Hematopoiesis Pharmacology Review 28 August :22 AM

Abciximab Antiplatelet Anti-GPIIb/IIIa receptor antibody

Acetaminophen Analgesic, Antipyretic

Adalimumab TNF inhibitor Anti-TNF antibody Used in rheumatoid arthritis

Alemtuzumab Antineoplastic Anti-CD52 antibody

Allopurinol Antigout Antineoplastic (supporting agent) Folic acid analogue Xanthine oxidase inhibitor

Aminocaproic acid (EACA) Procoagulant Inhibitor of plasminogen activation (decreases fibrinolysis)

Aminoglutethimide Antineoplastic Immunosuppressive Glucocorticoid antagonist Aromatase inhibitor (decreases steroid synthesis)

Angiostatin Antineoplastic Angiogenesis inhibitor

Anistreplase Thrombolytic Streptokinase + plasminogen

Anti-thymocyte globulin Immunosuppressive Anti-T cell antibody

Aprotinin Procoagulant Fibrinolytic inhibitor Serine protease inhibitor (“serpin”) Streptokinase inhibitor

Argatroban Anticoagulant Direct thrombin inhibitor

L-asparaginase Antineoplastic Protein synthesis inhibitor

Aspirin (Acetylsalicylic acid, ASA) NSAID (acetylsalicylate) Analgesic, Anti-inflammatory Antipyretic, Antiplatelet Irreversible cyclooxygenase inhibitor

Azathioprine Immunosuppressive Antineoplastic Antimetabolite (“pseudofeedback inhibition” of HGPRT and PRP)

Basiliximab Immunosuppressive Anti-CD25 (interleukin 2 receptor) Organ transplant (antirejection)

Betamethasone Adrenocorticosteroid Glucocorticoid Anti-inflammatory steroid Not by inhalation

Bivalirudin Anticoagulant Direct thrombin inhibitor

Bortezomib Antineoplastic Proteosome inhibitor

Bradykinin Inflammatory mediator Plasma, hypotension, pain

C3a, C5a Inflammatory mediators Anaphylatoxins Low molecular weight complement cleavage products

Celecoxib NSAID Anti-inflammatory Cyclooxygenase 2 (COX-2) inhibitor

Cetirizine Antihistamine H 1 antagonist Non-sedating

Chlorpheniramine Classical antihistamine H 1 antagonist

Clopidogrel Antiplatelet ADP receptor antagonist

Cobalamin (cyanocobalamin, hydroxocobalamin) Vitamin Treatment for vitamin B12 deficiency

Cortisol (Hydrocortisone) Adrenocorticosteroid Glucocorticoid Anti-inflammatory steroid

Cyclosporine Immunosuppressive Antineoplastic Binds cyclophilin Inhibits calcineurin

Cytarabine (AraC) Antineoplastic Antimetabolite

Daclizumab Immunosuppressive Anti-CD25 (interleukin 2 receptor) antibody Organ transplant (anti-rejection)

Dalteparin Anticoagulant LMW Heparin ATIII activator

Desmopressin acetate Synthetic analogue of arginine vasopressin Used in treatment of bleeding disorders

Dexamethasone Adrenocorticosteroid Glucocorticoid Antineoplastic Antiemetic Anti-inflammatory steroid Not by inhalation

Diflunisal NSAID Analgesic, Anti-inflammatory Antipyretic Cyclooxygenase inhibitor

Diphenhydramine Classical antihistamine Antiemetic H 1 antagonist

Dipyridamole Antiplatelet Phosphodiesterase inhibitor (increases cAMP)

Drotrecogin alfa (Activated Protein C) Anticoagulant Many actions Treatment for septic shock

Edrecolomab Antineoplastic Anti-17-1A antibody

Enoxaparin Anticoagulant LMW Heparin ATIII activator

Eptifibatide Antiplatelet GPIIb/IIIa antagonist

Erythropoietin (EPO) Cytokine Primary regulator of RBC synthesis

Etanercept TNF inhibitor Tumor necrosis factor receptor + F c portion of IgG Used in rheumatoid arthritis

Fexofenadine Antihistamine H 1 antagonist Non-sedating

5-Fluorouracil Antineoplastic Antimetabolite Thymidylate synthase inhibitor

Folic acid Vitamin Treatment for folic acid deficiency

Gefitinib Antineoplastic Miscellaneous Tyrosine kinase inhibitor

Gemcitabine Antineoplastic Antimetabolite

Gemtuzumab Antineoplastic Anti-CD33 antibody

Heparin Anticoagulant ATIII activator

Hirudin Anticoagulant Direct thrombin inhibitor (DTI)

Histamine Inflammatory mediator Stored in mast cells and basophils

Hydrocortisone Adrenocorticosteroid Glucocorticoid Anti-inflammatory steroid

4-Hydroxycoumarin Oral anticoagulant Vitamin K synthesis inhibitor

Hydroxyurea Antineoplastic Miscellaneous Ribonucleotide reductase inhibitor

Hydroxyzine Classical antihistamine H 1 antagonist

Ibritumomab Antineoplastic Anti-CD20 antibody

Ibuprofen NSAID Analgesic, Anti-inflammatory Antipyretic Reversible cyclooxygenase inhibitor

Imatinib Antineoplastic Miscellaneous Tyrosine kinase inhibitor

Indomethacin NSAID Analgesic, Anti-inflammatory, Antipyretic Cyclooxygenase inhibitor Tocolytic Uterine relaxant

Infliximab TNF inhibitor Anti-TNF monoclonal antibody Treatment of IBD

Interferon alpha Antiviral for hepatitis Antineoplastic Cytokine Anti-angiogenesis

Interleukin 2 Cytokine Antineoplastic

Interleukin 11 Cytokine Antineoplastic (supporting agent)

Interleukin 12 Cytokine Antineoplastic (supporting agent)

Kallidin Inflammatory mediator Plasma, hypotension, pain

Ketoprofen NSAID Analgesic, Anti-inflammatory, Antipyretic Cyclooxygenase inhibitor

Lepirudin Anticoagulant Direct thrombin inhibitor (DTI)

Leucovorin Antineoplastic (supporting agent) Folic acid analogue (used in methotrexate rescue)

Leukotriene B 4 (LTB 4 ) Inflammatory mediator Lipoxygenase product of arachidonate metabolism Chemotactic

Leukotrienes C 4, D 4, E 4 (LTC 4, LTD 4, LTE 4 ) Inflammatory mediators Cysteinyl leukotrienes Peptidyl leukotrienes SRS-A Lipoxygenase products of arachidonate metabolism

Loratidine Antihistamine H 1 antagonist Non-sedating

Meclofenamate NSAID Analgesic, Anti-inflammatory, Antipyretic Cyclooxygenase inhibitor

6-Mercaptopurine Antineoplastic Antimetabolite (“pseudofeedback inhibition” of HGPRT and PRP – purine synthesis)

Methotrexate Immunosuppressive Antineoplastic Folic acid antagonist Dihydrofolate reductase inhibitor

Methylprednisolone Adrenocorticosteroid Glucocorticoid Anti-inflammatory steroid Not by inhalation

Montelukast Leukotriene inhibitor LTR1 and LTD4 antagonist Asthma treatment

Muromonab-CD3 Immunosuppressive Mouse monoclonal anti-CD3 antibody Organ transplant (anti-rejection)

Mycophenolate Immunosuppressive Inhibits inosine monophosphate dehydrogenase activity

Naproxen NSAID Analgesic, Anti-inflammatory, Antipyretic Cyclooxygenase inhibitor

Non-steroidal Anti-inflammatory Drugs (NSAIDs) Analgesic, Anti-inflammatory, Antipyretic Cyclooxygenase inhibitors

Omalizumab Anti-asthma Anti-IgE antibody

Palivizumab Antiviral Monoclonal antibody against the surface of respiratory syncytial virus

Pentostatin Antineoplastic Miscellaneous Enzyme inhibitor (blocks purine synthesis)

Phytonadione Vitamin K Warfarin antagonist

Piroxicam NSAID Analgesic, Anti-inflammatory, Antipyretic Cyclooxygenase inhibitor

Platelet Activating Factor (PAF) Inflammatory mediator Lipid Hypotensive

Prednisone Adrenocorticosteroid Glucocorticoid Antineoplastic Anti-inflammatory Not by inhalation

Promethazine Classical antihistamine Antipsychotic Antiemetic H 1 antagonist

Prostaglandin D 2 (PGD 2 ) Bronchoconstrictor Cyclooxygenase product of arachidonate metabolism

Prostaglandin E 2 (PGE 2 ) Dinoprostone (Dinoprost) Oxytocic prostaglandin Inflammatory mediator Cyclooxygenase product of arachidonate metabolism Uterine stimulant Cervical ripener

Prostaglandin F 2 (PGF 2 ) Inflammatory mediator Cyclooxygenase product of arachidonate metabolism

Prostaglandin I 2 (PGI 2 ) Inflammatory mediator Inhibits platelet aggregation Cyclooxygenase product of arachidonate metabolism Prostacyclin

Protamine Sulfate Heparin antagonist

Rituxumab Antineoplastic Anti-CD20 antibody

Rofecoxib NSAID Anti-inflammatory Cyclooxygenase 2 (COX-2) inhibitor

Sargramostim (GM-CSF) Colony stimulating factor WBC (granulocyte and macrophage) stimulant

Sirolimus Immunosuppressive Binds FKBP, inhibits mTOR (mammalian kinase target of rapamycin) & cell cycle progression Rapamycin

Streptokinase Thrombolytic

Sulindac NSAID Analgesic, Anti-inflammatory, Antipyretic Cyclooxygenase inhibitor

Tacrolimus Immunosuppressive Antineoplastic Binds FKBP (FK506 binding protein) Inhibits calcineurin

Thalidomide Antineoplastic Leprosy treatment Anti-angiogenic Anti-TNF 

6-Thioguanine Antineoplastic Antimetabolite (“pseudofeedback inhibition” of HGPRT and PRP – purine synthesis)

Thromboxane A 2 (TXA 2 ) Autacoid Promotes platelet aggregation Cyclooxygenase product of arachidonate metabolism

Ticlopidine Antiplatelet ADP receptor antagonist

Tissue plasminogen activators Thrombolytics alteplase, reteplase, tenecteplase

Tositumomab Antineoplastic Anti-CD20 antibody

Trastuzumab Antineoplastic Anti-HER2 antibody

Tripelennamine Classical antihistamine H 1 antagonist

Tumor necrosis factor  Cytokine Antineoplastic

Urokinase Thrombolytic

Warfarin Anticoagulant Vitamin K synthesis inhibitor

Zafirlukast Leukotriene inhibitor LTR 1 and LTD 4 antagonist Asthma treatment

Zileuton Leukotriene inhibitor 5-lipoxygenase inhibitor Used in asthma