MS Lesion Visualization Assisted Segmentation Daniel Biediger COSC 6397 – Scientific Visualization.

Slides:

Advertisements

Similar presentations

MOTOR NEURON DISEASE The motor neuron diseases (or motor neuron diseases) (MND) are a group of neurological disorders that selectively affect motor neurons.

Advertisements

VBM Voxel-based morphometry

Multiple Sclerosis By Rachel Utnage and Anne Creech 1 st Period-Anatomy and Physiology (Honors) April 30 th, 2013.

Multiple Sclerosis (MS) LaTasha Wilson Nate Jr.. Pathophysiology of MS In MS, the body’s own defense system attacks myelin, the fatty substance that surrounds.

Leigh Vaughan, MD June 5, 2012 MUSC. Outline CT Advantages, disadvantages Modality basics Appropriate uses With or without contrast MRI Advantages, disadvantages.

Richard Simmons, M.D. Child Neurologist Schenectady Neurological Consultants.

Fund BioImag : MRI contrast mechanisms 1.What is the mechanism of T 2 * weighted MRI ? BOLD fMRI 2.How are spin echoes generated ? 3.What are.

By: Tracy Ssali Medical Biophysics 3970z April 4 th 2012 Supervisors: Keith St. Lawrence, PhD Udunna Anazodo, PhD candidate.

Hind ALNajashi,MD R3 neurology resident Neurology Teacher Assistent KAU.

ISMRM 2010 Quantitative Imaging and MS. N. D. Gai and J. A. Butman, NIH T1 Error Analysis for Double Angle Technique and Comparison to Inversion Recovery.

Multimodal Visualization for neurosurgical planning CMPS 261 June 8 th 2010 Uliana Popov.

Introduction to MRI Head Imaging

Automatic Image Segmentation of Lesions in Multispectral Brain

Multiple Sclerosis Presented By: Dallas Cole And Andy Coffey.

Multiple Sclerosis (MS) By: Morgan Farr Biology 1010.

Adam Percey. What is it?  MS is a disease of the central nervous system.  What happens is the myelin sheaths around the axon of a nerve fade away. These.

Multiple Sclerosis Brett Catlin Period Seven September 3 rd, 2003.

Idoia Corcuera-Solano, Gerard Reddy, Bradley Delman, Reade De Leacy, Dan Rettmann, Lawrence N Tanenbaum EP

Multiple Sclerosis Alan Chen 4/1/14. General Information Other names: disseminated sclerosis or encephalomyelitis disseminata Inflammatory disease that.

RT 4912 Review (A) Rex T. Christensen MHA RT (R) (MR) (CT) (ARRT) CIIP.

Sagittal FLAIR images - Stable nonenhancing hyperintensities within the pericallosal white matter and bilateral centrum semiovale, consistent with known.

DIFFUSION & PERFUSION MRI IMAGING Dr. Mohamed El Safwany, MD.

Possible Cures/ Treatments Crohn’s Disease- Intestinal disease that causes pain and can sometimes lead to death. -Symptoms of interest: damaged intestinal.

Human Physiology Multiple Scolerosis. Multiple sclerosis is an autoimmune disease that affects the brain and spinal cord (central nervous system) autoimmune.

MULTIPLE SCLEROSIS Ana Costas Barreiro.

The Nervous and Immune Systems

NA-MIC National Alliance for Medical Image Computing ABC: Atlas-Based Classification Marcel Prastawa and Guido Gerig Scientific Computing.

Beyond FLAIR: Expanding the Role of Inversion Recovery in MR Imaging of the Brain Ali Batouli 1 Michael Spearman 1 Michael Goldberg 1 Emmanuel Kanal 2.

Sacha Ingram & Masai Kofa.  Multiple Sclerosis is an autoimmune disease affecting the central nervous system, causing permanent damage to the myelin.

Neuroimaging in Neuropsychiatry

Laboratory for Product and Process Design Computer Assisted Design of Transport Processes in the Human Brain Laboratory for Product and Process Design,

Multiple Sclerosis & H1N1 Flu Virus Crosson Nipper, Lauren Kline, Lee Boone.

Segmentation with Corrected MPRAGE Scans and FSL Jason Su.

Multiple Sclerosis By Kelsey Dussault May 23, 2011.

Multiple Sclerosis (MS) a serious, chronic and debilitating disease What is MS? A disease of the brain and spinal cord.

Multiple Sclerosis. What is MS? This is a chronic and often disabling disease in which the body’s immune system (t-cells) attacks the central nervous.

CATEGORY: IMMUNE DYSFUNCTION Multiple Sclerosis Lindsay Nicholson, University of Bristol, UK [ Multiple sclerosis (MS) is.

MRI B 陳名揚.

Presented by: Anum Masood PhD Scholar

Alivia, Clifford, and Crystal. Multiple Sclerosis is an unpredictable disease of the central nervous system, multiple sclerosis (MS) can range from relatively.

Multiple Sclerosis (MS)

Multiple Sclerosis [

Random Forests For Multiple Sclerosis Lesion Segmentation

Nat. Rev. Neurol. doi: /nrneurol

MRI findings in MS. A. Axial first-echo image from T2-weighted sequence demonstrates multiple bright signal abnormalities in white matter, typical for.

Ali Batouli1 Dennis Monks1 Sobia Mirza1 Michael Goldberg1

Silent Brain Infarcts by Yi-Cheng Zhu, Carole Dufouil, Christophe Tzourio, and Hugues Chabriat Stroke Volume 42(4): March 28, 2011 Copyright ©

MRI and possible differentiating features with nonconventional MRI

Figure 1 Perivenous distribution of multiple sclerosis lesions

Figure 2. MRI features of patients with MS who had antibodies to myelin oligodendrocyte glycoprotein MRI features of patients with MS who had antibodies.

Nat. Rev. Neurol. doi: /nrneurol

Nat. Rev. Neurol. doi: /nrneurol

Stephen L. Hauser, Jorge R. Oksenberg Neuron

Cerebrospinal fluid.

Figure 4 Neuromyelitis optica spectrum disorder brain lesions

Multiple sclerosis and cerebral endothelial dysfunction: Mechanisms

Figure 2 Examples of lesions with and without central veins

Figure 2 7T MRI can differentiate between early PML and MS lesions Two different patterns of brain lesions were observed using 7T MRI: ring-enhancing lesions.

In 507 follow-up images, only 1

Anatomical Measures John Ashburner

Figure 2 Example of venous narrowing

Nat. Rev. Neurol. doi: /nrneurol

Figure 1 Detailed overview of treatment course and paraclinical findings Maximum intensity projection maps of supratentorial inversion recovery images.

Segmentation Algorithm

Figure Rapid progression of lesions after natalizumab treatment(A) MRI from February Rapid progression of lesions after natalizumab treatment(A)

Disease of the Central Nervous System By Eric Nauman

Images from the case of an 8-year-old female patient with complex I mitochondrial disease, which was diagnosed when the patient was older than 3 years.

Axial magnetic resonance imaging (MRI) of a 30 year old man with relapsing remitting multiple sclerosis (MS) showing multiple periventricular lesions:

Impact of approaches for clinical and radiological monitoring on predicting of short-term and long-term disability outcomes in multiple sclerosis Brian.

Atrophied Brain T2 Lesion Volume at MRI Is Associated with Disability Progression and Conversion to Secondary Progressive Multiple Sclerosis The rate.

Presentation transcript:

MS Lesion Visualization Assisted Segmentation Daniel Biediger COSC 6397 – Scientific Visualization

Multiple Sclerosis Autoimmune disease of the central nervous system Affects 2.5 million people globally, ~100 per 100,000 Damage to the insulating myelin sheaths around brain cells Appears as a range of cognitive and physical disability Progresses at different rates with remission and relapse 2 Myelin: ~40% water, ~40-50% lipids

Multiple Sclerosis Identified in-vivo with MRI images Normally 3 tissues: GM, WM, CSF (SG, SB, LCR) Lesion appear hyper- or hypo-intense (bright or dark) – Reflects a difference in relaxation times for lipids/water – Detected as an outlier to the normal WM – FLAIR MRI (Fluid Attenuated Inversion Recovery) best 3

MS Detection Challenges WM Lesion detection is a challenge – Overlap in intensity between tissue classes – 3D brain structure (sulcus, ventricles, multiple tissues) – Partial Volume Effects (PVE) – Artifacts from fluid/patient motion, tumors, etc – Random noise, bias field, sun spots, etc Requires an expert to identify lesions – Tissue identification (T1-weighted MRI) – Lesion detection (FLAIR MRI) – Time consuming, difficult (multi-modality), and subjective 4

MS Lesion Appearance in Flair 5 This? or Is this?

Result Comparison 6 Under Segmentation Correct Segmentation Over Segmentation DICE = 0.65 FLAIR MRIBase MethodExpertMe Results

Project Timeline 7

Questions 8 ?