Conference on Diabetes Types of diabetes mellitus type 1 -- insulin dependent type 2 – insulin independent Experiment with type 1 genetic or environmental.

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Conference on Diabetes Types of diabetes mellitus type 1 -- insulin dependent type 2 – insulin independent Experiment with type 1 genetic or environmental w/immuno-supp Assay development radioimmunoassay – insulin concentrations histologic evaluation with Bata cell detection blood glucose measurement blood antibodies measurement

ISLETS Of LANGERHANS in pancreas

Acinar cells islet

ISLETS OF LANGERHANS stained with aldehyde-fuchsin, which selectively stains secretory granules of insulin-secreting Beta cells

kidney

Blood sugar concentrations Normal range 80 – 120 mg/dl Diabetic range >120 mg/dl

ROLES AND SPECIFIC ACTIONS OF ANTIOBODIES IN IMMUNITY COMPLEMENT - MEDIATED LYSIS OPSONIZATION - PROMOTE PHAGOCYTOSIS TOXIN NEUTRALIZATION PREVENTION OF MICROBIAL BINDING TO MUCOSAL SURFACE VIRUS NEUTRALIZATION - INTERFERES WITH CELL PENETRATION

EFFECTOR T CELLS DELAYED - TYPE HYPERSENSITIVITY T CELLS CYTOTOXIC CELLS DESTROYS TRANSPLANTED ORGANS

Measure antibodies in blood

radioimmunoassay for insulin blood concentrations

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