique Canada 8  As with other Statistics Canada data, confidentiality and physical security requirements must be satisfied  Documents further explaining security requirements available upon request.  Multi-step access and approval process Expect several months from the time proposal is submitted until study can begin.  Biobank specimens not to be used to validate methods. Methods are expected to be developed and validated when proposal is submitted. SOPs will be requested.  Analysis of data is only available at a Statistics Canada Research Data Centre (RDC). Lab data from the project can only be linked to other CHMS data at RDCs  Exclusive access to data file for 12 to 18 months before file becomes available to other researchers in RDCs.

CURRENT STATUS  First biobank project will be publishing results later this year.  Project studying “The modifying effect of genetic polymorphisms involved in folate and B12 metabolism on the relationship between folate/B12 intake and vitamin status”  will be releasing a data file containing results from 116 markers related to folate and B12 metabolism.  Two more projects have been fully approved Analysis will start later this year  Two other projects still going through approval process Funding, REB approval, Biobank Advisory Committee follow-up  Call for proposals launched for May and June 2015

Statistics Canada Statistique Canada 10 For more information on the CHMS Biobank:  Some survey documents only available upon request Search engine: type in “CHMS Biobank”

Statistics Canada Statistique Canada 11 QUESTIONS?