The Measurable Difference New York City Doctor’s Meeting - June 25, 2004 Presented by Jenny Engemann

LifePak Anti-Aging Formula A comprehensive nutritional wellness program delivering the optimum amounts of all essential and generally beneficial nutrients for long-term health and well-being.

Comprehensive & Convenient > Multi Vitamin Vitamin E 300 IU Calcium & Magnesium Chromium 200 mcg Multi Carotenes Vitamin C 500 mg Multi Flavonoid Better than these 7 popular supplements together.

“… low levels of the antioxidant vitamins (vitamins A, E, and C) may increase risk for several chronic diseases. Most people do not consume an optimal amount of all vitamins by diet alone.” “It appears prudent for all adults to take vitamin supplements.” Journal of the American Medical Association June 2002 Robert H. Fletcher, MD, MSc; Kathleen M. Fairfield, MD, DrPH, Harvard University Journal of the American Medical Association 2002; 287: A Landmark Endorsement

The Need to Supplement

LifePak ® Science is Measurable First to show antioxidant and cardiovascular benefits in double- blind studies 200,000+ published studies on LifePak’s antioxidants Nearly 800,000 published studies on all LifePak ingredients

LifePak 40+ Antioxidants All 8 forms of natural vitamin E: 300 IU Buffered vitamin C: 500 mg Selenium, Copper, Zinc, Manganese 6 Carotenoids: –as found in 5-10 fruits & vegetables per day Over 20 Flavonoids: –6 Catechins, Quercetin, naringenin, hesperidin, 3 Soy isoflavones, Over 10 grape seed polyphenols Alpha-Lipoic Acid: mg

Free Radicals  Highly reactive, short-lived molecules  Damage cells and genetic material (DNA)  70,000 free radical attacks on DNA every day in a cell  Aging process  Implicated in most health conditions  Many different types of free radicals Free Radicals & Antioxidants

Sources of Free Radicals Environmental pollution (smog, ozone, NO 2 ) Radiation exposure: –sunlight (UV-light), X-rays, etc. Smoking: –10,000,000,000,000,000 free radicals/cigarette! Metabolism in your mitochondria

LifePak Health Benefits Optimum supplementation for general well-being 1. Addresses nutrient deficiencies 2. Cardiovascular benefits 3. Complete bone nutrition 4. Promotes healthy immune function 5. Supports blood sugar metabolism 6. Protects against the symptoms of aging 7. Raises your antioxidant defense

LifePak Clinical Study Antioxidant and Cardiovascular Health Smidt CR, Seidehamel RJ, Devaraj S, Jialal I. FASEB Journal Vol.13 No.4, p.A546, March LDL Protection Vitamin E Beta-carotene

LifePak Antioxidant Capacity (ORAC) Jan 2003 Recommended daily antioxidant intake (R. Prior, USDA)

LifePak Support & Resources Which LifePak should I take? –Based on age and gender Complementary products? –MarineOmega Why twice daily? –Bioavailability, antioxidant protection How does X product compare? –LifePak Challenge Where can I find the studies? –US Product Support, pharmanex.com

Pharmanex BioPhotonic Scanner LifePak augments the entire antioxidant defense system The effect can easily be demonstrated using the BioPhotonic Scanner Clinical studies identify link between scores and healthy diet and lifestyle

Pharmanex BioPhotonic Scanner Invented by Werner Gellermann, Ph.D. (U. Utah) Patent rights licensed to Pharmanex Measures carotenoid antioxidants in skin –important group of antioxidants –part of the antioxidant defense system in the body –good indicator of your carotenoid antioxidant status Based on Raman spectroscopy Highly specific for carotenoids Non-invasive and safe Rapid (3 minutes)

What is Raman Spectroscopy? “Raman” effect Intense monochromatic light (one color only) interacts with molecules that have vibrational energy (e.g., carotenoids) and gets scattered at a higher wavelength (color). Sir C. V. Raman, Nobel Prize in Physics, 1930 Carotenoid molecules shift blue laser light color to green: from 473 nm to 510 nm

Is The Scanner Accepted Science? Review paper published in peer-reviewed scientific journal: – Current Topics in Nutraceutical Research, May 2004 – Download at => What’s New link

Scanner Science is Measurable New York Academy of Sciences, Feb 2003 Oxygen Club of California, Feb 2003 and Feb 2004 FASEB/American Society of Nutritional Sciences - April 2003 and April 2004 Gordon Research Conference, Jan 2004 Review paper pending publication in Current Topics in Nutraceutical Research, May 2004

Demographic Study - Sep ,375 Subjects: Results show that Skin Carotenoid Signal: Is not influenced by Age, gender or skin pigmentation (race/ethnicity) Is high in people who eat more fruits & vegetables Is high in people who take LifePak Is low in people who smoke or have oxidative stress (free radical damage)

2004 Data Histogram Mean = 25,406 32,948 Subjects Skin Carotenoid Score Frequency LifePak 5-9 Fruits & Vegetables Average (2-3 Fruits & Vegetables) Smokers Obesity

2004 Data: Fruits & Vegetables

2004 Data: LifePak Usage

Clinical Study - Sep 2002 LifePak  Scanner Score

Body Fat - Inverse Correlation Overweight individuals and anyone on a diet should increase antioxidant protection through diet and supplementation.

Carotenoid Correlation Study June 2003 Smidt CR, Gellermann W, Zidichouski JA; FASEB Journal 18(4) pt.I:A480, 2004

Scan Values in Asians  Singapore study - Dec 2003  Thailand study - Jan 2004  Same data relationship as U.S. study (diet, supplements, body fat, lifestyle)  25,000 average with 82% of participants taking LifePak  LifePak users (2/day) scored 25% higher than non-LP users * Internal data on file

Summary of Scanner Research  Data from 300,000 scans and Asian studies correlate with original demographic study of 1,375 participants  Known risk factors that induce oxidative stress reduce scanner score  Healthy diets improves score  Long-term LifePak supplementation improves score  Score is related to lean body mass & body fat  Desirable scores are in the green/blue zones

Media Coverage in 2003 Self Magazine April 03 Elle Magazine Sep 03 Ms. Fitness Magazine Oct 03 NBC Today in LA KNXV ABC News Phoenix AZ News 3 WHDH-TV NBC Boston MA WHAS 11 News Louisville KY News All Morning New York KUTV News Salt Lake City NewsChannel 4 Columbus OH CNBC Asia - Singapore

The Questions How Does Measuring Skin Carotenoids Predict Antioxidant Status?

Carotenoids Predict Antioxidant Status Recent paper published in the Journal of Nutrition, 2004: – Carotenoids (blood) are indicator of total antioxidant status – Carotenoids interact with the antioxidant network – Vitamin E (blood) is not a good indicator of antioxidant status

VITAMIN C cycle VITAMIN E cycle THIOL cycle NAD(P)H + H + NAD(P) + Lipid–water interface ROOH ROH PUFA O 2 – and other r adicals Metabolism, strenuous exercise, cigarette smoke, pollution ROO RO The Antioxidant Network Carotenoids

The Questions What Does the Scanner Tell Me About My Health? “Low levels of the antioxidant vitamins may increase risk for several chronic diseases.” JAMA, June 2002 Recent Antioxidant Studies † Lycopene reduces risk of heart disease in women Vitamins C, E linked to strong reduction in Alzheimer's risk Multivitamin supplements decrease stroke risk - “SHEEP” study Vitamin C decreases risk of coronary heart disease in women Multivitamin supplements decrease infection and improve quality of life Beta-carotene, vitamin C, selenium associated lower risk of asthma in children † AJCN 2004;79(1): 47-53; J Archives Neurology 2004;61:82-88; J Nutr 2003 Aug;133(8):2650-4; JACC 2003;42(2): ; Ann Intern Med. 2003;138(5):365-71; Am J Resp Crit Care Med 2004;169:

Skin Carotenoid Scores – Example of a person reading 25,000 : – RED – RED: 19,000 and less: Poor diets, no/ineffective supplements, genetic factors, or smoking. – YELLOW – YELLOW: 20, ,000: Better diets and/or supplements. – GREEN – GREEN: 30, ,000: Healthy diets rich in fruits & vegetables and/or good supplements. – BLUE – BLUE: 40,000+: Excellent diets high in fruits & vegetables and excellent supplements.

The Questions What Does “25,000” Mean? Serum equivalent ~1 mcg/ml (±10%, 95% CI) –1,000 units ~0.04 mcg/ml 2-3 fruits/veg./day Average diet

How Can I Improve My Score? Moderate fruit/veg intake Irregular supplement use Smoker High body fat (i.e. smoking) SCS = 20,000

The Questions How Can I Improve My Score? SCS = 42,000 Take LifePak ® 2x/day Improve diet Quit smoking Lose weight (i.e. smoking)

MarineOmega ™ Everyone needs to balance fatty acid intake An excellent source of essential omega-3 fatty acids, EPA and DHA Highest grade fish oils Contains unique krill oil

Essential Fatty Acids Omega-3 –Alpha-Linolenic Acid (LNA) –Eicosapentaenoic Acid (EPA) –Docosahexaenoic Acid (DHA) –Dietary sources: green leafy vegetables, marine oil, flaxseed or canola oil Omega-6 –Linoleic Acid (LA) –Arachidonic Acid (AA) –Dietary sources: sunflower, safflower, corn oil, animal fat, fried food

Why MarineOmega ™ ? Omega-6 Omega-3 Current diets drastically offsets balance (20:1)

Why MarineOmega ™ ? (-10,000 ) Total Fat Saturated Fat n-6 n-3 Humans evolved with optimal ratio of omega-6:omega-3 (1:1)

Fatty Acid Metabolism LNA Omega-3 (Plant) Anti-inflammatory Eicosanoids, 3-PG Triglycerides Cardiac Rhythm Brain Function Omega-3 (Marine) EPADHA 4 % Pro-inflammatory 2-PG LA Omega-6 (Plant) Omega-6 (Animal) AA

Why MarineOmega ™ ? Omega-6Omega-3 MarineOmega™ balances essential fatty acid nutrition

Health Benefits Helps Balance Fatty Acid Nutrition Cardiovascular Health Joint Health Immune Health Skin Health NEW Brain Health Benefits from Krill Phospholipids

Scientific Substantiation Over 100,000 published scientific studies on health benefits of fish and fish oil (Medline )

Krill Oil ( Euphasia pacifica) Unique Features: High in phospholipids (40%) Rich in bioactive EPA and DHA Naturally contains a novel flavonoid and carotenoid antioxidants (astaxanthin) Zooplankton/crustacean from Antartic Ocean Most abundant biomass (<1% harvested)

Krill Oil: High-Activity EPA & DHA Uniquely efficacious EPA and DHA: Highly bioavailable phospholipid form In unique chemical structure for maximum efficacy –cell membranes –cardiovascular function –brain & nerve function Natural “Structured Lipid”

MarineOmega ™ Is Safe Pharmanex ® tests for 60 substances: –Heavy metals (Hg, Cd, Pb, Cr) & As: less than 100 ppb –Pesticides: DDT, DDD, DDE, HCB, Lindane: each less than 50 ppb PCBs less than 90 ppb –25 Dioxins and Furans: less than 2 ppb total –p-Anisidine Value, Acid Value, Iodine Value, Free Fatty Acids, Peroxide Value, Cold Test –Cholesterol (< 4 mg/g) –Complete Fatty Acid Profile –Microbiological Testing

Recommended Usage Recommended for those: –Seeking balance in essential fatty acid nutrition –Desiring additional omega-3 fatty acids in their diet –Taking LifePak ® As a dietary supplement, take two (2) to four (4) softgel capsules daily, with meals

Live Better, Longer ReishiMax TRA Complex IgG Boost CordyMax Cortitrol LifePak Family MarineOmega Optimal Health Free Radical Protection - BioPhotonic Scanner