Laboratory Investigation advance online publication 8 January 2007; doi:10.1038/labinvest.3700509 No Wnt signaling.

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Presentation transcript:

Laboratory Investigation advance online publication 8 January 2007; doi: /labinvest No Wnt signaling

Laboratory Investigation advance online publication 8 January 2007; doi: /labinvest ß-catenin recruitment and phosphorylation

Laboratory Investigation advance online publication 8 January 2007; doi: /labinvest ß-Trcp binding and ß-catenin degradation

Laboratory Investigation advance online publication 8 January 2007; doi: /labinvest Downstream gene expression inhibited

Laboratory Investigation advance online publication 8 January 2007; doi: /labinvest Wnt signaling

Laboratory Investigation advance online publication 8 January 2007; doi: /labinvest Activation of Disheveled and inhibition of ß-catenin degradation

Laboratory Investigation advance online publication 8 January 2007; doi: /labinvest Formation of LEF/TCF transcriptional complex

Laboratory Investigation advance online publication 8 January 2007; doi: /labinvest Downstream gene expression activated

Laboratory Investigation advance online publication 8 January 2007; doi: /labinvest Crosstalk between Wnts and other pathways