TAMMY DO TRAUMA RESEARCH ASSOCIATES PROGRAM Necrosis

Premature death of cells/death of body tissue Apoptosis vs. Necrosis Caused by:  Infections  Toxins  Trauma  Ischemia

Causes Ischemia  Thrombosis/embolism Infection/Disease  Fungal/bacterial  Diabetes Chemicals  Poisons/toxins  venom Trauma

Necrotic Wound from Spider Bite

Types of Necrosis Coagulative Liquefactive Caseous Fatty Fibrinoid Gangrenous Aseptic

Coagulative Necrosis Caused by ischemia Denaturation of structural proteins Enzymatic digestion of cells Architecture of tissue preserved Occurs in organs like heart, spleen, kidney Does not occur in brain

Liquefactive Necrosis Necrotic tissue digested by enzymes into liquid Associated with abscess formation Commonly seen in brain  ischemia Fungal or bacterial infection  Not in brain

Caseous Necrosis Necrotic tissue is crumbly and cheese-like Typically caused by tuberculosis  Syphilis  fungal

Fat Necrosis In response to trauma Lipases break down fats React with calcium: saponification Chalky white deposits Most commonly seen in pancreas and breasts  Acute pancreatitis

Fibrinoid Necrosis Caused by deposition of fibrin or fibrin-like materials Vasculitis

Gangrenous Necrosis Considerable mass of necrosis Types of gangrene  Dry  Wet  Gas Dry Necrosis  Form of coagulative  Caused by ischemia  Autoamputation  Distal parts of limbs  Dry, shrunken, black

Gangrenous Cont. Wet  Moist tissue and organs  Characterized by bacterial infection  Dark, swollen, foul odor Gas  Bacterial infection that produces gas within tissue  Deadly

Gangrenous Cont.

Aseptic Necrosis Avascular necrosis or osteonecrosis Necrosis of bone Lack of blood supply to bone Medications, trauma, ischemia, hypercoagulable blood, alcoholism

Treatment Depends on the extent of damage Restoration of blood flow Maggot Therapy Debridement Amputation

Sources necrosis-liquefactive-necrosis-and-fibrinoid-necrosis necrosis-liquefactive-necrosis-and-fibrinoid-necrosis Diagnosed-Information-Diagnosis-Herceptin-Treated- necrosis-Diagnosed-Diagnosis.htm Diagnosed-Information-Diagnosis-Herceptin-Treated- necrosis-Diagnosed-Diagnosis.htm htm 6.htm necrosis/DS necrosis/DS html 29.html