Segmentation outward inward. Three Conformations Myosin-V with ADP (PDB - 1W7I) pre-power stroke state in scallop muscle (PDB - 1QVI) F-actin pre-power.

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Presentation transcript:

Segmentation outward inward

Three Conformations Myosin-V with ADP (PDB - 1W7I) pre-power stroke state in scallop muscle (PDB - 1QVI) F-actin pre-power stroke state in smooth muscle (PDB - 1BR1)

CC= 0.64CC= 0.53 CC= 0.42 CC= 0.58 CC= 0.42 CC= 0.41 outward inward Docking by SITUS (colores) ADP myosin-V Scallop-like pre- power stroke smooth muscle-like pre-power stroke

outward inward ADP myosin-V Scallop-like pre- power stroke smooth muscle-like pre-power stroke Docking by SITUS (colores) CC= 0.64CC= 0.53 CC= 0.42 CC= 0.58 CC= 0.42 CC= 0.41

CC= 0.64 outward Docking by SITUS (myoV-ADP) ADP myosin-V

CC= 0.82 outward Normal Mode Flexible Fitting (myoV-ADP) ADP myosin-V

CC= 0.58 Docking by SITUS (scallop-like) outward Scallop-like pre- power stroke

CC= 0.77 Normal Mode Flexible Fitting (scallop-like) outward Scallop-like pre- power stroke

Fitted scallop-like on F-actin F-actin Myosin-V with ADP (PDB - 1W7I) pre-power stroke state in scallop myosin (PDB - 1QVI) pre-power stroke state in smooth muscle myosin (PDB - 1BR1)