ScrMMP-1 Supplementary Fig. 1, Ganguly et al. 0 25 50 75 100 ScrMMP-3 ScrMMP-3MT1-MMP 100 m Relative Invasion 0 25 50 75 100 Scr MMP-1 100 m abc Scr Scr.

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ScrMMP-1 Supplementary Fig. 1, Ganguly et al ScrMMP-3 ScrMMP-3MT1-MMP 100 m Relative Invasion Scr MMP m abc Scr Scr MT1-MMP Relative Invasion MT1-MMP Actin Actin MMP-3 siRNA: Scr MMP Actin MMP siRNA: Scr MMP-1 siRNA: Scr MT1-MMP

Supplementary Fig. 2, Ganguly et al. Relative MMP-1 expression (MMP-1/ -Actin) STI571: - + Actin MMP

GST-CrkGST-STAT3GST GST-STAT3 GST-Crk Abl PP Arg PP Abl PP Arg PP Abl PP IP: GST Supplementary Fig. 3, Ganguly et al. Autophosphorylated c-Abl/Arg GST:

Supplementary Fig. 4, Ganguly et al. Primers: Abl Arg siRNA: Scr Abl Arg Scr Abl Arg Scr Abl Arg Scr Abl Arg Percent of: Scrambled Actin GFP GFP-MMP-1 Abl/Arg Cell Line:

3 H-Thymidine Incorporation (CPM X10 4 ) Supplementary Fig. 5, Ganguly et al. Scr STAT3 a siRNA: Scr Arg Scr Arg pcDNA STAT3C b Cleavage product STI571: pcDNA STAT3C Percent of Untreated: c 49 -actin blot 3 H-Thymidine Incorporation (CPM X10 4 ) Relative PARP Cleavage (PARP/ -actin) STI571: PARP blot pcDNA STAT3C

Supplementary Fig. 6, Ganguly et al. PARP blots STI571: actin blot Treatment/Starvation Time: 48h 96h Cleavage product GAPDH blot 37

Supplementary Fig. 7, Ganguly et al.