Beyond Oral Agents & Insulin: New Frontiers in the Management of Diabetes and Cardiometabolic Risk A Primary Care Initiative.

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Presentation transcript:

Beyond Oral Agents & Insulin: New Frontiers in the Management of Diabetes and Cardiometabolic Risk A Primary Care Initiative

Learning Objectives Describe the role of incretin physiology in diabetes and diabetes treatmentDescribe the role of incretin physiology in diabetes and diabetes treatment Explain the mechanism of action of the incretin mimeticsExplain the mechanism of action of the incretin mimetics Identify the role of glucose metabolism in addressing cardiometabolic riskIdentify the role of glucose metabolism in addressing cardiometabolic risk Integrate incretin mimetics in clinical practiceIntegrate incretin mimetics in clinical practice

Therapy for Type 2 Diabetes (T2DM): Sites of Action Pancreas LiverMuscles Gut Gut Thiazolidinedione Exogenous insulin Biguanides Incretin mimetics Amylin analogues Hyperglycemia Incretin mimetics Alpha glucosidase inhibitors Incretin mimetics Amylin analogues Sulfonylurea Secretagogues

Clearly, we have many choices in diabetes management, and yet...

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Influenza-like Illnesses Vaccine(n=576)Placebo(n=554)PVaccine(n=582)Placebo(n=596)P Illnesses NS <0.001 Days Ill <0001 Physician Visits NS <0.001 Lost Workdays Patients With Lost Workdays NS <0.001 Effectiveness of Vaccination in Healthy Working Adults