ADAMED Laboratorios SLU * Dedicated in body and mind

“Instead of a passive waiting for what future will bring us, we belive in a possibility of creating it. From the very beggining… This philosophy has been inspiring us till now. We hope it will be also yours from tomorrow.”

Adamed Spain – “a dream come true” ADAMED Laboratorios S.L.U. (Spain) is going to be a dynamic and innovative pharmaceutical company focus on CNS specialists an CNS pathologies in order to create add- value services and high quality products that represents a benefit for population. the words (october 2008) OBJECTIVES:

Adamed Spain Young company (average experience: 12 years in Spanish Market) R&D Support of Adamed Poland Innovative beyond products…specialist and patients contacts Specialized in SNC specialists (complicate Area) Gives high quality solutions Dynamic and Flexible Focused but with expansion expectations Characteristics:

Adamed Spain – “a dream come true” Specialized in Specialist: Focus on CNS specialists (psychiatrist and neurologist) focus on: – Schizophrenia Units – Bipolar Disease Units – Addictions Units – Parkinson Units Our identity: quality and add-value services – Products manufactured in Europe – Closing work with Scientific societies, be a referent on CNS market FACTS:

Adamed Products PRODUCTMOLECULELAUNCH DATE Topiramate (Antiepileptic drug) April 2009 Quetiapine (Antipsychotic drug) April 2009 Lamotrigine (Antiepileptic- Mood Stabilaser) June 2009 Venlafaxine (Dual Antidepressant) May 2009 Pramipexol e (Antiparkinsonian drug) Sept Clozapine (Antipsychotic drug) March 2011 Olanzapine (Antipsychotic drug) 25 th of April 2011

Adamed Evolution since launch 142% 151%

Adamed Spain – “a dream come true” Focus on CNS Specialist with a high positioning with the KOL of both societies. Recognised high-cooperation with Health Authorities pharma company Developing projects closed to medical societies: – Suicide Recommendations – SEP. SEPB- FEPSM – Fornes Project – Book for BD patients and family – Best in Class Awards for Neuro Specialist Awards received: – Launching Acomicil: Diario Médico – Book for BD patients and family FACTS:

Projects developed with CNS specialist Academia de Semiología “Recommendations for preventing and managing Suicidal behaviors” ACO-TEXT Trial: Evaluating adherence to treatment sending daily SMS to patients with addictions Neuro Best in Class Awards

Adamed launching Projects developed with CNS specialist

Strategic Plan Consolidate Adamed as a reference company for CNS Be a reference for the CNS specialists Support for patients and their families with information programs Simplicity and dynamism as a basis for the company strategy: – Working team – Pharma business, market and customer Knowledge – Value of well-done work Objectives:

Adamed Spain belongs to Adamed Group POLAND 1986 SPAIN (september 2008)

Some data… people working in Adamed Poland API, FP facilities (incl. Polfa and Agropharm adcquisitions) 25 patents 475 salesforce / 100 people working in R&D 150 M€ Polish market turnover after mergers / 20 M€ export sales Introduced in many areas: cardio, CNS, gastro, respi, OTC… New chemical entities: oncology, diabetes, CNS Philosophy: “From generic to innovative pharma”

History of innovation in Adamed PRIORITY AREAS OF OUR R &D: PRIORITY AREAS OF OUR R &D: Research of Innovative drugs Metabolic Diseases Metabolic Platform Cancer Diseases Oncology Platform Neuropsychiatry Platform CNS Diseases