Lung is a mechanical organ Built similar to pyramids (apex at top, base at bottom, with segments) Packaging problem (55% on R, 45% on L) Major properties are –Dry –Inflated

Segmental Anatomy: redundancy Purpose of segments –Prevent spread of infection –Prevent complete obstruction from an inflated foreign body Lobes have more than one segment (20 total) –Upper –Middle –Lower

Air is distributed in proportion to segmental volume Maintain volume similar to a submarine Ventilation is matched to volume: regional ventilation = regional volume

Move during sleep; give lungs negative pressure to prevent atelectasis: airlessness

Carina: branch point in the lungs Bronchiole tree is not symmetrical Food must pass from front to back and air from back to front –Can be problem in the old and the young –Glottis defends the airway

Larnyx: rigid, cartilagenous box Narrowest part of the system “V” is front: vocal cords Vocal cords move in synchrony with diaphragm

Trachea: ~ vacuum hose Posterior is muscle, anterior is cart. Rings Muscle allows ability to cough Posterior utilized to expel objects: blow gun or spit wad effect

COPD: chronic obstructive pulmonary disease Exhalation is restricted

RLD: restrictive lung disease Inhalation is restricted

Air moves across a pressure gradient

Muscles of inspiration (Active) Diaphragm External intercostals (bucket handles) Inspiration is active

Muscles of expiration (intercostals are stabilization) (usually passive): Rectus abdominus Obliques Lats

Diaphram originates in the chest wall and inserts on the central tendon: Three muscles, right, left costal, and cural components Criss-cross in the back to allow for the esphogus, vena cava, etc.

Flow is swirly, not turbulent, difficult to characterize the flow in the upper airways to simplify, assume Ohms law: Resistance (R) = change pressure/flow Or flow = change in pressure/R

Velocity (U = flow/area) Need low pressure for inspiration: 5 cm/H 2 O Inhale pressure has capacity for 120 cm/H 2 O Maximal inspiratory pressure (MIP) usually occurs at FRC (functional residual capacity), low lung volumes, usually about - 80 – cm/H 2 O MEP: occurs at high lung volumes, recoil of diaphragm ( cm/H 2 O) Due to length tension relationship

Disease states: greater pressure for adequate flow (obstructive airway disease)

Delta V t /Delta pressure = compliance High compliance: emphysema Increase pressure –Increase chest wall diameter –Compress abdominal space

Total Lung Capacity (TLC) determined by: Wt, gender, age, ht Compliance Surfactant Insp/expir. muscle strength

Conducting airways have cartilage, lower do not: interdependent

Alveoli are connected via smooth muscle and connective tissue: one opens, all open to prevent atelectasis

Mucosal clearance: similar to flypaper, lubricates and protects: Hydrates Provides protective surface Collect debris

Goblet cells: secrete sticky, tenacious mucous

Submucosal glands are less sticky, make islands

Debris is moved up on islands to carinas via cillia “beating” Clean from periphery to the central Mucocilliary escalator

Cystic Fibrosis: does not regulate sol (soluable) phase Cillia are too deep, below the surface, cannot beat effectively, bacteria can overgrow

Peripheral airways have laminar flow, allows for diffusion

Alveoli have pores for gas diffusion, collateral airflow

Two types of ventilation: Pulmonary: air is brought into lungs and exchanged with air in lungs (Ve) Alveolar: exchange of gases between alveoli and capillaries