Magnetic Resonance Contributions to Other Sciences Norman F. Ramsey Harvard University Principles of Magnetic Resonance First experiments Extensions to.

Slides:



Advertisements
Similar presentations
Ari Borthakur, PhD Associate Director, Center for Magnetic Resonance & Optical Imaging Department of Radiology Perelman school of Medicine, University.
Advertisements

Relaxation Time Phenomenon & Application
MR TRACKING METHODS Dr. Dan Gamliel, Dept. of Medical Physics,
Functional Magnetic Resonance Imaging Albert Parker February 26, 2002.
Kcal/mol 5.7 X X X X X EIMSNMR.
NMR Spectroscopy.
1 CHAPTER 13 Molecular Structure by Nuclear Magnetic Resonance (NMR)
MRI. Magnetic Resonance 1.Principle first observed in Used for spectroscopy and imaging 3.Imaging techniques are a form of tomography, where slices.
NMR SPECTROSCOPY.
Nuclear Magnetic Resonance Spectroscopy Chemistry 243
Lecture 7. Nuclear Magnetic Resonance (NMR). NMR is a tool that enables the user to make quantitative and structural analyses on compounds in solution.
Structural and Functional Imaging Functional images tend to be lower resolution and fail to convey spatial information Pixels.
Psy 8960, Fall ‘06 Introduction to MRI1 Introduction to MRI: NMR MRI - big picture –Neuroimaging alternatives –Goal: understanding neurall coding Electromagnetic.
Structure Determination by NMR CHY 431 Biological Chemistry Karl D. Bishop, Ph.D. Lecture 1 - Introduction to NMR Lecture 2 - 2D NMR, resonance assignments.
Chem 125 Lecture 63 Preliminary 4/1/08 Projected material This material is for the exclusive use of Chem 125 students at Yale and may not be copied or.
Nuclear Magnetic Resonance Spectrometry Chap 19
Basics of Magnetic Resonance Imaging
A short presentation in the group by Prem Basnet 09/29/04.
Nuclear Magnetic Resonance - NMR results from resonant absorption of electromagnetic energy by a nucleus (mostly protons) changing its spin orientation.
Chapter 19 NMR Spectroscopy. Introduction... Nuclear Magnetic Resonance Spectrometry is based on the measurement of absorption of electromagnetic radiation.
Optically Pumping Nuclear Magnetic Spin M.R.Ross, D.Morris, P.H. Bucksbaum, T. Chupp Physics Department, University of Michigan J. Taylor, N. Gershenfeld.
Psy 8960, Spring ’07 Introduction to MRI1 Introduction to MRI: NMR Physics reminders –Nuclei and atoms –Electromagnetic spectrum and Radio Frequency –Magnets.
Lecture 37 Nuclear magnetic resonance. Nuclear magnetic resonance The use of NMR in chemical research was pioneered by Herbert S. Gutowski of Department.
1 Nuclear Magnetic Resonance Spectroscopy Renee Y. Becker Valencia Community College CHM 2011C.
Quantum Devices (or, How to Build Your Own Quantum Computer)
Nuclear Energy Effects and Uses of Radiation
Determination of Spin-Lattice Relaxation Time using 13C NMR
February 20, 2003Francisco M. Martinez Magnetic Resonance for BME 458 Francisco (Paco) Martinez.
Structure Determination: Nuclear Magnetic Resonance Spectroscopy.
Chapter 3 Nuclear Magnetic Resonance Spectroscopy Many atomic nuclei have the property of nuclear spin. When placed between the poles of a magnet, the.
Week 11 © Pearson Education Ltd 2009 This document may have been altered from the original State that NMR spectroscopy involves interaction of materials.
NMR spectroscopy in solids: A comparison to NMR spectroscopy in liquids Mojca Rangus Mentor: Prof. Dr. Janez Seliger Comentor: Dr. Gregor Mali.
Nmr Spectroscopy Chemistry Objectives u Nmr basics u chemical shifts u relaxation times u 2-Dimensional Nmr experiments u COSY u NOESY u What kind.
Intro to NMR for CHEM 645 we also visited the website: The Basics of NMR by Joseph P. Hornak, Ph.D. The Basics of NMR.
NMR in Medicine and Biology MRI- Magnetic Resonance Imaging (water) In-vivo spectroscopy (metabolites) Solid-state NMR (large structures) Solution NMR.
fMRI Methods Lecture2 – MRI Physics
MC 13.1 Spectroscopy, Pt I 1 Spectrocopy  Nuclear Magnetic Resonance (NMR)spectroscopy  Infrared (IR) Spectroscopy  Ultraviolet-Visible (UV-VIS) Spectroscopy.
NMR in Medicine and Biology
Learning Objectives Use high resolution n.m.r spectrum of simple molecules (carbon, hydrogen & oxygen) to predict The different types of proton present.
NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY Basics of …….. NMR phenomenonNMR phenomenon Chemical shiftChemical shift Spin-spin splittingSpin-spin splitting.
NMR Nuclear Magnetic Resonance By Kurtis Lukey and Matt Loschiavo.
W HAT IS NUCLEAR MAGNETIC RESONANCE ? State that NMR spectroscopy involves interaction of materials with low-energy radio frequency radiation. Describe.
NMR Spectroscopy. NMR NMR uses energy in the radio frequency range. NMR uses energy in the radio frequency range. This energy is too low to cause changes.
13. Structure Determination: Nuclear Magnetic Resonance Spectroscopy
1 Nuclear Magnetic Resonance Nuclear Magnetic Resonance (NMR) Applying Atomic Structure Knowledge to Chemical Analysis.
Magnetic Resonance Imaging – Basic Principles –
Nuclear Magnetic Resonance Spectroscopy. Learning Objectives Use high resolution n.m.r spectrum of simple molecules (carbon, hydrogen & oxygen) to predict.
DEFINTION The study of the interaction between magnetic field of the nuclei and the magnetic component of the electromagnetic radiation(EMR) in the radio.
Lecture 3 16/9/2003 Recall Penning Trap orbits cylindrical coordinates: ( , ,z); B = constant along z radial (  ) and axial (z) electric.
Biomolecular Nuclear Magnetic Resonance Spectroscopy BASIC CONCEPTS OF NMR How does NMR work? Pulse FT NMR 2D NMR experiments nD NMR experiments 01/15/03.
Principles and Applications of NMR Spectroscopy Instructor: Tai-huang Huang (02)
Chapter 13 Nuclear Magnetic Resonance Spectroscopy
Magnetic Resonance Imaging Glenn Pierce, King’s College London, Department of Physics Introduction Edward Purcell and Felix Bloch were both awarded the.
First Principle Calculation of Nuclear Magnetic Resonance (NMR) chemical shift Kanchan Sonkar Center of Biomedical Magnetic Resonance SGPGIMS-Campus, Lucknow,
Structure Elucidation Method
1.Introduction I.Physics of the atomic nucleus 2.A first view on nuclear properties 3.Particle accelerators 4.Particle detection 5.Scattering processes.
Spectroscopy 3: Magnetic Resonance CHAPTER 15. Conventional nuclear magnetic resonance Energies of nuclei in magnetic fields Typical NMR spectrometer.
 This depends on a property of nuclei called spin.  Gyroscope: Principle: As long as its disc remains spinning rapidly the direction of the spin axis.
MOLECULAR STRUCTURE ANALYSIS NMR Spectroscopy VCE Chemistry Unit 3: Chemical Pathways Area of Study 2 – Organic Chemistry.
Biomolecular Nuclear Magnetic Resonance Spectroscopy
Question The bar magnet produces a magnetic field at the compass location Whose strength is comparable to that of the Earth. The needle of the compass.
Nuclear Magnetic Resonance Spectroscopy
Nuclear Magnetic Resonance
Nuclear Magnetic Resonance Spectroscopy
Nuclear Magnetic Resonance (NMR)
Nuclear Magnetic Resonance (NMR) Spectroscopy
Schematic diagram of NMR set-up
Magnetic Resonance Imaging [MRI]
CHY 431 Biological Chemistry
Chapter 19 NMR Spectroscopy.
Presentation transcript:

Magnetic Resonance Contributions to Other Sciences Norman F. Ramsey Harvard University Principles of Magnetic Resonance First experiments Extensions to other fields Summary

MAGNETIC RESONANCE: Electrons and nuclei spin like tops and are magnetized like compass needles. In mag.field B the spin precesses at frequency f 0, Rabi in 1937 proposed add oscillating field at frequency f. Resonance when f=f 0. Detect by change in magnetic state of molecule.

NUCLEAR MAGNETIC MOMENTS: From f 0 : 7 Li and many others.

MAGNETIC INTERACTIONS IN MOLECULES: H 2. First experiments gave no single sharp resonance. Noise. Ph.D. thesis. Lower power. 6 resonances. Due to nucleus interacting with magnetic fields of the other nucleus and the magnetic field of the rotating nuclei. Molecular structure of interest to chemists, such as.

NUCLEAR ELECTRIC INTERACTIONS IN MOLECULES: HD and D 2. Deuteron electric quadrupole moment (deuteron is slightly cigar shaped). Shows there is a previously unsuspected nucleon tensor force in the field of Particle Physics.

ATOMIC HYPERFINE STRUCTURE AND QED: Electron in atom interacts magnetically with nucleus giving rise to a small frequency shift called  hfs. In 1947, it was thought that for atomic H,  hfs could be accurately calculated, but magnetic reson. expts showed theory was wrong, so Schwinger and others developed the theory of relativistic Quantum Electrodynamics (QED).

NMR: In 1946 Purcell, Bloch and others detected magnetic resonance by its effect upon the oscillator making possible magnetic resonance studies on liquids, solids and dense gases. Collision narrowing gave resonances but also also lost much molecular information, but other information could be substituted.

OTHER NMR MOLECULAR INFORMATION: Additional molecular information from chemical shifts in magnetic shielding, from the thermal relaxation time T1 and the phase relaxation time T2 and from the electron coupled spin-spin interaction Ernst and others developed powerful Fourier transform methods for NMR and Hahn developed spin echo techniques for measuring relaxation times. With this information the location of an atom in a molecule can be characterized, making NMR a valuable tool for chemical analysis by chemists, biologists and others. Diseased tissues were studied.

NEUTRON MAGNETIC RESONANCE: With neutron beams similar to atomic beams. With neutrons stored in suitably coated bottles.

ATOMIC CLOCKS: Atomic hyperfine structure  hfs is a natural quantized atomic constant and hence suitable for atomic clock. But need Separated Osc. Fields. Definition of second. Leap second. Contribute to radio astronomy, tests of relativity, GPS, seismology, precision ground, air and space navigation, including air traffic control.

MRI: Although NMR provided valuable information about the materials being studied the observations were not localized in the material. P.C. Lauterbur, P. Mansfield, R.V. Damadian and others developed methods for using inhomogeneous magnetic fields to localize the NMR signals in the sample, leading to the present beautifully detailed magnetic resonance images (MRI)’s and functional (fMRI)’s.

MAGNETIC RESONANCE: Nuclear Magnetic Moments, Molecular Structure, Quantum Field Theory, Particle Physics, QED, Chemical Analysis, Chemistry, Navigation on Earth and in Space, Biology, Time and Frequency, Astronomy, Seismology, Metrology, Tests of Relativity, Medicine, MRI and fMRI.