The Dr. John T. Macdonald Foundation Biomedical Nanotechnology Institute at the University of Miami (BioNIUM) Richard J. Cote, M.D., FRCPath, FCAP, Director Ram H. Datar, M.Phil, Ph.D., Co-Director Sylvia Daunert, Ph.D., Pharm.D., Associate Director

Mission: Early detection and diagnosis Targeted delivery and treatment monitoring Restoration of tissue and organ function Vision: Multidisciplinary collaboration and technology development Integrate nanotechnology and medicine to: – Develop and deploy devices and systems – Interact with living tissue – Provide size and physical property advantages Educating the next generation of physicians, scientists and engineers BioNIUM Mission and Vision

Cancer: Early detection of circulating tumor cells Insensitive and expensive detection of serum biomarkers Adverse drug effect on non-targeted cells and organs Endocrine and Cardiac Diseases: Inability to continuously monitor glucose or cardiac enzymes Restore lost function Neuromuscular Diseases : Once disease is treated, full restoration remains distant goal Overcoming Significant Barriers to Early Effective Treatment Interdisciplinary Collaboration: Physicians, Biomedical Researchers, Physicists, Chemists, Engineers, Material Scientists  Link researchers from disparate disciplines to expand scientific knowledge  Opportunities to exchange and expand novel ideas

Richard J. Cote, M.D., professor and Joseph R. Coulter Jr. Chair of Pathology Ram Datar, M.Phil., Ph.D., associate professor of pathology and biochemistry and molecular biology Sylvia Daunert, Ph.D., Pharm.D., professor and the Lucille P. Markey Chair of Biochemistry and Molecular Biology James M. Tien, Ph.D., DEng, NAE, dean School of Engineering Richard Awdeh, M.D., assistant professor of clinical ophthalmology, Bascom Palmer Eye Institute Leonidas Bachas, Ph.D., dean College of Arts and Sciences Pirouz Daftarian, Ph.D., research assistant professor of microbiology and immunology Sapna Deo, Ph.D., associate professor of biochemistry and molecular biology Jeffrey Goldberg, M.D., Ph.D., associate professor of ophthalmology Angel Kaifer, Ph.D., professor of chemistry Sung Jin Kim, Ph.D., assistant professor of electrical and computer engineering Vincent Moy, Ph.D., associate professor of physiology and biophysics Francisco Raymo, Ph.D., professor of chemistry Paolo Serafini, Ph.D., research assistant professor of microbiology and immunology Cherie Stabler, Ph.D., assistant professor of biomedical engineering and director of the tissue engineering program at the Diabetes Research Institute Onur Tigli, Ph.D., assistant professor of electrical and computer engineering BioNIUM Members: Multidisciplinary Leaders Converge

Dr. John T. Macdonald Foundation Propelling BioNIUM Forward  A leadership contribution of $7.5 million over five years will provide crucial support to: Recruit leading experts Equip and operate a state-of-the-art microfabrication and nanofabrication core facility Launch ‘high risk-high yield’ pilot research projects Educate the next generation of physicians, biomedical scientists and engineers Support scientific leadership and oversight, and create scientific advisory boards  University of Miami has committed additional funds of $4.8 million  Provost - $2.8 Million  Dean of the Miller School - $1 Million  Dean of the College of Engineering - $1 Million  Return on Investment: This grant will stimulate creation of over 85 new highly skilled jobs in Miami-Dade County and result in over $100M in research funding.

Progress with Nanofab Clean Room Nanofabrication facility clean room space identified in Life Science & Technology Park, 1 st floor A 1200 Sq. Ft. Space within the Tissue & Bone Bank Equipment orders will begin shortly Support Staff recruitment planned for Fall of 2012 Facility Business Plan ready

Opportunities  The combination of recent and ongoing recruitments presents an ideal moment for the establishment of the Dr. John T. Macdonald Foundation BioNIUM.  The resources provided by the Dr. John T. Macdonald Foundation gift establish major programmatic support, enhance recruitment efforts and allow for the build out of critical infrastructure (nano/micro fabrication clean room facility).  With a critical mass of human and technological resources, the BioNIUM will facilitate interdisciplinary collaborations that will accelerate the pace of discovery.

Organizational Overview Led by a Director: Responsible for articulating and representing the vision of the Institute, its overall leadership and management. The Director will report to and receive annual reviews from the Senior Vice President for Medical Affairs and Dean of the Miller School. Executive Committee: Advise the Director on issues related to Institute operations. Advisory Committee: Assess the scientific progress of the Institute and assist the Director in long term planning. Advisory Board: Representation from UM and the Dr. JT Macdonald Foundation. Provide insight and recommendations Four Scientific Programs (led by Program Directors) and two Shared Resources (led by Resource Directors).

BioNIUM Programs & BioNIUM Resources Programs – Sensing & Molecular Diagnostics – Molecular Assemblies and Characterization of Nanostructures – Functional Restoration and Biomaterials – Targeting, Delivery and Imaging Using Nanocarriers Resources – Nanofabrication Facility – Interdisciplinary Educational Resource

Space Research activities of the Dr. John T. Macdonald Foundation BioNIUM require a well-equipped fabrication facility, and office and administrative space. Initially the main offices of the Institute will reside in the Biomedical Research Building on the Miller Campus The state-of-the-art nanofabrication facility will be located at the Life Science and Technology Park. Through its affiliate membership laboratories, the Institute will have space on the Coral Gables and Miller School campuses.

BioNIUM Organizational Chart Executive Committee Resource Director, Nanofabrication Facility & Resource Director, Educational Resources Associate Director Co-Director Advisory Committee Program Director, Sensing & Molecular Diagnostics Program Director, Molecular Assemblies & Characterization of Nanostructures Program Director, Functional Restoration Program Director, Biomaterials, & Targeting, Delivery and Imaging Using Nanocarriers Senior Vice President for Medical Affairs & Dean Director, Dr. John T. Macdonald Foundation BioNIUM Advisory Board

BioNano Medicine: The Final Frontier– Science Fiction? Now a reality!