曹广文主任、教授第二军医大学流行病学教研室

Slides:

Advertisements

Similar presentations

DrMohammadSadrkabir Editor:. FREQUENCY OF ELEVATED HEPATOCELLULAR CARCINOMA (HCC) BIOMARKERS IN PATIENTS WITH ADVANCED HEPATITIS C The American Journal.

Advertisements

Infectious hepatitis Clinical manifestations: Asymptomatic Acute Chronic Asymptomatic carrier Hepatic failure Cirrhosis Hepatocellular carcinoma.

1. Interpret a positive HBeAg, Anti- HBcAg, and/or anti-HCV test.

HistCite 结果分析示例罗昭锋. By:SC 可能原因：文献年度过窄，少有相互引用.

Hepatitis B: Epidemiology

Hallauer 06/20011 Outcome evaluation of an universal hepatitis B immunisation programme Johannes F. Hallauer M.D. Health Systems Research Charité, Humboldt.

小鹅瘟 Gosling plague. 雏鹅的急性败血性传染病雏鹅的急性败血性传染病发生渗出性肠炎、下痢发生渗出性肠炎、下痢传染快、死亡率高传染快、死亡率高.

1 第三章管理环境一、外部环境因素一、外部环境因素二、内部环境因素二、内部环境因素三、当代的管理环境特点三、当代的管理环境特点.

兽医病理生理学 veterinary pathophysiology. Anatomy Histology PhysiologyBiochemistry Pathological Anatomy Pathological Physiology Pathological Biochemistry Normal.

兽医病理生理学 Veterinary Pathophysiology. 一、概念 (Definition or concept) ：兽医病理生理学是研究动物疾病发生的原因和条件，研究疾病全过程中患病体的机能、代谢的动态变化及其机制，揭示疾病发生、发展和转归的规律，阐明疾病的本质，为疾病的防治提供理论依据。

Epidemiology of hepatitis B in Ireland Updated August 2014

Development of Sci B Vac: a Pre-S 1 /Pre-S 2 /S Hepatitis B Vaccine Daniel Shouval Liver Unit Hadassah and Hebrew University JerusalemIsrael.

Epidemiology and Control Programs for HBV Infection. Yousef Qari, MD, FRCP(C), ABIM Gastoenterologist King Abdulaziz University Hospital.

序號 3. 王秩秋校友獎項分類：學術卓越類畢業系別：物理學系入學年度： 1969 年推薦單位：物理系.

Hepatitis C: A Global Time Bomb

 Primary liver cancer is the fifth most common cancer in the world and the third most common cause of cancer mortality  Hepatocellular carcinomas (HCCs)

Hepatitis Viruses Chapter 35. Properties of Hepatitis Viruses Six known Hepatitis type A virus (Picornaviridae) Hepatitis type B virus (Hepadnaviridae)

HEPATITIS A VIRUS Week Response Clinical illness ALT IgM IgG HAV in stool Infection Viremia EVENTS IN HEPATITIS A VIRUS INFECTION.

National policy on Hepatitis B at the Workplace

Hepatitis B Virus 28.

Epidemiology and Prevention of Viral Hepatitis A to E: Hepatitis D (Delta) Virus Division of Viral Hepatitis.

Hepatitis LINK Viral Hepatitis is a group of disease that infect the liver. Three viruses - Hepatitis A, Hepatitis B and Hepatitis C are the most frequent.

World Hepatitis Day 2013, 29 th July Establishing a framework for better data collection and surveillance of Hepatitis in South Africa N. Prabdial-Sing.

L/O/G/O Unit 8 Is Biotechnology our Friend or Enemy?

Overview National Hepatitis B Data

Why we are here? However, a general lack of understanding exists among health-care professionals regarding the interpretation of screening test results,

Hepatitis A and B Dr. Amanj Saeed MBCHB, MSc, PhD

Research on HBV in SCDC Xi Zhang, Ye Lu Shanghai Municipal Center for Disease Control and Prevention May, 2008.

INTRODUCTION High incidence rate High incidence rate Do not grow in the laboratory Do not grow in the laboratory Discovered in 1964 Discovered in 1964.

Hepatitis B Virus Dr R V S N Sarma., M.D., [SLIDE 1] Title Slide

ACUTE VIRAL HEPATITIS CLINICAL PRESENTATION. DIGNOSIS. EPEDEMOLOGY OF VIRAL HEPATITIS INFECTION A,B,C IN KSA. MANAGEMENT.

HBV genotyping 12/21/07 Carrie Marshall. Received a send-out request for HBV genotyping on a 52y man.

ACUTE VIRAL HEPATITIS CLINICAL PRESENTATION. DIGNOSIS. EPEDEMOLOGY OF VIRAL HEPATITIS INFECTION A,B,C IN KSA. MANAGEMENT.

اعداد / يوسف عبدالله الشمراني اشراف / د 0 هشام ابو عوده.

Introduction of Department of Molecular Biology for Public Health in SCDC Ye Lu Shanghai Municipal Center for Disease Control & Prevention Shanghai Institute.

凤凰县文化旅游经济开发区工业加工体验园简介园区招商办公室二零一五年八月. 张家界荷花机场铜仁 · 凤凰机场常德桃花源机场凤凰文化旅游经济开发区湘西机场 ( 在建 ) 怀化芷江机场区位交通机场方面.

IB Biology Introduction June ( 孔珺 ) Tel:

我院召开《三级综合医院评审标准（ 2011 年版）内涵》讲座. 3 月 2 日，山东大学第二医院质量管理办公室徐玉华主任为我院带来一堂精彩的《三级综合医院评审标准（ 2011 年版）内涵》讲座。她用形象生动的事例全面介绍了三级医院达标的方方面面，大家听后受益匪浅。工会主席周文亮指出，全院要本照三级医院标准.

胰腺癌的 CT 、 MR 诊断（ Pancreatic Carcinoma ： CT&MR—based Detection ）孙泓泓（ H.H Sun ）副教授西安交通大学医学院第二附属医院医学影像科.

Hepatitis B The Basics David Wong University of Toronto March 2005.

Hepatitis Virus. Primary members HAV HBV HCV HDV HEV.

目标与要求：让学生了解材料美是布的基本特点，利用布的特点进行创作，培养学生的创新和实践能力。

A lesson plan 制作人 : 外语系 03 本 (1) 班田亚男. Welcome back to school! What about your holiday ? Are you happy? What did you do in your holiday?

开放教育学员入学须知第一部分：浏览山东理工大学远程与继续教育学院网站浏览山东理工大学远程与继续教育学院网站第二部分：浏览中央电大教学平台浏览中央电大教学平台第三部分：浏览山东电大教学平台浏览山东电大教学平台第四部分：浏览淄博电大教学平台浏览淄博电大教学平台第五部分：淄博电大教学平台使用淄博电大教学平台使用.

Unit 1 Great Scientists.

八. 真核生物的转录㈠特点 ① 转录单元为单顺反子（ single cistron ），每个蛋白质基因都有自身的启动子，从而造成在功能上相关而又独立的基因之间具有更复杂的调控系统。 ② RNA 聚合酶的高度分工，由 3 种不同的酶催化转录不同的 RNA 。 ③ 需要基本转录因子与转录调控因子的参与，这.

HBV Factors and Clinical Outcomes M Omata. Genotypes in China and Japan.

Evaluation of Hepatitis B surveillance system in Armenia, 2014 AUTHORS Karine Gevorgyan Lusine Paronyan Shushan Sargsyan Artavazd Vanyan NCDC, Armenia.

参展主要内容以信息科技支撑现代农业为主题，包括精准农业、数字农业、农业物联网、农业遥感、信息服务 5 部分内容，重点展示科研院所、大专院校等单位的科研成果及应用示例。精准农业重点展示面向设施、果园、大田生产管理过程中的关键技术及智能装备，以精准施肥、施药、灌溉大型机具实物展示为主，同时将搭建微型温室（约.

Serologic markers and molecular epidemiology of HBV from an HIV infected cohort from Cameroon Tshifhiwa Magoro 1, Emmaculate Nongpang 2, Lufuno Mavhandu.

Prevention of Viral Hepatitis B in Republic of Korea Ok Park, M.D., Ph.D., MPH Vaccine-Preventable Disease Control & National Immunization Program Korea.

Viral Hepatitis.

Th1/Th2细胞因子在感染中的意义浙江大学附属儿童医院宁铂涛.

Volume 130, Issue 4, Pages (April 2006)

Dr Iyat Abdul Sattar A study on the clinical & serolological markers of HBV among patients with chronic HBV infection in Babylon Dr Monem Makki Alshok.

ACUTE VIRAL HEPATITIS CLINICAL PRESENTATION. DIGNOSIS.

Serologic diagnosis of HBVinfection

HCV. The Spectrum of Hepatitis C Virus Infection: From Acute Infection to End-Stage Liver Disease.

Viruses and Cancer.

Division of Viral Hepatitis

Hepatitis B and C virus-related carcinogenesis

Introduction The American Journal of Medicine

第四节泊肃叶定律 1 、泊肃叶定律 Poiseuille law 法国医生泊肃叶研究了血管中血液的流动。经实验研究表明：不可压缩的粘性流体沿水平圆管作层流时，通过的流量与加在管道两端的压强差成正比, 与圆管的半径的四次方成正比，与圆管的长度成反比。于 1842 年正式发表了此结果。 1852.

How viral genetic variants and genotypes influence disease and treatment outcome of chronic hepatitis B. Time for an individualised approach? Neil Rajoriya,

Volume 130, Issue 4, Pages (April 2006)

Hepatitis B and C virus-related carcinogenesis

H. Leblebicioglu, C. Eroglu Clinical Microbiology and Infection

Jia-Horng Kao*, Pei-Jer Chen*, Ming-Yang Lai*, Ding-Shinn Chen‡,§

Presentation transcript:

曹广文主任、教授第二军医大学流行病学教研室 Clinical relevance and public health significance of hepatitis B virus genomic variations 曹广文主任、教授第二军医大学流行病学教研室

Geographic distribution of HBV genotypes A-J

Entry of hepatitis B virus slow replication strong replication immune defence Delayed, vigorous immune response immunotolerance, inapparent, chronic inapparent transient infection acute fulminant incomplete response efficient inefficient HBsAg carrier chronic hepatitis immunity recovery cirrhosis carcinoma

donor, immuno-selection aa-sequence of S-loop

Genotype specific residues in the a determinant of SHBs

Model of the HBsAg loop (99-161) : escape mutations in an anti-HBs negative, infectious blood donor I a-determinant C121-C148 L L E G145K T

Luciferase activities 截短型与野生型HBx在细胞水平的不同功能 Transactivation Cell Growth 80000 50 100 150 200 250 300 350 pcDNA3.1 HBx HBx∆8 HBx∆11 HBx∆14 HBx∆16 HBx∆18 Colonies Chang 70000 a-ML 60000 Luciferase activities 50000 40000 30000 20000 10000 pcDNA3.1 HBx HBx∆8 HBx∆11 HBx∆14 HBx∆16 HBx∆18 x pcDNA3.1 10 20 30 40 50 60 pcDNA3.1 HBx HBx∆8 HBx∆11 HBx∆14 HBx∆16 HBx∆18 Foci REF Transformation x∆8 x∆11 x∆14 x∆16 x∆18

Transcription factors binding to HBV Enhancer II/Core-promoter

WJG 2009; 15(46):5761-5769 （曹广文）

HCC全球死亡率 (Gastroenterology 2007;132:2557-76)

Vaccination and prevalence Vaccination rate (%) HBsAg prevalence (%) Age (years old)

第二军医大学流行病学专业在HBV方面工作 Journal of Clinical Virolology 2007; 38:238-243（通讯作者：曹广文）.

Cancer Epidemiology, Biomarkers & Prevention 2010;19(3):777-86 （通讯作者：曹广文）

Gut 2008;57(12):1713-20 （通讯作者：曹广文）

Carcinogenesis 2008;29(9):1685-91 （通讯作者：曹广文）

WJG 2010; 16(3):378-82 （通讯作者：曹广文）

Journal of National Cancer Institute 2009;101(15):1066-82 （通讯作者：曹广文）

American Journal of Gastroenterology 2010 in press （通讯作者：曹广文）

Journal of Gastroenterology 2010 in press（通讯作者：曹广文）

Journal of Medical Viology 2010 in press（通讯作者：曹广文）

Carcinogenesis 2009;30(11):1916-1922 （通讯作者：曹广文）

The important thing is not to stop questioning Albert Einstein 1. How to predict HCC? 2. What kinds of clinical protocol feasible for stopping the progression into HCC? 3. How long does HBV accompany with human evolution? 4. Is there any genetic predisposition for HBV?

Thank you！