Company presentation to Max Zeller Söhne AG January 2013 Ebsa pharma – your turnkey solution to the Chinese market Your participation in a Potential and Ever-Growing Medical & Pharmaceutical Market in China 1

Contents Services, medical and sales network Key figures of Chinese healthcare sector Features of pharmaceutical market in China Successful case of market introduction and sales 2

Services to European Pharmaceutical Lab Drug and Medical device registration with SFDA  Planning  Dossier preparation  Translation(s)  Clinical trial(s)  IDL registration – Import drug license (Class III, IIa, IIb medical device license) Drug and medical device marketing and distribution in China  Product introduction  Distribution  Terminal sales Services, medical and sales network 3

Organizational Chart Services, medical and sales network 4 4

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Ebsa pharma’s success is driven by 138 sales representatives and 5 marketing specialists. Our business geographical market area stretches over 14 provinces of which 8 are the most important in relation to current and expected future significant developments. Ebsa pharma ’s presence in key and sub-prime markets Beijing Guangdong (Dongguan, Guangzhou, Shenzhen) Henan (Luoyang, Zhengzhou) Hunan Jiangsu (Nanjing, Suzhou) Shandong (Jinan, Qingdao, Yantai) Shanghai Zhejiang (Hangzhou, Ningbo) Fujian (Fuzhou, Xiamen) Guangxi (Guiloin, Nanning, Liuzhou) Hubei Shanxi Sichuan Tianjin Heilongjiang Jilin Inner Mongolia Xinjiang Ningxia Shanxi Beijing Hebei Liaoning Gansu Shandong g Jiangsu Shanghai Zhejiang Fujian Yunnan Guizhou Jiangxi Anhui Henan Hubei Hainan Tibet Qinghai Taiwan Shanxi Sichuan Guangxi Guangdong Tianjin Chongqing Hunan Services, medical and sales network 7

Total health expenditure in China witnessed steady growth in the past few years (US$ 1 bn) CAGR=8% CAGR=11% CAGR=16% Source: According to official estimates, figures from China Statistical Yearbook, Espicom Business Intelligence and other institutions are more upbeat; as a whole, Chinese market presented strong growth in the past few years and based on good macroeconomic situation, improving personal ability to pay and enhancing individual’s attention on health, the growth will continue. Key figures of Chinese healthcare sector 8

Estimated by IMS, the pharmaceutical industry will grow significantly over the next 10 years, leading China into the second largest global pharmaceutical market behind USA. Pharmaceutical market in China will amount to 800 bn Yuan in 2013; it will amount to 2-3 trillion Yuan in 2020 to rank second in the world. Key driving factors:  Continuous economic growth and awareness of population’s health consciousness;  Added investment in health care reform favours the growth potential;  Stake of aging population increases. Source: IMS Health China’s domestic growth and global market size between Increase by 17% between and by 15.5% between USA Japan Germany France Italy UK Spain Canada Mexico China Japan USA Japan Germany France UK Italy China Spain Canada Turkey Key figures of Chinese healthcare sector 9

At present, hospitals take the lead in medical sales while retail pharmacies tend to increase their market share in future. However, imported and high priced drugs will continue to be mainly distributed in large-scale hospitals. Source: URC market survey Share of retail channel Share of hospital channel Changes in market shares of pharmaceutical sales in terminal market 45% 55% (Forecast) The percentage of drug consumption in medical institutions will decline as a result of various factors: The policies about the separation of prescribing and dispensing have been gradually carried out. The phenomenon of “patients buy medicine in pharmacy with prescription”, namely, policies about separated management of prescription and OTC drug, will realize the separation of drugs in hospital and pharmacy. The emerging of medical care designated pharmacy solves the worries of consumers to buy medicine in pharmacy. Pharmacy is allowed to diversify operations, so the investment in pharmacies increase to a certain extent. After 2015 Features of pharmaceutical market in China 10

Hospitals are the largest terminal clients of medical consumption and remain constant in numbers for the past few years. In addition, hospitals of upper class, witnessed small differences in numbers. Source: Data from Ministry of Health; Roland Berger analysis Changes on number of major medical institutions (10,000]Changes on number of hospitals of different classes (10,000) (During ) (During ) Clinic Health centre Hospital 其他 一级 二级 三级 ,420 8, Grade I Others Grade II Grade III Features of pharmaceutical market in China 11

It is seen from pharmaceutical consumption that the Grade III hospital exceeds the Grade II hospital by four times. However, the hospital quantity of the former is about one fifth of the later, therefore they are similar in pharmaceutical consumption. Annual pharmaceutical consumption of a hospital in various grades [ten thousand Yuan] Annual total pharmaceutical consumption of hospital in all grades [hundred million Yuan] Source: Data from Ministry of Health Grade IIIGrade IIInferior to grade IIGrade IIIGrade IIInferior to grade II Features of pharmaceutical market in China 12

Medical markets in China are mainly concentrated in coastal and developed cities. Source: The data is from commercial delivery condition of a large-scale multinational company. It is reflected hereby that hospitals are unreasonable in sales status. However, it can be judged that it is reasonable to have medical market especially the high-end medical market in developed cities and coastal areas. 11% 9% 30% 9% 15% 14% 13% Beijing Shanghai Guangzhou Hangzhou Nanjing Qingdao, Jinan Others Features of pharmaceutical market in China 13

It takes more than 5 years in Chinese market for a product to become matured from its launch. Market introduction period Swift growth period Market mature period 1-2 Years About 4 years 5-10 years Duration Market investment Market share Great market investment force Channel developing Medicare public relation Take share of opponents Increase market share Maintain market share Terminal excitation Channel gathering Deep distribution Pay attention to maintenance of customer loyalty index Consider introduction of new drugs 95’98’00’04’94’ million 1.5 hundred million CAGR138 % CAGR58 % CAGR29 % Schematic diagram: life cycle curve of pharmaceuticals Example: compound danshen dripping pills reaches to mature stage by 9 years. >8.2 hundred million Example Features of pharmaceutical market in China 14

Indication: peripheral nerve injury caused by poisoning of normal hexane Product medicament form and specification: 2000 units, powder-injection Product price: 168 Yuan/piece Product features ：  New compound, national category I new drug, biological agent  Indication is narrow, therefore it is impossible to form sale scale in indication popularization  Self-paying drug and not entering into NDRL  The product is less in curative effect material and low in doctor cognitive degree  There is only one enterprise manufacturing like products - Wuhan Hitecin Pharmaceutical Co., Ltd. with all-round management mode adopted. Product positioning:  The only drug in promoting orientated growth of injured neurocyte Sale mode:  Control terminal specialization popularization mode Successful case: Nerve growth factor of rat (NGF – brand 恩经复） ---- CNS Successful case of market introduction and sales 15

Product Research:  It is reported in literature that the product can promote orientated growth of neurocyte in the laboratory  The product is large in molecular weight. Although there is laboratory report for the product in penetrating blood-brain barrier. However, we found out through deep interviewing with doctors that most of them think that the product is difficult in penetrating blood-brain barrier.  It is the initial launching product, therefore there is less clinical data in promoting the product  There is only one like product with central nerve restoration of nerve internal medicine as main function Product positioning and objective market:  The only drug in promoting orientated growth of injured neurocyte  Main objective hospitals: Grade A class three large-scale hospital  Main departments for product: Paediatrics Orthopaedics Rehabilitation Department  Main diseases cured by the product Peripheral nerve injury (including peripheral nerve injury caused by trauma and peripheral nerve injury intercurrent with other disease) Newborn infant brain paralysis (newborn infant blood-brain barrier is not mature and can be penetrated by macromolecular substance) Product research and product positioning objective market: marketing starting point is to learn product Successful case of market introduction and sales 16

Product conception spread plan and execution:  Establish market budget and decomposition  Seek and confirm opinion leader from product spread industry Seek and confirm nationwide expert lecturers and communicate with them Seek and confirm regional expert lecturers and communicate with them  Confirm product conception spread items and fabricate related lecture material Preparation of slide Preparation of advertisement leaf  Establish market produce conception spread plan and implement the plan Nationwide conference plan: professional meeting plan in sponsoring related institutes; nationwide tour lecture plan Regional conference plan: annual meeting sponsor plan of related institutes from leading markets; regional tour lecture plan Sales representative promotion tool and brand prompt preparation based on product positioning Sales team product training plan and execution Marketing Execution ： Product conception spread and sales promotion plan of market department based on product research and product strategy Successful case of market introduction and sales 17

Establishing sales plan based on market strategy and execute the plan:  Confirmation and decomposition of sale index  Confirmation and decomposition of sales budget  Establishment and execution of working standard for sales manager/representative  Confirm list of objective hospital and hospital development plan and execution  Confirm objective doctor standard and objective doctor development plan and execution  Working content training of sales representative Slide lecture training Training of product leaf use Training of face-to-face visiting  Sales promotion plan and execution Establishment and execution of round-table conference and department slide lecture plan Regional conference plan: annual meeting sponsor plan of related institutes from leading markets; regional tour lecture plan Establishment and transmission of sale team incentive plan based on marketing strategy Tracing of sale team action: good result can be obtained only after good plan is performed Marketing execution: Product conception spread and sales promotion plan of market department based on product research and product strategy Successful case of market introduction and sales 18

Remark : The product was introduced in 2004 and swift growth was maintained in the consecutive 3 years. It maintains the first market share in four like products launched in Sales Curve for Rat Nerve Growth Factor Unit: piece Unit: piece Successful case of market introduction and sales 19

Look forward ---- Just do it ! Screen and finalize drug or medical device We do the market potential and forecast We sign registration agreement We sign distribution agreement after getting SFDA approval We enter the market and sell We grow together We succeed together! Contact: Georges Zhang Shanghai sales center: Floor 1, Bldg G, Shanghai Info Park, 1188 WanRong Road Factory: No. 380 BaLing East Road, Yueyang City, HuNan province Thank you 20