Kuehne + Nagel – AMS Pharma Gateway 20-4-2017 Kuehne + Nagel – AMS Pharma Gateway Amsterdam Airport Schiphol – CoolZone AMS CoolZone Sales Presentation

KN PharmaChain: AMS Pharma Gateway Pharma Gateway Specifics GxP compliant trained staff KN PharmaChain SOP / WI’s outlining all handling procedures Dedicated Pharma team “CoolZone” temperature controlled storage meeting GxP requirements & having two defined temperature zones (+2°C to +8°C & +15°C to +25°C) Replace picture AMS CoolZone

KN PharmaChain: AMS CoolZone Location Located at Amsterdam Airport Schiphol Airside facility (direct platform access – 1st Line facility) Close to near by sea ports of Rotterdam, Amsterdam, Moerdijk and Antwerp Well connected to the main European highway network (E19, E35, E22, E231) Excellent hinterland connections in and out of European markets Schiphol Airport

KN PharmaChain: AMS CoolZone Airside Facility

KN PharmaChain: AMS CoolZone Specifications 24/7/365 operation GxP compliant facility & processes Acts as cross-dock and emergency storage facility Two defined temperature controlled storage areas +2ºC to +8ºC (approx 32 warehouse pallet positions) +15ºC to +25ºC (approx 72 warehouse pallet positions) Temperature controlled acceptance area +15ºC to +25ºC temperature controlled portal for temporary storage and cargo acceptances purposes Dedicated cargo loading area for active temperature controlled ULD’s Definition of CoolZone: GxP Compliant Two Designated Temperature Zones +2ºC to +8ºC & +15ºC to +25ºC Where required: PCM and Gel pack Conditioning Areas Freezer Facilities

KN PharmaChain: AMS CoolZone Facility Layout +15ºC to +25ºC Restricted access Pre-chamber ‘Buffer Zone’ Entrance +15ºC to +25ºC cool room +2ºC to +8ºC +2ºC to +8ºC cool room Machine room Backup generator ULD re-charging stations Direct ramp access

KN PharmaChain: Wireless Monitoring - AMS CoolZone Connecting Your Sensors For Seamless Data Transmission to KN Login 1 wireless Gateway communication unit located in AMS CoolZone Sensors installed in temperature controlled areas (see pictures) +2ºC to +8ºC +15ºC to +25ºC Temperature mapped and monitored facility Transmitter supports up to 600 active wireless sensors per location Resident sensors can be added to extend the range of the AMS Gateway Transmits all data to KN Login and will not interfere with existing IT wireless infrastructures Active wireless sensors - activates with a simple push of the button Shipment sensor shown in picture CareTeam proactively monitors the wireless sensor data, taking action when required

KN PharmaChain: Value Added Services at AMS CoolZone Additional Options to Fully Customize Your Shipment Needs Shipment Preparation Repackaging Relabeling Packaging solutions Pre-conditioning Consolidation / deconsolidation Cross-docking Recall possibilities / procedures Customs Services Import / Export customs clearance Fiscal Representation VAT Deferment

KN PharmaChain: Value Added Services at AMS CoolZone Additional Options to Fully Customize Your Shipment Needs Replenishment Replenishment of dry ice and batteries for active temperature controlled ULD’s Phase Change Material and Gel packs Gel packs and Phase Change Materials pre-cooling and exchange Re-charging Recharging stations for active temperature controlled ULD’s All heating and cooling types

KN PharmaChain: AMS CoolZone KN PharmaChain Road KN PharmaChain Road is a specialized and dedicated road network product for the Pharmaceutical and Healthcare industry AMS CoolZone connected to KN PharmaChain road network Temperature mapped trucks with wireless tracking and tracing Wireless tracking and tracing (transmitter - mobile unit) is located on the truck´s dashboard for GPS & GPRS connection (temperature monitoring) Dedicated conditioned trucks for pre- and on-carriage Owned equipment includes Mono/Bi-Thermo and double stack trucks Offering daily departures across Europe and beyond from AMS CoolZone Express deliveries and pickups Additional services include: re-icing / gel-pack replenishment Truck temperature control process Kuehne + Nagel also uses a selected number of highly qualified subcontractors for temperature controlled trucking services

KN PharmaChain: AMS CoolZone Your Dedicated NL Pharma Team AMS CoolZone staff (performing VAL’s, shipment preparation) Fully trained & GxP compliant Operational Service Desk Pharma desk - Netherlands CareTeam (Global - 24/7) QSHE Manager Airfreight Facility/QSHE Manager In-line with WHO regulations/GDP Policy

KN PharmaChain: AMS CoolZone Security features / other Security cameras (CCTV) 24/7/365 controlled access high security Restricted access Dedicated staff (key card access) Special panel finishing (walls) Temperature controlled areas built with special panel finishing for hygienic solution Backup generator Refrigeration and heating system – redundant solution and back-up generator Pre Chamber Provides a temperature buffer between the cargo handling and storage area

KN PharmaChain: AMS CoolZone Environmentally friendly features 20-4-2017 KN PharmaChain: AMS CoolZone Environmentally friendly features “Kuehne + Nagel is committed to offering environmentally sound, sustainable and innovative supply chain solutions that continually reduce our impact on the environment” Green AMS CoolZone features include: Energy efficient lighting (automatic sensors) CO² monitored facility PVC Strip curtains – saves energy, keep rooms better insulated 100% recyclable panels (CFC free) The refrigerant used has an ODP value of zero Hermetic compressors – energy efficient, noise reduction AMS CoolZone Sales Presentation

Why Kuehne + Nagel – AMS CoolZone? Your Dedicated Partner Contract Manufacturing AMS CoolZone located in heart of European consumer belt and excellent transport connections Focus on Pharmaceutical & Healthcare solutions (dedicated facility) Integrated Logistics Service Provider (Sea, Air, Road and Rail, Contract Logistics) Secured solutions for Pharmaceutical & Healthcare goods Strong IT Management and temperature monitoring solutions Dedicated Key Account Management / Pharmaceutical & Healthcare Team Global Coverage & Network (1000 offices worldwide) In-house Customs department / Insurance (Nacora) Dedicated range of Pharmaceutical & Healthcare value added services Local NL QSHE is well connected and aligned to our Global QSHE (SGI) team

Thank you for your attention 20-4-2017 Thank you for your attention AMS CoolZone Sales Presentation