“NHSBT strategic vision meeting” Dr. Les Russell - October Tel +44 (0) Confidential to OrganOx Limited

Current status Confidential to OrganOx Limited 1.Increasing donor numbers envisaged next 5 years 2.Increasing ratio of DCD and ECD donors 3.Increasing use of Type II donors 4.Current static cold preservation techniques  Worse outcomes with prolonged cold storage  Increased damage with steatotic organs  No means of viability assessment 5.Decreasing use of “marginal” organs where transportation is an issue 6.Established retrieval and transplant practices in many countries

“Improving the supply and quality of organs for transplantation” “Making untransplantable livers transplantable” Confidential to OrganOx Limited : Copyright © OrganOx Limited

Designed by transplant surgeons for transplant surgeons Confidential to OrganOx Limited : Copyright © OrganOx Limited

Issues and trends through the next 5 years Confidential to OrganOx Limited 1.Increased use of organs from elderly donors 2.Increased use of organs from further obese and ECD patients 3.Increasing pressure on transplant surgeons and teams to operate at unsocial hours 4.Greater logistical challenges 5.New technology needs justification 6.Potential for interventions to improve outcomes

Confidential to OrganOx Limited 1.Increased use of organs from elderly donors 2.Increased use of organs from further obese and ECD patients 3.Increasing pressure on transplant surgeons and teams to operate at unsocial hours 4.Greater logistical challenges 5.New technology needs justification 1.Potential for interventions to improve outcomes Issues and trends through the next 5 years

Confidential to OrganOx Limited 1.Increased use of organs from elderly donors 2.Increased use of organs from further obese and ECD patients 3.Increasing pressure on transplant surgeons and teams to operate at unsocial hours 4.Greater logistical challenges 5.New technology needs justification 1.Potential for interventions to improve outcomes

Issues and trends through the next 5 years Confidential to OrganOx Limited 1.Increased use of organs from elderly donors 2.Increased use of organs from further obese and ECD patients 3.Increasing pressure on transplant surgeons and teams to operate at unsocial hours 4.Greater logistical challenges 5.New technology needs justification 1.Potential for interventions to improve outcomes

Issues and trends through the next 5 years Confidential to OrganOx Limited 1.Increased use of organs from elderly donors 2.Increased use of organs from further obese and ECD patients 3.Increasing pressure on transplant surgeons and teams to operate at unsocial hours 4.Greater logistical challenges 5.New technology needs justification 1.Potential for interventions to improve outcomes

Issues and trends through the next 5 years Confidential to OrganOx Limited 1.Increased use of organs from elderly donors 2.Increased use of organs from further obese and ECD patients 3.Increasing pressure on transplant surgeons and teams to operate at unsocial hours 4.Greater logistical challenges 5.New technology needs justification 1.Potential for interventions to improve outcomes

Issues and trends through the next 5 years Confidential to OrganOx Limited 1.Increased use of organs from elderly donors 2.Increased use of organs from further obese and ECD patients 3.Increasing pressure on transplant surgeons and teams to operate at unsocial hours 4.Greater logistical challenges 5.New technology needs justification 1.Potential for interventions to improve outcomes

Summary Confidential to OrganOx Limited 1.Desperate need to increase organ availability 2.Increasing use of marginal organs 3.Need for assessment of organ viability 4.Believe that NMP can make untransplantable organs transplantable  Increases organ availability  Improves patient outcomes and saves lives