Cesar A. Hidalgo Center for Complex Network Research, University of Notre Dame / Northeastern University The Human Phenotypic Disease Network.

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Presentation transcript:

Cesar A. Hidalgo Center for Complex Network Research, University of Notre Dame / Northeastern University The Human Phenotypic Disease Network

Collaborators Nicholas Christakis Laurie Meneades Jason Block Dept. of Health Policy, Harvard Medical School Laszlo Barabasi Nicholas Blumm Deok-Sun Lee J Park Center for Network Science, Northeastern University Christine Teutsch Massachusetts General Hospital Harvard Medical School

Some Diseases are known to be related

ENPP1 HFCS SLS Ectonuclide Pyrophosphate Phosphodiesterase 1 High Fructose Corn Syrup Sedentary Life Style There are no single causes for each disease DiabetesObesity

Determining causes is labor and capital intensive

Disease 2Disease 1

Disease 2 Affect Same Individuals Significantly more than Random

C 12 P1P1 P2P2 N Building a Net

~ patients 58.3% females, 90.1% white 7.5% black ~ records (hospitalizations) Up to 10 diagnosis (from ~950 cat (3digit) / ~14000 (5digit) )

Disease 2 Disease 1

CHF

CONCLUSIONS We introduced the concept of a phenotypic disease network. This network can be used to help explore life cycle strategies for drug companies and hospital design. This network can be used to perform comparative studies. Ultimately, the goal is to help determine disease ontology based on their comorbidity patterns

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