Synthetic Biology for Synthetic Drugs and Fuels Jay Keasling University of California, Berkeley Lawrence Berkeley National Laboratory.

Slides:

Advertisements

Similar presentations

An Institute of Local and Global Consequence Future of Biofuels in Alabama Larry Fillmer Auburn University.

Advertisements

Developing South Dakota’s Biorenewable Energy Economy –2010 Bioprocessing Center (CBRD) –Sun Grant Initiative –2010 Drought Center –Industry Partnerships.

Enough for all? Bernd Möller, Ph.D. Sustainable Energy Planning & Management Group Department of Development and Planning Aalborg University, Denmark Biomass.

James C. Greenwood President & CEO. The Future of Food and Fuel is Biotechnology.

Balancing Biomass for Bioenergy and Conserving the Soil Resource Jane Johnson USDA-ARS- North Central Soil Conservation Research Laboratory.

Sustainable, CO 2 -neutral Source of Energy.

Looking at the Economics of the Next Generation of Biofuels

Economic Impacts and Value- Added Benefits of Biofuel in the United States Hosein Shapouri United States Department of Agriculture Office of the Chief.

IOT POLY ENGINEERING 3-5 DRILL 24 JAN 2012 Which of the following data sets is the potential source for the pie chart below? A B C U.S. Energy Use 1996.

Risk Assessment and Economics of Forest Biorefinery Concepts USDA Forest Service Forest Products Laboratory Madison, Wisconsin.

Biomass for Biofuel.

APEC Biofuels Task Force Messages for Ministers Some Ideas for Discussion Sixth Meeting of the Biofuels Task Force Kuala Lumpur, Malaysia 29 April 2010.

Alternatives to Gasoline Possibilities and Capacities.

Economic Models of Biofuels and Policy Analysis John Miranowski,* Professor of Economics Iowa State University *With Alicia Rosburg, Research Assistant.

Opportunities and Challenges of Expanding Agriculture’s Contribution to the Energy Supply Daniel G. De La Torre Ugarte University of Tennessee.

Alternatives to Gasoline Possibilities and Capacities.

Economic and Land Use Implications of Biofuels: Role of Policy Madhu Khanna With Xiaoguang Chen and Haixiao Huang Department of Agricultural and Consumer.

1 The Biomass Program Office of the Biomass Program Energy Efficiency and Renewable Energy March 2, 2006.

Renewal Fuel from Biomass Waste UC Discovery/West Biofuels Research Project: “An Investigation of a Thermochemical Process for the Conversion of Biomass.

Alternatives to Gasoline Possibilities and Capacities.

Comparative Regional Economic Advantages for Cellulosic Feedstocks for Bioenergy Production. Burton C. English.

The Energy Bill, Biofuel Markets and the Implications for Agriculture Daniel G. De La Torre Ugarte Chesapeake College, Wye Mill, MD February 21, 2008 University.

The New World of Biofuels: Implications for Agriculture and Energy Keith Collins, Chief Economist, USDA EIA Energy Outlook, Modeling, and Data Conference.

Bio-Fuels Project & Industry Introduction Dr. Dawne Martin College of Business July 25, 2012.

World Feed and Food Supply and Demand Governors’ Agriculture, Energy, and Sustainability Roundtable Governors’ Biofuels Coalition Washington, DC January.

Biofuels Development Status and Potentials in Major Countries Michael Wang Center for Transportation Research Argonne National Laboratory Oct. 10, 2006.

ABFC2015 New Orleans, LA – June 9, 2015 Sorghum: An established crop for sustainable, global production.

Sustainability and Renewable Energy What’s our role?

1 BIOFUELS FROM A FOOD INDUSTRY PERSPECTIVE Willem-Jan Laan European Director External Affairs Unilever N.V.

F. Sijbesma, Chairman EuropaBio, MB DSM Lyon, April 10, 2003 White Biotechnology: Gateway to a More Sustainable Future.

Presented to: CFR 521 Elliott Schmitt Photos from

UK Renewable Energy Policy with particular reference to bioenergy

Presentation to Southern Bioenergy Summit Jim Decker Decker Garman Sullivan, LLC.

Economics of Cellulosic Ethanol Production Marie Walsh, Burt English, Daniel de la Torre Ugarte, Kim Jensen, Richard Nelson SAEA Annual Meeting Mobile,

Biomass Energy. Do you support the use of corn to produce ethanol as a fuel? 1. Yes 2. No.

Biofuels: A sober look at the potential Chris Field Carnegie Institution: Department of Global Ecology Stanford University, Department of Biology

GREEN CHEMISTRY: PROESA ® Technology to convert Biomass into Bio-based Chemicals Guido Ghisolfi.

An Overview of Biofuels UCLA Transportation - Land Use - Environment Connection Symposium Global Energy and Climate Change New Vehicles, New Fuels II:

Can we produce biofuels without affecting food production and the environment? The World Food Prize, Oct. 19, 2007 Birgitte K. Ahring BioCentrum-DTU &

Liberalization of Trade in Biofuels: Implications for GHG Emissions and Social Welfare Xiaoguang Chen Madhu Khanna Hayri Önal University of Illinois at.

Energy and Products from Agricultural Biomass: Prospects and Issues F. Larry Leistritz Donald M. Senechal Nancy M. Hodur Presented at: IAIA 2007 Conference,

Energy Information Administration Official Energy Statistics from the U.S. Government Annual Energy Outlook 2008 Energy Information Administration December.

In the Northwest Martin Tobias CEO & Chairman, Imperium Renewables Biofuels.

Semi-synthetic Artemisinin: A New Source of Artemisinin to Reduce Barriers to ACT Access November 18, 2008 London, UK Presented By Philippe Desjeux, PhD.

Office of the Chief Economist Office of Energy Policy and New Uses National Agricultural Credit Committee Harry S. Baumes Associate Director Office of.

Economic Research Service USDA Grains & Oilseeds Outlook Agricultural Outlook Forum 2012 Edward W. Allen U.S. Department of Agriculture Economic Research.

Biofuels: Impacts on Land, Food, and Prices Mark W. Rosegrant Director Environment and Production Technology Division AAAS Annual Meeting “Session on Biofuels,

“Food vs. Fuel” Controversy over Biofuels Charles V. Fishel, CEO Abundant Biofuels Corporation September 19, 2008.

American Energy Independence and Security Act of 2007 (EIS) and the global agriculture Yong Liu Department of Agriculture.

Global Biofuel Expansion under Different Energy Price Environments by May Mercado Peters Paper for presentation at the Energy Conference on “The Economics.

N O R T H C A R O L I N A B I O T E C H N O L O G Y C E N T E R North Carolina – State Initiatives Supporting the Bioenergy Industry Jacob Traverse NCBiotech.

Global Market Dynamics February 7, Commodity.

Bioenergy: Where We Are and Where We Should Be Daniel G. De La Torre Ugarte Chad M. Hellwinckel.

Dry Mill Ethanol Plants – Today’s Technology and Tomorrow’s Future.

Agenda n Introduction to Biofuels n Biotechnology can help make Biofuels cheaper n The next generation of biofuels and the US economy n Israeli biotechnology.

Agricultural Commodity Outlook Gerald A. Bange Chairperson World Agricultural Outlook Board Office of the Chief Economist U.S. Department of Agriculture.

Ethanol Fuel (Corn, Sugarcane, Switchgrass) Blake Liebling.

New technologies Professor Christine Raines Professor in Plant Biology University of Essex.

Department of Economics Biofuel Economics Intensive Program in Biorenewables Ames, Iowa June 9, 2009 Chad Hart Assistant Professor/Grain Markets Specialist.

Biofuels CENV 110. Topics The Technology Current status around the world – Supply and trends in production Impact Benefits Costs – Carbon balance – Net.

Tim Maker, Senior Program Director Biomass Energy Resource Center ENSURING FOREST SUSTAINABILITY IN THE DEVELOPMENT OF WOOD BIOENERGY IN THE US Pocantico.

Michael Metzlaff Crop Productivity Research Bayer BioScience, Gent, Belgium Oktober 2007.

Bioenergy Policies Chad Hart Center for Agricultural and Rural Development Iowa State University June 23, 2008.

 Meat  Population  Grain  Money  Water  Ethanol  Air  Temperature  Climate  Drought  Oil.

Session 4: Biofuels: How Feasible Are Large-Scale Goals for Biofuel Penetration in the US and Canada? Ken Andrasko, EPA Session Objectives: Gauge.

Biofuel Demand Projections In the Annual Energy Outlook

Bio-fuel crops and P fertilizer

The Future of Biological Products in Sustainable Agriculture

Adapted from John Gladden’s presentation

Presentation transcript:

Synthetic Biology for Synthetic Drugs and Fuels Jay Keasling University of California, Berkeley Lawrence Berkeley National Laboratory

Malaria

Chloroquine-based drugs Source: Roll Back Malaria World Malaria Report 2005

Artemisinin the best anti-malarial drug

Current process Artemisinin Plant synthesis Purification Artesunate Artelinate Arteether Artemether Chemical Conversions

Artemisinin demand analysis Source: Boston Consulting Group 247 in 2006 Malaria Cases (millions) GMAP target 135 in 2020 Total ACT Demand Millions of treatments ACTs delivered (actual) Demand forecasts from other groups BCG Demand forecast scenarios ACTs delivered

Artemisinin price swings Artemisinin prices ($/kg) Food prices (indexed to Jan 2002) Artemisinin prices Commodity food prices Source: Boston Consulting Group

Artemisinin supply Tonnes of Artemisinin Variable production Stock from previous year Historic production Demand Minimum production floor 09 Source: Boston Consulting Group

Current process Artemisinin Plant synthesis Purification Artesunate Artelinate Arteether Artemether Chemical Conversions

Microbial process Artemisinin Microbial synthesis Purification Artesunate Artelinate Arteether Artemether Chemical Conversions

Microbial synthesis of artemisinin

Improvements in yield  lower artemisinin costs Current cost of API$1.00/g Cost with new process$.10/g

Research, Development & Delivery Keasling Laboratory Amyris Biotechnologies

Global Warming and Energy Security

Petroleum-based transportation fuels CO 2

Corn to Ethanol CO 2

Corn to Ethanol CO 2

Corn to Ethanol

Corn is not an ideal energy crop Water requirements Fertilizer requirements Bred to be a food crop

CO 2 Biomass to Ethanol

US annual biomass inventory 1.3 billion tons Forest 12.8% Urban waste 2.9% Manure 4.1% Grains 5.2% Crop residues 7.6% Soy 6.2% Wheat straw 6.1% Corn stover 19.9% Perennial crops 35.2% From: Billion ton Vision, DOE & USDA 2005

5 6 7 Billion Barrels of Oil Equivalents US Imports 2007 US Domestic Productio n Fuel yields from biomass using mid-term conversion technology Energy from burning biomass How much fuel can we produce from 1.3 billion tons of biomass? 2007 US Petroleum Consumption 7.6

CO 2 Biomass to Ethanol

Ethanol is not an ideal fuel

Repurposing a microbial production platform

Biofuel

Engineered microbes produce oil and advanced biofuels

Biomass to advanced transportation fuels CO 2

The Joint BioEnergy Institute (jbei) CO 2

jbei: a Bay Area Partnership

jbei’s Research Program CO 2

jbei: a single location

jbei: an incubator for great ideas and the green economy Biofuels Companies Feedstock Companies Chemical Companies Petroleum Companies Plant Genetics Companies Biotech Companies