Co-Occurring Disorders J. H. Shale, MD, JD Psychiatric Director Serenity House, Abilene, TX Clinical Prof. UCSD School of Medicine, San Diego, CA

Overview Definitions of terms Propositions Statistics Diagnosis v. Misdiagnosis Treatment

Definitions 1 Dual Diagnosis (DD) was an early term used for the presence of a mental disorder and a SADO DD has been used interchangeably with Co-occurring disorders and co-morbidity. But DSM IV TR also uses co-morbidity to describe two mental disorders in the same person And DSM IV TR does not define any of these terms Here we use any of these terms in the original sense Mental DO + SADO

Definitions 2 Serious persistent mental illness Public systems often have a limited spectrum of disorders that qualify for treatment LA and SD County and MHMR here in TX SCZ, SczAff DO, Bipolar DO and MDD, maybe BPDO and less often Anxiety DO’s SADO are usually treated in a parallel system if at all This has a huge impact on the quality of DX

Definitions 3 DSM Axis I = clinical disorders and SADO DSM Axis II = MR and PDO’s DSM III = general medical conditions DSM IV = Psychosocial/environmental problems DSM V = GAF This has a huge impact on the quality of DX

Proposition 1 Persons with SADO are at increased risk to develop mental disorders. Persons with mental disorders are at increased risk to develop SADO There is a clear consensus on this proposition, the only controversy is about the magnitude

Proposition 2 There is a major tendency to misdiagnose these co- occurring disorders. This results in both over and under diagnosis

Statistics The mark of a truly educated man is to be moved deeply by statistics. Geo. B. Shaw There are lies, damn lies and statistics Mark Twain

Problems getting good data Denial –Folks with SADO don’t tend to admit it Poor History taking –don’t ask, don’t tell Lack of experience and training in SADO Politics Confusion on rules for Dx – Tendency to over Dx –Rule of parsimony

Schizophrenia Lifetime Prevalence 1% - 1.5% Alcohol abuse/dep 24% Drug abuse/dep 14% Life expectancy 20% less than Gen pop Suicide rates > 15% Smoking 80 % Diabetes rates 1.5 times matched controls

Schizophrenia Dx A. Sx’s –delusions (bizarre), hallucinations, disorganized thinkng (speech/behavior, includes catatonia) neg sx’s of flat affect alogia, avolition. Active sx’s for at least a month B. social/occupational dysfunction C. Duration at least 6 months D. Exclusions: MDD, BPDO1, SczAffective DO E. Exclusions: SADO, gen med condition F. Relation to Autism/ Pervasive DDO –prominent Hallucination/Delusion for at least a month

Major Depressive Disorder Lifetime Prevalence 18% Early use of ETOH, tobacco, drugs increases risk of MDD and may cause earlier onset of MDD “former drinkers” at 4 fold risk of MDD in the period measured ( 1-4 yrs abstinent) Question is to what extent A causes B –Texas Sharpshooter Fallacy

Major Depressive Disorder Dx Sx’s 5 or more of following and 1 or 2 must be among them: 1.depressed mood, 2. Diminished interest –wgt change >5% in a month, insomnia/hypersomnia, psychomotor agitation/retardation, decreased energy, guilt/worthlessness, decreased concentration, recurrent thoughts of death/ SI/SA Exclude mixed episode (Dx of BPDO1) Sig interfere with major area of life function Not due to SADO, meds or med. Condition Sx’s are not form bereavement Sx’s duration > 2 month

Bipolar Disorder I Mania Distinct period at least a week of persistently elevated or expansive or irritable mood Sx’s 3 or more of: grandiosity/inflated self-esteem, decreased sleep, increased talk/pressured speech, thoughts racing/flgt of ideas, distractable, can’t focus, increase goal directed activity, psychmotor agitation, excessive involvement in sex, spending, or risk taking with potential for harm (poor jusdgment) exclude mixed episode (sx’s of both mania and dep) Sig interferes with major area of life function Excludes SADO or meds or Med condition

Bipolar Disorder in Clinical Populations 602 outpatients receiving treatment for unipolar depression with at least 1 failed antidepressant trial 19% screened positive* for bipolar disorder *Using the Mood Disorder Questionnaire (MDQ) The average number of failed antidepressants was 2.9 No significant differences seen in rate of positive MDQ screens based on # of failed antidepressants Patients Treated for Depression in Community Psychiatry Calabrese JR, et al. MedGenMed. 2006;8.

Bipolar Disorder Symptoms Are Chronic and Predominantly Depressive 53% 32% 9% 6% Asymptomatic Depressed Manic/hypomanic Cycling/mixed % of Weeks 146 bipolar I patients followed 12.8 years 86 bipolar II patients followed 13.4 years 46%* 50% 1% 2% Judd LL, et al. Arch Gen Psychiatry. 2002;59: Judd LL, et al. Arch Gen Psychiatry. 2003;60: *%s do not add to 100 due to rounding

Epidemiology Bipolar disorder is estimated to affect approximately 3.7% of the US population 1 Disease onset at 15 to 24 years of age, but accurate diagnosis may take 5 to 10 years 1,2 Equal incidence in men and women 2 1 Hirschfeld RMA, et al. J Clin Psychiatry. 2003;64: Evans DL. J Clin Psychiatry. 2000;61(suppl 13):26-31.

Epidemiology 15% to 20% of untreated patients succeed in committing suicide 1 High recurrence rate of bipolar disorder 2 High economic burden 2 Bipolar is a multidimensional disease 1,3 1 Evans DL. J Clin Psychiatry. 2000;61(suppl 13): Woods SW. J Clin Psychiatry. 2000;61(suppl 13): Goodwin FK, et al. In: Goodwin FK, Jamison KR, eds. Manic- Depressive Illness. New York, NY: Oxford University Press; 1990:74-84.

Bipolar Disorder: Unrecognized and Underdiagnosed 49% Not diagnosed as bipolar disorder or unipolar depression 31%Incorrectly diagnosed as unipolar depression 20% Correctly diagnosed by a doctor as having bipolar disorder 3.7% † Prevalence of bipolar I and II disorder* * Weighted to match national demographics † When adjusted for frequency of bipolar disorder in nonresponders Hirschfeld RMA, et al. J Clin Psychiatry. 2003;64: Mood Disorders Questionnaire Positive Rates (US Population)

Cross Addiction The APA Glossary, 8 th Ed defines cross- dependence: “ A drug’s ability to suppress physical manifestations of substance dependence produced by another drug and to maintain the physically dependent state. It provides the rationale for the treatment of dependence on one substance, such as alcohol, by the short-term substitution of a less dangerous and more controllable substance that is cross-dependent with alcohol (e.g. Librium, [chlordiazepoxide]) to treat the symptoms of alcohol withdrawal.”

Cross Addiction It has become a staple of teaching in addiction medicine that one should not use potentially addicting medications in patients with a history of substance abuse or dependence if it can be avoided.

Reasons For Misdiagnosis Problems getting good data Statistical issues and definitions of terms Payment mis-incentives Changing roles of “mental health professionals” Ignorance and sloth, maybe greed –TDPS: Harris county docs rank first in prescribing a combo of three highly addictive meds that give a “heroin high” –hydrocodone, alprazolam and carisoprodol –C.M. Schade, MD past president of TX Pain Society: No legitimate medical reason for this combo. (Temple Sentinel, B1, 6/1/10)