Pure Science. Innovative Thinking. Unparalleled Quality 1 “A PARTNERSHIP IN HEALTH & WELLNESS” SourceOne Global Partners.

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Presentation transcript:

Pure Science. Innovative Thinking. Unparalleled Quality 1 “A PARTNERSHIP IN HEALTH & WELLNESS” SourceOne Global Partners

Pure Science. Innovative Thinking. Unparalleled Quality 2 Presentation Agenda Introductions, SourceOne and Vesifact What is the VESIsorb ® delivery system How it works, the features and benefits “Seeing is believing” Providing science-based solutions… Global market leadership…

Pure Science. Innovative Thinking. Unparalleled Quality 3 SourceOne Global Partners “Our Success Insures Your Success” We provide health and wellness solutions, created through scientific research and innovative product development. Our focus is on clinically proven formulations, combined with technologically-advanced and patented delivery systems

Pure Science. Innovative Thinking. Unparalleled Quality 4 The SourceOne Difference SourceOne has distinguished itself as a premier innovator of scientifically proven health products and technologies. Our leadership team has forged numerous global partnerships and alliances resulting in competitive advantages and added value to the portfolio we bring to the global marketplace. The synergies created by these partnerships are directly and immediately applicable to the new products we are introducing and those we are developing. The many benefits derived from these innovations and the technology exchange will resonate with our client partners and ultimately the consumer focused on health and wellness.

Pure Science. Innovative Thinking. Unparalleled Quality 5 Exclusive Partnership with World Leader in advanced delivery systems Through SourceOne’s exclusive partnership with Vesifact, a world leader in micro emulsions, nano-colloids, drug delivery, and other innovative delivery systems, we are a leading solution provider for dramatically improving absorption and bioavailability of poorly absorbed ingredients.

Pure Science. Innovative Thinking. Unparalleled Quality 6 Vesifact Swiss Precision, Closed Loop Sterile Production Facility

Pure Science. Innovative Thinking. Unparalleled Quality 7 The latest breakthrough is VESIsorb® What is VESIsorb ® ? A naturally self-assembling colloidal delivery system that enables us to meet the growing demand for enhanced bioavailability of unique science-based formulas taking their absorption and efficacy to the next level.

Pure Science. Innovative Thinking. Unparalleled Quality 8 Self-Assembling Delivery System VESIsorb ® keeps water insoluble respectively fat soluble molecules in a hydrophilic environment (e.g. water, gastric fluids) in solution. VESIsorb ® does not change a molecule chemically. It is a solubilizing vehicle comprising an oil core surrounded by a monolayer membrane (emulsifiers). These emulsifiers link the two surface areas between water and oil. Without “linking molecules”, it is impossible to get a stable oil/water mixture (emulsion). This is a dynamic process, no static, and it allows the molecules (emulsifiers, oils, actives) to move perpetually from one droplet to another or other membranes (e.g. enterocytes).

Pure Science. Innovative Thinking. Unparalleled Quality 9 VESIsorb®…Three Step Process

Pure Science. Innovative Thinking. Unparalleled Quality 10 Advantages in Technology Non-aqueous lipid-based composition containing an active ingredient On contact with an aqueous phase a colloidal delivery system containing the active ingredients is spontaneously formed (self- assembling) Superior Characteristics of the colloidal delivery system Size <100nm, typically <50nm Highly uniform size distribution Colloidal solubilized active “H 2 O” CoQsource ®

Pure Science. Innovative Thinking. Unparalleled Quality 11 Patented All-Natural Delivery System CoQ10 (Ubiquinone) CoQ10 Pre-Colloid Phase CoQ10 Colloid Phase CoQsource ®

Pure Science. Innovative Thinking. Unparalleled Quality 12 Micelle vs. Liposome vs. Colloidal Delivery System Liposome Shell: Bi-Layer Core: Water Colloidal Shell: Mono-layer Core: Oil Micelle Shell: Hydrophilic surfactant head Core: Hydrophobic surfactant tail

Pure Science. Innovative Thinking. Unparalleled Quality 13 CoQ10 Bio-enhanced formulations compare absorption data to CoQ10 powders 3 studies show peak absorption of CoQ10 powder of.51,.85 and 2.15 average = studies using soft gels in oily dispersion show peak absorption…1.32, 1.76 and 1.98 average = studies various delivery systems… 2.24, 3.57, and 4.48 average = 3.43 VESIsorb® colloidal droplet peak absorption… 16.97

Pure Science. Innovative Thinking. Unparalleled Quality 14 Published Study Results The graph above provides a vivid illustration of the difference in CoQsource ® (orange line) versus the three other “bio- enhanced” CoQ10 products in plasma concentration levels after one hour, but continues to increase dramatically before reaching Cmax at about 4 hours. The plasma concentration of CoQsource ® remains well above the levels of the 3 other treatments throughout the 23 hour period.

Pure Science. Innovative Thinking. Unparalleled Quality 15 Consistent Clinical Results CoQ10 Ubiquinone & Ubiquinol-QH

Pure Science. Innovative Thinking. Unparalleled Quality 16 Consistent PK Results Omega-3 EPA/DHA OmegaChoice ® in the VESIsorb ® delivery system turns concentrated Omega-3 EPA/DHA into water soluble colloidal droplets increasing absorption and broadening the possible applications. A pharmacokinetic pilot study comparing OmegaChoice ® 90 Concentrated Omega-3 EPA to the same OmegaChoice ™ 90 in the VESIsorb® delivery system demonstrated an increase of 567% in peak blood levels (cmax) of EPA. The relative bioavailability calculated using the area under the curve (AUC 01-12h) was also increase by 487%.

Pure Science. Innovative Thinking. Unparalleled Quality 17

Pure Science. Innovative Thinking. Unparalleled Quality 18 Consistent advantage of optimal performance under all conditions Absorption & bioavailability impacted by –Aging population = nutrient absorption declines with age –Low-Fat Diet…see Omthera study Lovaza vs. Epanova –Sickness & Stress negatively impact absorption –More standard capsules = < efficient absorption Delivers Maximum Benefits

Pure Science. Innovative Thinking. Unparalleled Quality 19 COMPETING CoQ10 PRODUCT DOES NOT GO INTO SOLUTION OIL DROPS SITTING ON WATERSEPARATION OF COMPONENTS (NO EMULSIFICATION) COLLOIDAL DROPLET FORMATION100% IN SOLUTION! COMPLETELY HOMOGENOUS COLLOIDAL SOLUTION!

Pure Science. Innovative Thinking. Unparalleled Quality 20 STANDARD TG OMEGA-3 PRODUCT OIL DROPS SITTING ON WATER DOES NOT GO INTO SOLUTION SEPARATION OF COMPONENTS (NO EMULSIFICATION) COLLOIDAL DROPLET FORMATION 100% IN SOLUTION! COMPLETELY HOMOGENOUS COLLOIDAL SOLUTION!

Pure Science. Innovative Thinking. Unparalleled Quality 21 Leading CoQ10 and QH Ubiquinol Supplement Brands

Pure Science. Innovative Thinking. Unparalleled Quality 22 Homogeneous Delivery System Homogenous versus Heterogeneous Speed of conversion Stability Reproducibility for consistency at the consumer level SourceOne TocoSource® vs. Patented Competitive Tocotrienols

Pure Science. Innovative Thinking. Unparalleled Quality 23 VESIsorb® Fluid Droplets - Cryo Electron Micrograph

Pure Science. Innovative Thinking. Unparalleled Quality 24 VESIFACT HOLDS OVER 40 INTERNATIONAL PATENTS AND PATENTS-PENDING IN OVER 20 COUNTRIES Vesifact Intellectual Property (IP) and Know How

Pure Science. Innovative Thinking. Unparalleled Quality 25 The following listing is an overview of key U.S and European VESIsorb® oral and topical patents for both pharmaceutical and nutraceutical formulations. Additionally we have patents and patents pending in Japan, China, Hong Kong, Korea, Singapore, Brazil, India, Indonesia, Mexico, Philippines, Russia, Thailand, Taiwan and Argentina. Vesifact Patents & Patent Applications: Europe patent 1,249,502…”Microemulsion-preconcentrates, microemulsions and use of such a composition” Europe patent 1,249,230…”Microemulsion-preconcentrates, microemulsions comprising coenzyme Q10” for oral and topical application Europe patent 852,941…”Nanodispersion cosmetic composition” for topical applications ; any cosmetic active is a candidate U.S. patent 5,997,888…”Cosmetic preparations” for improved absorption in topical applications; any cosmetic active is a candidate Europe patent 1,249,231…”Pharmaceutical formulations containing anti-inflammatory active ingredients and the use of said formulations” Europe patent 956,851…”Use of nanodispersions in cosmetic end formulations” for improved absorption in topical applications; any cosmetic active is a candidate U.S. patent 7,008,638…”Use of nanodispersions in cosmetic end formulations” Europe patent 956,853…”Use of nanodispersions in pharmaceutical end formulations for oral and topical applications of any pharmaceutical ingredients” U.S. patent 7,081,253…”Use of nanodispersions in pharmaceutical end formulations for oral and topical applications of any pharmaceutical ingredients”

Pure Science. Innovative Thinking. Unparalleled Quality 26

Pure Science. Innovative Thinking. Unparalleled Quality 27 What Do Consumers Want? To take fewer capsules To take smaller capsules To receive the maximum benefits from their supplements Greater bioavailability & absorption …Withis more!

Pure Science. Innovative Thinking. Unparalleled Quality 28 The VESIsorb® Solution With VESIsorb ®, you need less to achieve more. Fewer soft gels in your daily regimen to achieve better results. Size Matters =

Pure Science. Innovative Thinking. Unparalleled Quality 29

Pure Science. Innovative Thinking. Unparalleled Quality 30 By increasing bioactive absorption, like CoQ10, this in turn reduces the number of soft gels needed per day to achieve blood plasma levels for optimum health and wellness. VESIsorb® technology has a green impact on the environment. The efficient use of resources results in fewer bottles, less packaging waste and reduced transportation needs.

Pure Science. Innovative Thinking. Unparalleled Quality 31 Patented, clinically proven formulations in leading brands

Pure Science. Innovative Thinking. Unparalleled Quality 32 Advanced Innovative technologies

Pure Science. Innovative Thinking. Unparalleled Quality 33 Summary

Pure Science. Innovative Thinking. Unparalleled Quality 34