The National Association for Pancreatic Cancer Prese nts.

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The National Association for Pancreatic Cancer Prese nts

This Year… 3% of the population, over 43,000 people, will be diagnosed with pancreatic cancer. Over 37,000 people will die from the disease.

What is Cancer? Alison and Sarraf, Understanding Cancer, Cambridge University Press, 1997

Cancer Trends

Cancer Survival

P53 is a Regulator of Apoptosis External pathway – External pathway – induced by exposure to chemical signals released by other cells – are “death signals” From L. J. Kleinsmith, Principles of Cancer Biology. Copyright (c) 2006 Pearson Benjamin Cummings. Death signals activate death receptors Internal pathway – Internal pathway – induced by excessive DNA damage Leaches from mitochondria & activates caspase cascade

Prevalence of p53 Mutations From L. J. Kleinsmith, Principles of Cancer Biology. Copyright (c) 2006 Pearson Benjamin Cummings. p53 is the most commonly mutated gene in human cancers

The Chemotherapy Industry In 2003, worldwide market for products was ~$36.8 billion US Currently, oncology-related products represent ~10% of total $430 billion worldwide market for pharmaceuticals (Pharmaceutical Therapeutic Categories Outlook: Comprehensive Study 375, S.G. Cowan & Co., NY, 2004) Market expansion driven by: Increased therapeutic options Willingness to treat older patients High price of newer drugs At present, more than 1,300 small U.S. biotech companies focused on molecular target drug development, >50% cancer focused

Is Timing Everything? Figure 16.9 The Biology of Cancer (© Garland Science 2007) PanINs = pancreatic intraepithelial neoplasias are discrete stages in tumor progression

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