Myeloid cells matter Conclusions. Glut1+ CD14++ CD16+ Associated with inflammatory markers HIV Immune activation HIV-related diseases Joshua Anzigen:

Slides:

Advertisements

Similar presentations

T follicular helper cells in HIV infection

Advertisements

Purging the HIV-1 Reservoir Through the Disruption of the PD-1 Pathway

HIV-1 virion accumulation and ATP-induced release in human primary monocyte-derived macrophages AIDS Immunopathogenesis Unit Vita-Salute San Raffaele University,

HCV cure: new treatment paradigms for HCV infection Sanjay Bhagani Consultant Physician/Senior Lecturer Royal Free Hospital/UCL London.

Pag. Tran Thi Thanh Huyen – Vrije Universiteit Brussel - Belgium Washington, D.C., USA, July 2012 Monocytes and the Complement System in TB-IRIS.

Immune Response to HIV Infection June 28, 2001 Ms. Jane Coyle-Morris Wyeth-Ayerst Research.

Controversies in HIV Cure Research Debate 1. Is there ongoing replication under HAART? Mario Stevenson and Frank Maldarelli Moderator: Steve Deeks.

Myeloid dendritic cells and HIV latency in resting T-cells Nitasha A Kumar, Vanessa A Evans, Suha Saleh, Candida de Fonseca Pereira, Paula Ellenberg, Paul.

T cells Jan Novák. The immune system Protection against infectious agents Clearance of dying, damaged and dangerous cells Regulation of the immune responses.

Hedlund S, et al. (2010) Dendritic cell activation by sensing Mycobacterium tuberculosis–induced apoptotic neutrophils via DC-SIGN, Hum Immunol, doi: /j.humimm

Immune Reconstitution Inflammatory Syndrome (IRIS)

TB and HIV Coinfection Bruce A. Bush, M.D.

Cell- and Tissue-based Measures of Viral Persistence Are Associated with Immune Activation and PD-1-Expressing CD4+ T cells H Hatano 1, V Jain 1, PW Hunt.

VIRUSES. Lytic vs. Lysogenic Vaccines First made was in 1700’s- fight smallpox Help prevent viral infections, but they cannot cure most viral infection.

Rémi Cheynier Victor Appay Anne Hosmalin Gianfranco Pancino Vincent Vieillard Brigitte Autran Françoise Brun-Vezinet Charlotte Charpentier Diane Descamps.

The Body’s Defenses Chapter 43.

Human M. tuberculosis infection/ disease: classical pathology and immunology (Slide -1) W. Henry Boom, M.D. Tuberculosis Research Unit (TBRU) Case Western.

Cell-specific type I Interferon signatures in autoimmunity and viral infection: what makes the difference? Chieko Kyogoku 1, Biljana Smiljanovic 1, Joachim.

KEY CONCEPT Some viral diseases can be prevented with vaccines.

Jehona Latifi Biochemistry 658. The Immune System  Innate Immunity Antigen-nonspecific defense system Examples: skin, stomach acid, mucus, etc.  Acquired.

The Potential of Attenuated Mycobacterium tuberculosis or BCG Vaccines to Enhance Oral SIV Acquisition in Infant Macaques IAS Meeting-Vancouver July 22,

Neonatal Immunology Kristina Abel, PhD CNPRC UC Davis How a Lymphomaniac views ( IL )lness.

Crohn’s Disease & Mycobacterial Infections Kimberly Persley, MD October 19, 2005.

Myeloid dendritic cells induce HIV-1 latency in non- proliferating CD4 + T cells IAS WORKSHOP, 16 & 17 JULY 2010.

HIV-1 infection decreases CD127 and PD1 expression on duodenal CD8+T cells Liliana Belmonte, PhD Academia Nacional de Medicina Buenos Aires, Argentina.

MICR 304 Immunology & Serology Lecture 6 NK Cells, Lymphocytes Chapter 1.4 –1.17; 2.30 – 2.33 Lecture 6 NK Cells, Lymphocytes Chapter 1.4 –1.17; 2.30 –

___________DEFENSES of the HOST: THE IMMUNE RESPONSE

The Future of HIV/AIDS: The Road to a Cure. How HIV persists during therapy?  Ongoing viral replication occurs in subjects on suppressive HAART (TW Chun,

PHL 633 Immunotoxicology First and second Lectures By Abdelkader Ashour, Ph.D. Phone:

ORGANIZATION OF THE IMMUNE SYSTEM different cell types diffuse communication network between cells ‚signal transduction’ and inhibition similarity to the.

White blood cells and their disorders Dr K Hampton Haematologist Royal Hallamshire Hospital.

Human Immunodeficiency Virus (HIV) & Acquired Immune Deficiency Syndrome (AIDS) Prepared by: Dr.Amany Ballow Consultant Immunology.

Monocytes in Immune Defense & Cell-mediated Cytotoxicity Pin Ling ( 凌斌 ), Ph.D. ext 5632; References: 1. Male D., J. Brostoff,

Interferons Induction of synthesis Induction of antiviral activity Antiviral activities induced by interferons  and  Antiviral activities induced by.

MYCOBACTERIA Dr.Qurat-Ul-Ain Senior Demonstrator Microbiology, KEMU, Lahore.

The Dynamics of HIV RNA, CD4+ Count and Mycobacterium tuberculosis (Mtb) Antigen Specific Cytokines in TB/HIV Patients Following Successful Tuberculosis.

What’s All the Fuss About the Microbiome?

Immunology Essentials Introduction to Innate and Adaptive Immunity

Inflamm Intest Dis 2016;1: DOI: /

Chronic immune activation in HIV associated Non Hodgkin lymphoma and the effect of antiretroviral therapy Brian Flepisi University of the Western Cape.

Mononuclear phagocytes in Immune Defence

Pathogenesis of viral infection

Anifrolumab inhibits cytokine production, plasmacytoid dendritic cell (pDC) activation and the type I (interferon gene signature) IFN gene signature. Anifrolumab.

Figure 1 Role of innate lymphoid cells (ILCs) in steady state,

Ch 43 The Body’s Defense.

KEY CONCEPT Some viral diseases can be prevented with vaccines.

Innate Immunity.

Introduction. Looking Beyond HIV Infection: CCR5 Blockade as an Immunomodulatory Concept

by JoAnn Castelli, Elaine K

by Venetia Bigley, Laura E. Spence, and Matthew Collin

Monocyte gene expression differentiates cases of TB-IRIS from controls both before and shortly after initiation of ART Tran Thi Thanh Huyen Kuala Lumpur,

Figure 2 Systemic immune responses to cryptococcal antigen

Nat. Rev. Nephrol. doi: /nrneph

O. Turriziani, M. Andreoni, G. Antonelli

Interaction of hypercholesterolemia and inflammation in atherogenesis

Figure 4 Cascade system activation on a biomaterial surface

Correlation between disease activity and phospho-H2AX levels at G0/G1, S and G2 cell-cycle phases in primary CD3+ T cells and monocytes from patients with.

Immunity to infectious agents

Host Immune Response to Infection and Cancer: Unexpected Commonalities

Postoperative changes in blood monocyte subsets.

Monocyte-Macrophages and T Cells in Atherosclerosis

Immune reconstitution inflammatory syndrome (IRIS) associated with Mycobacterium tuberculosis (TB) infection. a) In healthy individuals in response to.

KEY CONCEPT Some viral diseases can be prevented with vaccines.

Diclofenac treatment reduces L-selectin on peripheral blood and infiltrated leukocytes but does not alter accumulation in the injured spinal cord. Diclofenac.

Immune cell populations associated with type I IFNGS test status and disease activity. Immune cell populations associated with type I IFNGS test status.

KEY CONCEPT Some viral diseases can be prevented with vaccines.

KEY CONCEPT Some viral diseases can be prevented with vaccines.

Overall gene expression in monocyte subsets in patients and controls.

Early events following Orientia tsutsugamushi infection.

HBeAg seroconversion is associated with a more effective PD-L1 blockade during chronic hepatitis B infection Sara Ferrando-Martinez, Kelly Huang, Angie.

Presentation transcript:

Myeloid cells matter Conclusions

Glut1+ CD14++ CD16+ Associated with inflammatory markers HIV Immune activation HIV-related diseases Joshua Anzigen: Intermediate monocytes are possible markers to identify HIV- infected subjects at risk for HIV-1 related co-morbidities

Francesca Graziano : Purging the HIV reservoir ? ATP stimulation of Mφ Adapted from M. Stevenson, Nat Med ATP HAART Extracellular virion release Intracellular virions accumulation

Maria Isabel Sade-Ovalle : Tim3-Gal9 T cell-Mφ interaction Favor HIV entry Favor HIV- specific T cell responses Blocking antibodies modulation of cytokines release from T cells and Mφ Control of M.tb. growth in HIV patients ? Modulation of the Tim3-Gal9 pathway favor antimicrobial immunity against Mycobacterium tuberculosis

Tran Huyen: In TB – HIV coinfection Alteration of pro/anti inflammatory genes and modulation of the complement system in monocytes Identify specific signatures prognostic for development of TB-IRIS Monocytes contribute to the development of TB-IRIS

Dysregulation of Metabolic pathways Non-communicable diseases Reservoir of HIV HIV-related dementia Opportunistic infections IRIS Myeloid cells matter

Points for discussion Immune activation drives disease progression. Classical (CD14+CD16-) vs non classical (CD14+/CD16+) monocytes: what is their role in immune activation? Increased level of blood non classical monocytes is correlated with disease progression. Non classical M-DC8+ monocytes accumulate in the peripheral blood of viremic untreated patients (Dutertre et al. 2013). Better definition of monocyte/macrophages and DC subsets in several anatomical compartment…and their role as viral reservoirs. Focus on alternative approaches to purge HIV reservoirs.