- A physical change in the skin caused by a disease process in the sebaceous follicle - Acne is the term for plugged pores (blackheads and whiteheads), pimples, and even deeper lumps (cysts or nodules) that occur on the face, neck, chest, back, shoulders and even the upper arms Types of Acne Comedo, papule, pustule, nodule and cyst. Sebaceous glands: Glands in the skin that produce an oily substance called sebum--these glands are the sites of acne lesions. Sebaceous glands are attached to hair follicles and are found mostly on the face, neck, back and chest. Sebum: The oily substance produced by sebaceous glands. - A physical change in the skin caused by a disease process in the sebaceous follicle - Acne is the term for plugged pores (blackheads and whiteheads), pimples, and even deeper lumps (cysts or nodules) that occur on the face, neck, chest, back, shoulders and even the upper arms Types of Acne Comedo, papule, pustule, nodule and cyst. Sebaceous glands: Glands in the skin that produce an oily substance called sebum--these glands are the sites of acne lesions. Sebaceous glands are attached to hair follicles and are found mostly on the face, neck, back and chest. Sebum: The oily substance produced by sebaceous glands.

Classification of Acne Vulgaris Obstructive Acne Open Comedones (Black heads) Closed Comedones (White heads) Inflammatory Acne (in order of lesion formation) Scars

Acne occurs when androgen hormones cause sebaceous glands to grow and produce more sebum. In concert with this change, there are changes in the skin lining the hair follicle to which sebaceous glands are attached. The skin cells of the follicle lining shed more quickly, in clumps, and are sticky. These cells and increased sebum output are likely to cause clogged pores that can become comedones. Finally, a kind of bacteria, P. acnes, which is a normal resident on the skin, invades the clogged follicle and begins to multiply rapidly. The result is acne in all its forms. Mechanism

Drugs used in Acne Isotretinoin Azelaic Acid Clindamycin Topical Erythromycin Topical Tetracycline Topical Benzoyl Peroxide Tretinoin Given the way acne occurs, acne treatments do one or more of the following: Reduce sebum production Reduce P. acnes Normalize the shedding of skin cells Acne Treatment

 Cholera is a severe diarrheal disease caused by the bacterium Vibrio cholerae.  The toxin released by the bacteria causes increased secretion of water in the intestine, which can produce massive diarrhea.  Various countries have weaponized cholera toxin for ChemBio warfare

Cholera is one of the most rapidly fatal illnesses known. A person may become hypotensive within an hour of the onset of symptoms and may die within 2-3 hours if not treatment is provided. More commonly, the disease progresses from the first liquid stool to shock in 4-12 hours, with death following in 18 hours to several days Severe dehydration can cause death. Given adequate fluids, most people will make a full recovery. Caused by cholera toxin, a G protein inhibitor.

Hot flashes Dryness Profound depression

Osteoporosis definition A systemic skeletal disease characterized by low bone mass and micro-architectural deterioration of bone tissue with resultant increase in fragility and risk of fracture Bone strength depends on bone density and bone quality