Cell Cycle Regulation & Cancer

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Presentation transcript:

Cell Cycle Regulation & Cancer

Normal Cell Cycle Cyclins: proteins CDKs (Cyclin dependent kinases): enzymes Cyclins and CDKs bind together to activate parts of the cell cycle

Normal Cell Cycle G1 checkpoint G2 checkpoint M checkpoint If something is wrong, cycle will STOP

ABNormal Cell Cycle CANCER: when cell cycle regulations fail Crowd out normal cells Spend less time in Interphase

ABNormal Cell Cycle Apoptosis:cell death( if damaged) Cancer: no apoptosis

Tumor: MASS OF CANCER CELLS TWO TYPES OF TUMORS Benign: stays contained Malignant: spread to nearby tissue or other organs

Why are Tumors bad? Angiogenesis: when tumors get a blood supply nutrients and oxygen go to tumor

Why are Tumors bad? Metastasis: pieces of tumor travel through blood to other organs

Causes of cancer Gene Mutations: changes in genes that control cell cycle What causes these mutations?

Cancer causes Carcinogens: cancer causing substances EX: tobacco smoke, asbestos Radiation EX: UV light from sun, X-rays

Cancer causes Virus EX: Human Papilloma Virus (HPV) Hereditary EX: breast Sporadic (no reason)

Treatments Prevention!!!!! Diet, exercise, healthy weight, no smoking, limit alcohol Screenings Catch it early! Mammograms Pap smear Colonoscopy

Treatments Surgery Remove tumor and surrounding tissue Radiation Directly kill tumor Chemotherapy Drug treatment

Incidence Rates: Male (From CDC) Female

Death Rates: Male Female

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