Pretreatment malnutrition and quality of life - association with prolonged length of hospital stay among patients with gynecological cancer: a cohort study Laky et al. BMC Cancer 2010, 10:232 99/11/28 鄒季臻

Abstract Background:  Length of hospital stay (LOS) is a surrogate marker for patients' well-being during hospital treatment and is associated with health care costs.  Identifying pretreatment factors associated with LOS in surgical patients may enable early intervention in order to reduce postoperative LOS. Methods:  This cohort study enrolled 157 patients with suspected or proven gynecological cancer at a tertiary cancer centre ( ).  Before commencing treatment, the scored Patient Generated - Subjective Global Assessment (PGSGA) measuring nutritional status and the Functional Assessment of Cancer Therapy-General (FACT-G) scale measuring quality of life (QOL) were completed. (FACT-G)  Clinical and demographic patient characteristics were prospectively obtained.  Patients were grouped into those with prolonged LOS if their hospital stay was greater than the median LOS and those with average or below average LOS.

Abstract Results:  Patients' mean age was 58 years (SD 14 years). Preoperatively, 81 (52%) patients presented with suspected benign disease/pelvic mass, 23 (15%) with suspected advanced ovarian cancer, 36 (23%) patients with suspected endometrial and 17 (11%) with cervical cancer, respectively.  In univariate models prolonged LOS was associated with low serum albumin or hemoglobin, malnutrition (PG-SGA score and PG-SGA group B or C), low pretreatment FACT-G score, and suspected diagnosis of cancer.  In multivariable models, PG-SGA group B or C, FACT- G score and suspected diagnosis of advanced ovarian cancer independently predicted LOS. 外科手術前 良性診斷 / 骨盆腫瘤疑後階卵巢癌子宮內膜癌子宮頸癌 人數 %

Abstract Conclusions:  Malnutrition, low quality of life scores and being diagnosed with advanced ovarian cancer are the major determinants of prolonged LOS amongst gynecological cancer patients.  Interventions addressing malnutrition and poor QOL may decrease LOS in gynecological cancer patients.

Background Previous research has shown that preoperative serum albumin (a marker of chronic malnutrition), hemoglobin and lymphocyte status are associated with LOS and mortality in the gynecological oncology setting. Malnutrition has been found to be associated with increased risk of morbidity and mortality, complication rates such as wound infections, costs of hospitalisation, and decreased QOL in various cancer populations. Using the PG-SGA, we have observed high levels of nutritional deficiencies among patients with gynecological cancer, especially those diagnosed with ovarian cancer. but to date no study has assessed whether the scored PG-SGA can predict prolonged LOS among gynecological cancer patients. Health-related QOL before treatment commences has been suggested as an important prognostic factor in ovarian cancer patients. To our knowledge, no study to date evaluated the association between preoperative QOL, malnutrition and LOS among a wider range of gynecological cancer patients.

Methods 2004/05~2006/12 primary gynecological 194 patients  excluded if they presented with recurrent cancer treatment for other cancers within the past five years impairments (e.g. schizophrenia, dementia) were non-English speaking 32 study participants declined(FACT-G) 5 participants had to be excluded from analyses due to incomplete data 157 women completed both the scored PG-SGA and the FACT-G questionnaire before commencing treatment. 6 women did not undergosurgery, because chemotherapy and/or radiotherapy treatment.

Methods Nutritional assessment  The scored PG-SGA is a validated nutritional assessment tool for cancer patients  Women were classified as well nourished (PG-SGA A); moderately malnourished or suspected of being malnourished (PG-SGA B); or severely malnourished (PG- SGA C).  The PG-SGA also incorporates a numerical score (PG- SGA score). with higher scores reflecting greater risk of malnutrition.

Methods QOL assessment  QOL was measured by the FACT-G questionnaire, which is a widely utilized and validated instrument.  Version 4 of the FACT-G is a 27-item self-report measure and allows patients to rate their current physical (7 items, range: 0-28), social and family (7 items, range: 0-28), motional (6 items, range: 0-24), and functional wellbeing (7 items, range: 0-28). The FACT-G is scored using a 5- point scale (0 = not at all, 1 = a little bit, 2 = somewhat, 3 = quite a bit, 4 = very much).

Methods Statistical analysis  Prolonged LOS was defined as LOS of greater than five days for patients who underwent open abdominal surgery and greater than two days for patients who underwent vaginal of laparoscopic surgery.  univariate: adjusted for age and surgical approach;  Multivariable: adjusted for albumin, FACT-G score, PG- SGA score and PG-SGA global rating; age and surgical approach.

Results Patient Characteristics  Patients' mean age was 58 years (SD 14 years). 外科手術前 良性診斷 / 骨盆腫瘤疑後階卵巢癌子宮內膜癌子宮頸癌 人數 % 治療剖腹手術內視鏡手術陰道手術化 / 放療 人數

Results

Discussion Malnutrition and low QOL were found to predict prolonged LOS independent of patients' age at diagnosis, surgical approach (laparoscopy or laparotomy), albumin and hemoglobin and suspected clinical diagnosis. Patients suspected to have stage III or IV ovarian cancer were also independently at greater risk for prolonged LOS compared to other patients. in our study the PG-SGA score was the weaker predictor compared to the global rating in multivariable analysis. Our findings show that LOS was not equally istributed between tumor types. Even after adjustment for age and surgical approach, 96% of all suspected advanced stage ovarian cancer patients had prolonged hospital stay, ompared with only 50% of patients with endometrial cancer and 42% of patients with a pelvic mass.

Discussion A previous study by Dean and colleagues found that gynecological cancer patients with two or more pre-existing co-morbidities had significantly longer LOS than those with one or no co-morbidities. Our findings suggest that in this sample of gynecological cancer patients, neither the number of co-morbidities nor the type of co-morbidity are predictive of prolonged LOS. In this study, we found low preoperative hemoglobin and lymphocyte counts in a small number of atients and these patients were more likely to experience prolonged LOS, but this difference was no longer statistically significant in adjusted modelling.

Discussion However, our current results demonstrated that when albumin and PG-SGA global rating were assessed concurrently, the PG-SGA was a stronger predictor of LOS, and therefore more sensitive to detect malnutrition in gynecological cancer atients. In the present study we found that poor QOL prior to initial treatment was associated with prolonged LOS, and this association remained significant when adjusted for other variables. A limitation of our study was that data on nutritional status and QOL were only assessed before commencement of initial treatment and not at any time point afterwards.

Conclusions prolonged LOS was found to be associated with low pre- surgical QOL and malnutrition. Strategies to reduce LOS and improve patients' well-being during hospital stay will need to address these potentially modifiable factors, particularly among women with suspected advanced ovarian cancer.