Cancers of the Reproductive System Review Session November 19, 2012

Ashkan Afshin, MD, MPH ScD Candidate, Department of Epidemiology ScD Candidate, Department of Global Health & Population Harvard School of Public Health Room 913 Kresge Building, Room Huntington Avenue Boston, Massachusetts Phone: (949)

Review Sessions Format: Q & A (20 min) Discussing the questions received by (10 min)

Questions Please send your questions or suggestions to:  Text Message: (949) 

Midterm Exam

Stages of Tumor Development Weinberg RA. How cancer arises. Sci Am Sep;275(3): A B C E D

Stages of Tumor Development Weinberg RA. How cancer arises. Sci Am Sep;275(3):62-70.

Genetic Abnormalities in Cancer Cells

A.Oncogenes HER2 → Breast Cancer B.Tumor Suppressor: BRCA→ Breast Cancer

New cases of cancer in the US American Cancer Society. Cancer Facts & Figures Atlanta: American Cancer Society.

New cases of cancer in the US American Cancer Society. Cancer Facts & Figures Atlanta: American Cancer Society.

New cases of cancer in the US American Cancer Society. Cancer Facts & Figures Atlanta: American Cancer Society.

True or False? Testicular cancer is the most common form of cancer in men Positive family history of the testicular cancer increases the risk of the cancer Testicular cancers is more common in African American males. Carcinoma in situ can sometimes progress to invasive cancer Obese men show highest risk of testicular cancer

True or False? Testicular cancer is the most common form of cancer in men Positive family history of the testicular cancer increases the risk of the cancer Testicular cancers is more common in African American males. Carcinoma in situ can sometimes progress to invasive cancer Obese men show highest risk of testicular cancer

Race & Prostate Cancer World J Urol (2012) 30:195–200 Mortality Incidence

Race & Prostate Cancer World J Urol (2012) 30:195–200 Mortality Incidence

Diet & Prostate Cancer Risk Dietary FactorDirection of Effect Calcium Processed Meat Intake Fish Intake Vitamin D Tomatoes Giovannucci et al. Int. J. Cancer: 121, 1571–1578 (2007) Wilson et al. J Natl Cancer Inst. 2011;103(11): Chan et al. J Clin Oncol 23:

Diet & Prostate Cancer Risk Dietary FactorDirection of Effect Calcium  (fatal & adv disease) Processed Meat Intake  Fish intake  (fatal disease) Vitamin D  Tomatoes  Giovannucci et al. Int. J. Cancer: 121, 1571–1578 (2007) Wilson et al. J Natl Cancer Inst. 2011;103(11): Chan et al. J Clin Oncol 23:

Other Risk Factors for Prostate Cancer Risk FactorDirection of effect Height BMI

Other Risk Factors for Prostate Cancer Risk FactorDirection of Effect Height  (fatal disease) BMI  (adv/fatal disease)

Breast Cancer Risk Factors True or False? –Nulliparity –Early menarche –Early menopause –Postmenopausal hormone use –Older forms of birth control pills –Premenopausal obesity –Alcohol use

Breast Cancer Risk Factors True or False?  Nulliparity  Early menarche Early menopause  Postmenopausal hormone use  Older forms of birth control pills Premenopausal obesity  Alcohol use

Race/Ethnicity and Breast Cancer American Cancer Society. Breast Cancer Facts & Figures Atlanta: American Cancer Society.

Race/Ethnicity and Breast Cancer

American Cancer Society. Global Cancer Facts & Figures 2nd Edition. Atlanta: American Cancer Society; 2011.

Endometrial Cancer Risk Factors True or False: –Nulliparity, –Early menarche –Late Menopause –Obesity –Prior breast cancer treatment with tamoxifen –Polycystic ovarian syndrome (PCOS)

Endometrial Cancer Risk Factors True or False:  Nulliparity,  Early menarche  Late Menopause  Obesity  Prior breast cancer treatment with tamoxifen  Polycystic ovarian syndrome (PCOS)

Obesity Obesity is not a risk factor for: –Breast Cancer –Ovarian Cancer –Testicular Cancer –Prostate Cancer

Obesity Obesity is not a risk factor for: –Breast Cancer –Ovarian Cancer –Testicular Cancer –Prostate Cancer