Reaxys ‘The new web based workflow solution for Chemical Scientists’ Dr. Denis Reidy, Product Sales Manager

Agenda What is Reaxys? What is the content and the primary source of information? Who is it for? What are the values for different types of users? Competitive analysis Customer feedback 2

 Chemistry, Engineering and Medical Specialities the top 3 main R&D areas in Turkey  Chemistry illustrates the most inter-disciplinary strengths  70% of the articles related to No. 1 distinctive competencies in Turkish universities are from the field of chemistry  5.85% article increase across all disciplines in Turkey in 2010, 6 th in growth globally Chemistry R&D in Turkey Turkey values chemistry and desires increased visibility

What is Reaxys?

 Elsevier’s premier workflow tool for research chemists & related science  An extensive repository of chemical properties and reaction data presented with chemistry as the organizing principle  A resource for accurate and validated experimental data. High quality answers you can use with confidence.  A simple interface, easy to work with. Analysis and planning tools offer new, and fast functions that help identify and plan the synthesis of molecules.  A web-based product that makes chemistry research more efficient, and helps to achieve better results. Simply access at What is Reaxys?

Chemistry ~200 years of organic, organometallic and inorganic chemistry Experimentally validated structural, chemical, and physical data from Journal articles and patents Based on the 3 CrossFire Databases. Intuitive Easy to use, appealing web-interface, available anytime and anywhere without limits and without installation needs Allowing chemists to query and filter by property data, design the optimum synthesis route, and view multi- step reactions. Created from scientist for scientist Workflow Solution Supporting scientists in life science and chemistry in industry and academia in their daily work Providing decision support in finding relevant and validated chemical information Helping to reduce time and efforts in building synthesis plans Journal of Catalysis Analytical Chemistry Tetrahedron J. Org. Chem. J. Med. Chem. J. Am. Chem. Soc. Heterocycles Applied Spectroscopy J. Of Mass Spectrometry Biomolecular Spectroscopy Biochemical Pharmacology Bioorganic and Med. Chemistry Chem. of Natural Compounds Experimental Physiology J. of Crystal and Mol. Structure J. of Magnetic Resonance etc..... What is Reaxys?

What do chemists want to know? 1.What is this? Is it novel? Patented? What are its physical characteristics (weight, melting point, etc?) 2. What does it do? Is it a reagent? Solvent? What is its bioactivity? Pharmacology? Is it toxic? 3.How can I make it? How can I change it? How can I make it better?

Where would you need Reaxys - a customer’s question to the world TO: SUBJECT: [CHMINF-L] Looking for Information My patron is looking for a prep of CAS RN which is 4-pyrmidinol, 2,5,6-triamino- 4- (hydrogen sulfate).

The ‘standard’ old method of finding answers – dig through the literature TO: SUBJECT: [CHMINF-L] Looking for Information One of our searchers at found these two references through. These may provide information relevant to query: Bisheterocyclic synthesis and antimicrobial studies on some biologically significant 2-[N-(3'- chloro-4'-substituted azetidinone-2)]amino-6-hydroxypurines. Sharma, Pratibha; Kumar, Ashok; Sharma, Shikha. School of Chemical Sciences, Devi Ahilya University, Indore, India. Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry (2004), 43B(2), Publisher: National Institute of Science Communication, CODEN: IJSBDB ISSN: Journal written in English. Synthesis of guanine. Chen, Xin; Wang, Ying. China Pharm. Univ., Nanjing, Peop. Rep. China. Zhongguo Yiyao Gongye Zazhi (1992), 23(1), CODEN: ZYGZEA Journal written in Chinese Original Message----- From: xxxxxx To: My patron is looking for a prep of CAS RN which is 4-pyrmidinol, 2,5,6-triamino- 4- (hydrogen sulfate). Does not answer the researchers’ question. Researcher needs to know how, not where or if. Two citations – no data

1H NMR 300 MHZ Reaxys extracts valuable chemical properties and reaction details from journals and patents...

......And gives you what no other database has..... > 29 million Reactions (how things are made) Properties for > 19 million Substances

Hundreds of searchable fields

Interoperability with Scopus and Science Direct for a full solution for researchers

Reaxys provides explicit answers What chemistry is known about a certain research topic/effect? Which compounds have a certain physicochemical property? Which compounds show certain biological effects? Does a compound exist and if so what is known about it? Is it toxic? What are its physical characteristics (melting point, solubility, etc?) Any biological effects known? How can I get a given compound? Can I make it and if so how? Can I buy it? Can I make something like it? Can I make it better? Melting Point Solubility Pharm.Effect

Who is Reaxys for?

Reaxys supports the discovery process in synthetic chemistry and related disciplines Medicinal chemists Synthesis chemists Process engineers Chemical engineers Information Specialists

How does Reaxys answer the researcher’s question? With one simple query, Reaxys gives them an exact answer with detailed experimental data and references for the full-text article if needed. "...advantage is that the reaction data is already extracted from the journal article citations, whereas SciFinder will provide you with a list of references which you then must order and read“ subject librarian from US

Unique tools that save researchers days of reading Create full synthesis plans with all experimental details Each step can come from a different publication Complex problems normally requiring weeks of research can be done in minutes “What you just showed would have taken me a week to do” Dr Andy Liepa, CSIRO Chief Research Scientist and namesake of Liepa phenanthrenes synthesis

Five good reasons to use Reaxys 1.The wealth of experimentally validated data which can be searched, filtered and ranked to find the most relevant answer to a specific question quickly. 2.Functionality beyond data searching: synthesis planner, results management, smart analysis tools for fast evaluation. 3.No user or usage limits: flat-rate for institution-wide access at any time. 4.The intuitive interface and online educational material help reduce your training efforts. 5.Interoperable: linking to SciVerse Scopus, full- texts at publishers and patent offices. Access to your own library settings via OpenURL resolver is possible. Professor Peter Johnson, University of Leeds

Competitive Analysis: Reaxys is built for chemists’ workflow Reaxys  Tools and features deliver actionable outcome  Reactions generated across articles and patents  Workflow driven, refineable searches, easy-to-use  Exporting capabilities: RD/SD files, Excel, pdf Other chemistry databases  Often just give links to articles that then must be read  Difficult to navigate across the various results and databases  User interfaces not intuitive, steep learning curves  Limited exporting

A comparison (done by a customer) Bibliographic Result (what the customer reported): Reaxys: 4 Patents SciFinder:6 Patents 2 of the 4 that Reaxys found did not come up in SciFinder The value of a Result is not equal to the Number of Patents in the Database, but to the quality of the indexing. However, the value of SciFinder is equal to the number of Patents found with a search. Conclusion: Always look behind the numbers Factual Result: Reaxys:20 Reactions (5 out of Patents, including an experimental procedure from 1988) SciFinder:No Reaction This is what we always need to ask for: which results did the search give, besides a bunch of Patents to read? Conclusion: After comparing to the SciFinder strength, check what does SF has against Reaxys’ strength!

How does Reaxys rate with top research? 10 of the Global Top of the Global Top of the Global Top Global Chemistry Rankings

“ I can get my work done 3 times faster since I have begun searching Reaxys. Life has certainly become easier. The interface really enables me to find the content I need and to get it out. I find that it’s more difficult to extract data from SciFinder. ” “ It’s a very straightforward way to obtain and sift through a huge amount of information from over the last 150 years. ” “ I really like the simplicity of the user interface. I don’t have to read manuals to get answers fast. ” “ The flat rate access is important for every moderate to large institution. Now we have access for a sufficient number of simultaneous users. ” Peter Johnson, PhD, University of Leeds Research Professor, School of Chemistry Reaxys Value Story

But don‘t just listen to us, listen to our customers “ It is obvious that Reaxys has been programmed with the needs and expectations of chemists in mind” Prof. Ulrich Jordis, Vienna University of Technology, Austria "After almost one year of searching and using Reaxys, my users and I just love it." Norah Xiao, Science Librarian, University of Southern California "The patent information is great." Professor Anthony Barrett, Imperial College London “Reaxys is a joy to use… It’s beautiful.” US Librarian “Reaxys thinks and works like chemists do. So it’s easy for most chemists to find the information they need.” Tommi Meulemanns, Mercachem “Whenever we hit stumbling blocks, Reaxys helps drive the critical decisions.” Group Leader, Acoris "A chemist without access to Reaxys is like a computer without a monitor. It's able to work, but is blind" Vladimir Maslenko, Senior Researcher, Organic Chemistry: Mendeleyev University of Chemical Technology

Any Questions about Reaxys ……... And if you have any questions about Reaxys or search strategies, please contact us: 26

Maximising the Chemistry Research Workflow Thank you Dr. Denis Reidy