Structure and Function of Chemokines/Receptors

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Presentation transcript:

Structure and Function of Chemokines/Receptors Structure and Function of Chemokines/Receptors......... with Overall Goal to Contribute to Drug Development Multiple Sclerosis Rheumatoid Arthritis Neuroinflammation Pain Transplant Rejection Asthma Allergy Atherosclerosis Cancer Metastasis Diabetes HIV

Core Expertise: Biochemistry, Structural Biology, Cell Biology, Membrane Proteins Example: CXCR4:vMIP-II Qin et al, Accepted to Science. 2015

Core Expertise: Biochemistry, Structural Biology, Biophysics, Cell Biology, Membrane Proteins Cell-Based Assays; e.g. Ligand induced Receptor Internalization CCR2 with Small Molecule Cmpds Low off-rate and allosteric cmpds + allosteric cmpd decreasing off rate SPR for Interaction Affinities

Proposed Collaborations with SSPPS Faculty Ruben Abagyan: Docking and Structure analysis of chemokine receptors Dio Siegel: Small molecule compounds for chemokine receptor structures Bill Gewick: Natural products targeting chemokine receptors Jim McKerrow and Larissa Podust: membrane protein targets in tropical diseases Victor Nizet: Chemokines/receptors in microbial pathogenesis Debbie Spector: Chemokine/receptors and CMV Pieter Dorrestein: Chemokines/receptor in cell-cell communication by MS Geoffrey Chang: Nanobodies/antibodies against chemokine receptors Dong Wang: Stabilization of protein-protein complexes by disulfide locks for structure determination

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