PHARMANEXLifePak ® Anti-Aging LifePak ® Technical Training This material has been prepared by Pharmanex to be used in conjunction with general educational events and activities only. Alterations or modifications of this presentation without the express approval of Pharmanex are prohibited.

PHARMANEXLifePak ® What is LifePak ® ? A comprehensive supplementation program for a long and healthy life.* *This statement has not been evaluated the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

PHARMANEXLifePak ®  Ensures meeting all nutrient recommendations (RDAs)  Considers typical dietary intakes  Provides optimum nutrient levels for long-term health*  Includes “semi-essential” nutrients The LifePak ® Concept: Optimum Supplementation *This statement has not been evaluated the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

PHARMANEXLifePak ® LifePak ® Health Benefits Optimum supplementation for general well-being* 1. Addresses nutrient deficiencies* 2. Has cardiovascular benefits* 3. Provides complete bone nutrition 4. Promotes healthy immune function* 5. Maintains blood sugar levels already within the normal range* 6. Protects against the symptoms of aging* *These statements have not been evaluated the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

PHARMANEXLifePak ® Source: USDA CSFII 1. Nutrient Deficiencies

PHARMANEXLifePak ® 1. Nutrient Deficiencies

PHARMANEXLifePak ® Over 20 Antioxidants: protect blood lipids (LDL) from oxidation by free radicals* 2. Cardiovascular Benefits The Silent Benefits of LifePak ® : You don’t feel them at first, but you will appreciate them years later! *This statement has not been evaluated by the Food &Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

PHARMANEXLifePak ® Calcium & Magnesium: maintain normal blood pressure and heart function* B Vitamins: maintain normal blood homocysteine* Flavonoids: promote blood circulation* 2. Cardiovascular Benefits Over 20 Antioxidants: protect blood lipids (LDL) from oxidation by free radicals* *These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

PHARMANEXLifePak ® 3. Bone Nutrients  Calcium (500 mg): Major bone mineral; RDA: 1000 to 1300 mg/day; typical intake: 800 mg/day  Magnesium (250 mg): Major bone mineral; RDA: 280 to 320 mg/day  Vitamin D (400 IU): Regulates Ca and Mg bone metabolism; deficiencies in Northern countries  Vitamin K (40 mcg): Ca transport into bone  Silicon (3 mg): Bone calcification and collagen  Boron (3 mg): Regulates bone cell function  Soy Isoflavones (10 mg): Regulate Ca metabolism  Phosphorus (0 mg): Do not supplement with P! *These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

PHARMANEXLifePak ® * These statements have not been evaluated the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. 4. Immune Function LifePak supports normal immune function*  Vitamins C & E  Multi-Carotenoid Blend  Vitamin A, Vitamin B 6 & Zinc LifePak ® provides long-term immune system support;* Immune Formula promotes short-term immune response.*

PHARMANEXLifePak ® LifePak ® maintains blood sugar levels already within the normal range.* Chromium, 200 mcg:  essential for normal insulin function  most diets are low in chromium (<50 mcg/day) 5. Blood Sugar & Insulin Vitamin C, 500 mg Vitamin E, 300 IU Alpha-Lipoic Acid, 30 mg Magnesium, 250 mg Zinc, 15 mg *These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure of prevent any disease.

PHARMANEXLifePak ® LifePak ® Addresses the Root Cause of Aging: DNA Damage  DNA (DeoxyriboNucleic Acid) is your genetic blueprint  DNA enables healthy cell renewal into old age 6. Aging Symptoms

PHARMANEXLifePak ® Cell Old Cell Days to Months Cell Division New Cells Background Information Programmed Cell Death (Apoptosis) Old Cell

PHARMANEXLifePak ® Nucleus Cell DNA G T C A Mitochondria

PHARMANEXLifePak ® DNA is damaged by free radicals: A Antioxidants “catch” free radicals before they can hurt us

PHARMANEXLifePak ® Extent of DNA Damage 73,000 DNA damage events per cell every day! DNA repair enzymes fix most of the damage

PHARMANEXLifePak ® Mitochondria: “The Perpetrators of Aging” 2 to 5% of the oxygen used by mitochondria is diverted to produce free radicals!

PHARMANEXLifePak ® Mitochondria produce free radicals

PHARMANEXLifePak ® Body Cell Summary: How Do We Age? Weak Antioxidant Defense DNA Damage Free Radical Production DNA Damage Impaired Cellular Function and Cell Regeneration Impaired Energy Production Aging Symptoms Mitochondria Cell Nucleus

PHARMANEXLifePak ® What Causes DNA Damage?  Free radicals from environmental pollution (Ozone)  Radiation exposure:  sunlight (UV-light), X-rays, cosmic radiation (airline travel), radioactivity  Smoking:  10,000,000,000,000,000 free radicals/cigarette!  Free radicals from your mitochondria

PHARMANEXLifePak ® Reduce DNA Damage 1. Reduce your exposure to free radicals!  don’t smoke  avoid excessive sun exposure (use sunscreens)  avoid polluted areas 2. Improve your antioxidant defense!  eat more fruits and vegetables  take LifePak ®

PHARMANEXLifePak ® LifePak ® provides an arsenal of nutrients that fight DNA damage, protect DNA, and enhance DNA repair.* *This statement has not been evaluated the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

PHARMANEXLifePak ® LifePak ® & DNA Damage

PHARMANEXLifePak ®

Green Tea and Longevity

PHARMANEXLifePak ® Green Tea  Green Tea => Oolong Tea => Black Tea  Contains CATECHINS (flavonoids)  C, EC, ECG, EGC, EGCG  very potent antioxidants  green tea catechins reduce DNA damage

PHARMANEXLifePak ® Green Tea and Longevity Green Tea Consumption (Cups/Day) Prospective, 11-year cohort study of 8,552 subjects in Yoshimi, Japan, From: H. Fujiki et al., Ann. N.Y.Acad.Sci., 928:274, 2001; used with author’s permission.

PHARMANEXLifePak ®

Alpha-Lipoic Acid “The Universal Antioxidant”  augments the body’s entire antioxidant network, including glutathione and coenzyme Q 10 *  has ability to neutralize many different free radicals*  crosses blood-brain barrier (protects nervous system)*  directly and indirectly reduces DNA damage*  best mitochondrial antioxidant* New LifePak ® : 30 to 50 mg alpha-lipoic acid *These statements have not been evaluated the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

PHARMANEXLifePak ® LifePak ® addresses the root causes of aging symptoms at the molecular level: DNA damage in cells and mitochondria* 6. Aging Symptoms *This statement has not been evaluated the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

PHARMANEXLifePak ® LifePak ® Health Benefits Optimum supplementation for general well-being* 1. Addresses nutrient deficiencies* 2. Provides cardiovascular benefits* 3. Contains complete bone nutrition 4. Promotes healthy immune function* 5. Maintains blood sugar levels already within the normal range* 6. Protects against the symptoms of aging* *These statements have not been evaluated the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

PHARMANEXLifePak ® Always the Right Program! LifePak ® :  all adults, 18 years and up  men, 18 to 40 years

PHARMANEXLifePak ® Always the Right Program! LifePak Women ® :  pre-menopausal women, 18 to 45 years

PHARMANEXLifePak ® LifePak Women ® All of the benefits of regular LifePak ®, plus:  Extra bone nutrition  more calcium, magnesium, and soy isoflavones  More iron for blood formation and energy*  Added nutrients for female hormone balance*  Evening Primrose and Borage seed oils,  Phytoestrogens  Cranberry Concentrate  promotes healthy urinary tract*  same as in one glass of cranberry cocktail *These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure of prevent any disease.

PHARMANEXLifePak ® LifePak Prime ® :  post-menopausal women  men over 40 years Always the Right Program!

PHARMANEXLifePak ® LifePak Prime ® All of the benefits of regular LifePak ®, plus:  Extra bone nutrition  more Calcium and Magnesium  Extra Anti-Aging Nutrients and Antioxidants  more alpha-lipoic acid and grape seed extract (50 mg)  added Coenzyme Q 10 and L-Glutathione  Glucosamine for flexible, healthy joints*  BioGinkgo ® 27/7 for brain circulation/memory*  Extra Zinc and Vitamin B 12 for immune function* *These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure of prevent any disease.

PHARMANEXLifePak ® Always the Right Formula! LifePak PreNatal ® LifePak ® Teen Jungamals ® LifePak Trim ®

PHARMANEXLifePak ® LifePak ® Safety  All vitamin and mineral levels are below the NOAEL (No Observed Adverse Effect Level) established by the CRN (Council for Responsible Nutrition, 1998)  Phytonutrients are added at food levels that are documented safe  Clinical LifePak ® studies showed no adverse effects

PHARMANEXLifePak ® LifePak ® Directions One packet, twice daily with meals  meals enhance absorption (vitamins) and improve tolerance (minerals)  twice daily promotes steady nutrient delivery, e.g., plasma levels of vitamin B 6 7:30 a.m.6:30 p.m.

PHARMANEXLifePak ® Question: “On the following scale please rate how well you believe LifePak works.” (n=234, Dec. 2001) LifePak Market Research 91% of the participants feel LifePak works in the ‘well’ and ‘extremely well’ ranges! Mean = =Not at all and 5=Extremely well

PHARMANEXLifePak ® Question: “Do you believe LifePak makes a difference in the way you feel?” (n=234, Dec.2001) LifePak Market Research 95% of the participants believe LifePak makes a difference in how they feel.

PHARMANEXLifePak ® LifePak Market Research Top three reasons LifePak makes a difference in the way people feel:  Increased energy  Healthier immune system  Better sleeping habits

PHARMANEXLifePak ® Conclusion LifePak ® is unique, because it is a comprehensive wellness program that gives all the nutrients you need for a long, healthy and productive life.* *These statements have not been evaluated by the Food & Drug Administration. These products are not intended to diagnose, treat, cure of prevent any disease.

PHARMANEXLifePak ® Copyright 2002 by Pharmanex LLC The copyright owner grants permission to Pharmanex employees, distributors, and other representatives to use this presentation IN ITS ENTIRETY for educational purposes only. It cannot be changed or modified in any way without prior written permission of the copyright owner.