Dr. Gail P. Taylor UT San Antonio 02/28/2013.  Student Conference Presentation  15 minute presentation ◦ 10 Minutes Talk ◦ 5 minutes for questions ◦

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Presentation transcript:

Dr. Gail P. Taylor UT San Antonio 02/28/2013

 Student Conference Presentation  15 minute presentation ◦ 10 Minutes Talk ◦ 5 minutes for questions ◦ At most, 15 slides

 Title Slide: Strong title, your name, mentor, school.  Introduction/Background (2-3 slides). ◦ Why/How is your topic important (health?) ◦ Give brief literature background (broad to specific) ◦ Goals of project ◦ Hypothesis  Methods and exptl design (1 to 2 slides- flowcharts good)  Results (1 – 2 experiments) 2-3 slides  Summary/Conclusions ◦ Bulleted and refer back to hypothesis  Future Directions  Acknowledgements  Questions?

 Uniform Font  Uniform title size and position  Short phrases  ~Six lines per page  Story carried by images  Contrast between background and text  All text big (even on figs)

Ergot-Derived Substance-X Reduces Tumor Growth and Size in Nude Mice with MCF-7 Mammary Adenocarcinoma Emily P Frogbottom Undergraduate Research Trainee Research Mentor: Dr. Tenure Track University of Texas at San Antonio NOTE! I have Made up all of the data in this study.

Introduction – Breast Cancer 100,000 diagnoses annually 1 100,000 diagnoses annually 1 Leading cause of death in women Leading cause of death in women Vary in metastatic capacity Vary in metastatic capacity Vascularization required for growth/metastasis Vascularization required for growth/metastasis MCF-7: Human adenocarcinoma cell line MCF-7: Human adenocarcinoma cell line 1 Centers for Disease Control, 2010

Introduction –Treatment Generally surgery & chemotherapy Generally surgery & chemotherapy Mortality __% at 5 years 1 Mortality __% at 5 years 1 More effective chemotherapeutic agents needed More effective chemotherapeutic agents needed Some work by inhibiting vascularization 2 Some work by inhibiting vascularization 2 2 De Olivera, L, Hamm A, Mazzone M (2011) Mol Aspects Med Apr;32(2): Epub 2011 Apr 22

Introduction - Ergot Claviceps purpurea fungus Claviceps purpurea fungus “Cocktail” of active substances “Cocktail” of active substances CNS - Psychoactive Ergotamine ~LSD CNS - Psychoactive Ergotamine ~LSD Peripheral Effects – Peripheral Effects – –Tingling- “St. Anthony’s Fire” –Inhibit vascularization and promotes gangrene Vasoactive Substance-X isolated 3 Vasoactive Substance-X isolated 3 –Inhibits growth of cultured endothelial cells 3 3 Taylor, GP (2011) Terrific thought experiment on using a deadly scourge to humanity to cure cancer. Journal of Positive Data 3(3),

Hypothesis MCF-7 tumor growth will be inhibited through treatment with vasoactive Substance-X. Inhibition will be associated with reduced angiogenesis MCF-7 tumor growth will be inhibited through treatment with vasoactive Substance-X. Inhibition will be associated with reduced angiogenesis

Experimental Design/Methods Culture Induction TreatmentAnalysis MCF-7 Cells DMEM 2 weeks <40% conf. Athymic mice N=40 (4 grps) SubQ Injection Thigh 10 6 /50ul 1 mo growth SubQ injections Control (solv) 1, uM SubX Daily for 8 wk Weekly caliper measurement 8 weeks sac Cryosection ICC anti-BV Density Test Stats – T-Test

Results P< 0.01 * ** * ** * * ** Substance-X Inhibited MCF-7 Tumor Growth

Results Control1 uM 10 uM 100 uM 200X * * Angiogenesis Inhibition

Conclusions Substance-X (10 uM – 100 uM) inhibits growth of MCF-7 tumors in athymic mice Substance-X (10 uM – 100 uM) inhibits growth of MCF-7 tumors in athymic mice Angiogenesis significantly inhibited at higher dosages Angiogenesis significantly inhibited at higher dosages Hypothesis retained Hypothesis retained Substance-X may be a powerful treatment against adenocarcinoma breast tumor growth Substance-X may be a powerful treatment against adenocarcinoma breast tumor growth

Future Directions Establish LD-50 curve Establish LD-50 curve Explore concentrations Explore concentrations Vary treatment schedules Vary treatment schedules Examine effects on metastasis Examine effects on metastasis Compare with standard chemotherapeutic agents Compare with standard chemotherapeutic agents

Acknowledgements Dr. U.R. Fakedata, UTSSSA Dr. U.R. Fakedata, UTSSSA Belinda Doolittle Belinda Doolittle Jason Trimple Jason Trimple MBRS-RISE GM MBRS-RISE GM MARC-U*STAR GM MARC-U*STAR GM 07717

Questions?