Copyright © 2013, 2010 by Saunders, an imprint of Elsevier Inc. Chapter 73 Drug Therapy of Rheumatoid Arthritis.

Slides:



Advertisements
Similar presentations
Disease Modifying Anti-Rheumatic Drugs (DMARDs) Immunomodulatory and immunosuppresive Xenobiotic – Gold salts – Azathioprine – Methotrexate Biological.
Advertisements

NSAIDs 1 st line of therapy in the medical management of RA.
Hatem H Eleishi, MD Professor of Rheumatology, Cairo University Consultant Rheumatologist, Dr. Soliman Fakeeh Hospital Rheumatoid Arthritis Wednesday,
Copyright © 2013, 2010 by Saunders, an imprint of Elsevier Inc. Chapter 71 Cyclooxygenase Inhibitors: Nonsteroidal Anti-Inflammatory Drugs and Acetaminophen.
Therapy of children with juvenile idiopathic arthritis. New drug therapy Rik Joos, M.D. Centre for Paediatric Rheumatology University hospital, Gent, Belgium.
Biologics in psoriasis (2008) Dr. Amal Kokandi. What are biologics?  "biologics" are made from human or animal proteins. Biologics have been in use for.
תרופות בשימוש בראומטולוגיה פרופ. משה טישלר מחלקה פנימית ב והשרות הראומטולוגי בי " ח אסף הרופא צריפין.
DR.IBTISAM JALI MEDICAL DEMONSTRATOR
Scott Vogelgesang, MD Division of Immunology, Rheumatology and Allergy University of Iowa BIOLOGIC AGENTS: CURRENT AND FUTURE No conflicts of interest.
RHEUMATOID ARTHRITIS AND REHABILITATION
Arthritis Medications Part II Dr. Sherry Rohekar June 24, 2010.
Drugs used in joint diseases
Hot Topics in Rheumatology Prof. MG Molloy. Overview Rheumatoid Arthritis Psoriatic Arthritis Vasculitides: SLE Osteoarthritis Osteoporosis.
New Pharmacologic Treatment Options for Managing Rheumatoid Arthritis Devra Dang, Pharm.D. Department of Pharmacy National Institutes of Health.
Treatment of Rheumatoid Arthritis Then and Now
UC. Ulcerative Colitis ( UC ) Ulcerative colitis is an inflammatory bowel disease (IBD) that causes chronic inflammation of the digestive tract It is.
RHEUMATOID ARTHRITIS- FOR A HEALTHIER YOU ANGELA CARMER-HANSEN KAPLAN UNIVERSITY UNIT 4 HW499 PROFESSOR HENNINGSEN.
Disease –Modifying Antirheumatic Drugs ( DMARDs) Slow Acting Anti-inflammatory Drugs.
Interventions for Clients with Connective Tissue Disease and Other Types of Arthritis.
Copyright © 2013, 2010 by Saunders, an imprint of Elsevier Inc. Chapter 72 Glucocorticoids in Nonendocrine Disorders.
Cause of disability. Changes in the joint inflammation, proliferation of the synovium, errosion of cartilage & bones.
Musculoskeletal Medications Osteoporosis Rheumatoid Arthritis Gout Muscle Spasms.
Recomendations for the medicamentous treatment of chronic inflammatory rheumatic disease pain Dušan Logar Dpt.of Rheumatology, University Clinical Centre,
Disease –Modifying Antirheumatic drugs
1. Non-steroidal anti-inflammatory drugs (NSAIDs) 2. Glucocorticoids 3. Disease modifying anti-rheumatic drugs- DMARDs - imunosupressive effect -
Slow Acting Anti-inflammatory Drugs. DEFINITION Drugs used to relief pain & inflammation.
( Slow Acting Anti-inflammatory Drugs ). OBJECTIVES At the end of the lecture the students should Define DMARDs Describe the classification of this group.
Drugs used in inflammatory bowel disease and biological and immune therapy of IBD Prof. Hanan Hagar Pharmacology Department College of Medicine.
Lupus is an autoimmune disease where the body's immune system becomes hyperactive and attacks normal, healthy tissue. This results in symptoms such as.
Rheumatoid Arthritis (RA) By: Leon Richardson Period
Interventions for Clients with Connective Tissue Disease and Other Types of Arthritis.
Drugs used in inflammatory bowel disease and biological and immune therapy of IBD Profs. Alhaider and Hanan Hagar Pharmacology Department College of Medicine.
Slow Acting Anti-inflammatory Drugs ). BY PROF. AZZA EL-MEDANY DR. OSAMA YOUSF.
LSU Clinical Pharmacology
Approach to the Treatment of RA Try to figure out ‘what type’ of Rheumatoid Arthritis the patient has This is not a uniform disease Young, Sero-positive.
Understanding Rheumatoid Arthritis Randall J. Reed, MD Friday, November 13, :00 a.m. EST.
Rheumatoid Arthritis Dr Chandini Rao Consultant Rheumatologist.
Elsevier items and derived items © 2006 by Elsevier Inc. Interventions for Clients with Connective Tissue Disease and Other Types of Arthritis.
Universitatea de Medicina si Farmacia “Iuliu Hatieganu” Cluj-Napoca
( Slow Acting Anti-inflammatory Drugs ). OBJECTIVES At the end of the lecture the students should Define DMARDs Describe the classification of this group.
Dr. M Jokar RA - Definition u Chronic systemic inflammatory disorder u Unknown etiology u Synovium affected u Joint Deformity u Extra-articular.
PYRAMID POINTS CHAPTER 68: MUSCULOSKELETAL MEDICATIONS.
Dr.B.V.Venkataraman Professor in Pharmacology International Medical School Faculti Perubatan, New BEL Rd Bangalore Drugs.
BY PROF. AZZA EL-MEDANY DR. OSAMA YOUSIF General Features & Conditions to use antirheumatic Low doses are commonly used early in the course of the disease.
Disease modified Anti-rheumatic drugs ( DMARD)
Rheumatoid Arthritis Christine Aranyi and Rebecca Boon State university of new york institute of technology Pathophysiolog y Rheumatoid Arthritis (RA)
Advances in the Treatment of Crohn’s Disease GASTROENTEROLOGY 2004;126:1574–1581.
Coexistence of BEonchiectasis and Rheumatoid Arthritis 장 나 은 Maria M Wilczynska MRCP, Alison M Condliffe PhD FRCP, and Damian J McKeon PhD FRCP.
Elsevier Inc. items and derived items © 2010 by Saunders, an imprint of Elsevier Inc. Glucocorticoids in Nonendocrine Diseases.
Disease Modifying Antirheumatic drugs. At the end of the lecture the students should: Know the pathogenesis of rheumatoid joint damage Emphasize the rational.
Rheumatoid Arthritis: Treatment options in 2017
DMARDs Disease-Modifying Anti rheumatic Drugs
Rheumatoid Arthritis: Management and New Therapies
Drugs for Bone and Joint Disorders
Treatment Goal of treatment reduce inflammation and pain
Epidemiology of rheumatoid arthritis
My Treatment Approach to Rheumatoid Arthritis
Recommendations for the treatment of established RA (disease duration 6 month or longer). Biologic, biological originator DMARD or boDMARD; DMARD, disease-modifying.
Biologic Response–Modifying and Antirheumatic Drugs
Drug Therapy of Rheumatoid Arthritis
Rheumatoid ARHTRITIS Therapeutics 4th stage.
My Treatment Approach to Rheumatoid Arthritis
Clinical Updates in RA: New Developments and Insights From Washington
What’s new in my specialty- Rheumatoid Arthritis
Musculoskeletal Pharmacology
Epidemiology of rheumatoid arthritis
Disease Modifying Anti-rheumatic drugs
Low-dose glucocorticoid chronotherapy in rheumatoid arthritis (RA) include the night-time-release prednisone, a timing drug release formulation with administration.
Anti- Inflammatory, Antiarthritis, and Related Agent
Suggested therapeutic management according to subtypes and severity of rheumatic immune-related adverse events (irAE). *Add-on therapy with DMARDs (disease-modifying.
Presentation transcript:

Copyright © 2013, 2010 by Saunders, an imprint of Elsevier Inc. Chapter 73 Drug Therapy of Rheumatoid Arthritis

Copyright © 2013, 2010 by Saunders, an imprint of Elsevier Inc.2 Drugs for Rheumatoid Arthritis  Rheumatoid arthritis (RA)  Autoimmune inflammatory disorder  Treatment  Relieve symptoms  Maintain joint function  Minimize systemic involvement  Delay progression of disease

Copyright © 2013, 2010 by Saunders, an imprint of Elsevier Inc.3 Classes of Antiarthritic Drugs  NSAIDs  Nonsteroidal anti-inflammatory drugs  DMARDs  Disease-modifying antirheumatic drugs  Glucocorticoids  Adrenal corticosteroids

Copyright © 2013, 2010 by Saunders, an imprint of Elsevier Inc.4 Drug Selection for Rheumatoid Arthritis  Protocol  Start with NSAIDs  If symptoms persist, add DMARDs  Glucocorticoids may be added until DMARDs take effect

Copyright © 2013, 2010 by Saunders, an imprint of Elsevier Inc.5 DMARDs I: Major Nonbiologic DMARDs  Methotrexate  Sulfasalazine

Copyright © 2013, 2010 by Saunders, an imprint of Elsevier Inc.6 Methotrexate  Most rapid-acting DMARD  Therapeutic effect: 3 to 6 weeks  Adverse effects  Hepatic fibrosis  Bone marrow suppression  GI ulceration  Pneumonitis

Copyright © 2013, 2010 by Saunders, an imprint of Elsevier Inc.7 Sulfasalazine  Used to treat inflammatory bowel disease (IBD); now used for RA as well  Anti-inflammatory and immunomodulatory actions  Can slow progression of joint deterioration  GI side effects may be intolerable

Copyright © 2013, 2010 by Saunders, an imprint of Elsevier Inc.8 Other DMARDs I: Major Nonbiologic DMARDs  Leflunomid (Arava)  Hydroxychloroquine (Plaquenil)

Copyright © 2013, 2010 by Saunders, an imprint of Elsevier Inc.9 DMARDs II: Major Biologic DMARDs  Tumor necrosis factor inhibitors  Suppress immune function  Pose risk of serious infection  Work by neutralizing tumor necrosis factor (TNF) Etanercept (Enbrel) Etanercept (Enbrel) Infliximab (Remicade) Infliximab (Remicade) Adalimumab (Humira) Adalimumab (Humira)

Copyright © 2013, 2010 by Saunders, an imprint of Elsevier Inc.10 Etanercept  New DMARD  Inactivates TNF  Use  Moderate to severe RA  Adverse effects  Infection (may be serious)  Injection-site reactions  Tuberculosis  Heart failure  Cancer  Other adverse effects

Feedback: Privacy Policy Feedback
Do Not Sell My Personal Information
About project: SlidePlayer Terms of Service

© 2025 SlidePlayer.com. Inc. All rights reserved.