MMX™ Multi Matrix System Presentation

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Drug Delivery Platform New oral delivery technology Designed for off-patent drugs Focus on inflammatory bowel diseases Scaleable/low cost of goods

The Drug Delivery Platform Multi Matrix System™ (MMX ™) Inert matrix Hydrophilic matrix Gastroprotectant layer LV hydrophilic - amphipatic polymer matrix HV hydrophilic polym. matrix inert matrix material drug (+ excipient)

MMX™ - Release of active ingredient stomach Duodenum Dejunum % Ileum Colon Time

IBD medications: sites of action MMX™ tablets vs. other dosage forms Site of action Oral dosage forms enemas MMX ™ tablets

1h 30’ small intestine 3h 30’ ileum 4h 30’ ascending colon 7h 30’ trasverse colon 10h trasverse colon 15h descending colon

MMX™ 16h descending colon 24h rectum

MMX™ Low absorption after single dose administration in Drug (•) and Metabolite (o)