William S. Klug Michael R. Cummings Charlotte A. Spencer Concepts of Genetics Eighth Edition Chapter 18 Cell Cycle Regulation and Cancer Copyright © 2006 Pearson Prentice Hall, Inc.

Cancer Is a Genetic Disease About 1% are associated with germline mutations

Figure 18-1a Copyright © 2006 Pearson Prentice Hall, Inc.

Figure 18-1b Copyright © 2006 Pearson Prentice Hall, Inc.

Cancer Is a Genetic Disease What Is Cancer? The Clonal Origin of Cancer Cells Cancer As a Multistep Process, Requiring Multiple Mutations

Figure 18-2 Copyright © 2006 Pearson Prentice Hall, Inc.

Figure 18-3 Copyright © 2006 Pearson Prentice Hall, Inc. Cancers often develop in progressive steps

Cancer Cells Contain Genetic Defects Affecting Genomic Stability and DNA Repair Link: Aneuploidy can cause cancer

Figure 18-4a Copyright © 2006 Pearson Prentice Hall, Inc.

Figure 18-4b Copyright © 2006 Pearson Prentice Hall, Inc. Homogeneous

Figure 18-5 Copyright © 2006 Pearson Prentice Hall, Inc.

Gleevec

Tomlins et al.

Figure 18-6 Copyright © 2006 Pearson Prentice Hall, Inc. HNPCC (hereditary nonpolyposis colorectal cancer) Pedigree – defects in mismatch repair

Cancer Cells Contain Genetic Defects Affecting Cell Cycle Regulation The Cell Cycle and Signal Transduction Cell Cycle Control and Checkpoints

Figure 18-7 Copyright © 2006 Pearson Prentice Hall, Inc.

Figure 18-8 Copyright © 2006 Pearson Prentice Hall, Inc.

Figure 18-9 Copyright © 2006 Pearson Prentice Hall, Inc.

Figure Copyright © 2006 Pearson Prentice Hall, Inc. Apoptosis may occur if damage is severe

Many Cancer-Causing Genes Disrupt Control of the Cell Cycle

Table 18-2 Copyright © 2006 Pearson Prentice Hall, Inc.

Figure Copyright © 2006 Pearson Prentice Hall, Inc. Ras proto-oncogenes

Figure Copyright © 2006 Pearson Prentice Hall, Inc.

Figure Copyright © 2006 Pearson Prentice Hall, Inc.

The p53 Tumor Suppressor Gene (the “guardian of the genome”)

Figure Copyright © 2006 Pearson Prentice Hall, Inc.

The RB1 Tumor Suppressor Gene

Figure Copyright © 2006 Pearson Prentice Hall, Inc.

Figure Copyright © 2006 Pearson Prentice Hall, Inc.

from Arnold et al. (2005), Cancer 104: Epigentic gene silencing can play a role in cancer

Cancer Is a Genetic Disorder Affecting Cell–Cell Contact

Figure Copyright © 2006 Pearson Prentice Hall, Inc.

Predisposition to Some Cancers Can Be Inherited

Table 18-3 Copyright © 2006 Pearson Prentice Hall, Inc.

Figure Copyright © 2006 Pearson Prentice Hall, Inc.

Figure Copyright © 2006 Pearson Prentice Hall, Inc.

Viruses Contribute to Cancer in Both Humans and Animals

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Table 18-4 Copyright © 2006 Pearson Prentice Hall, Inc.

Table 18-5 Copyright © 2006 Pearson Prentice Hall, Inc. New idea about viruses and cancer Research article, Zhao et al 2007 Links:

Cervical Cancer Vaccine Gets Injected With a Social Issue Some Fear a Shot For Teens Could Encourage Sex By Rob Stein Washington Post Staff Writer Monday, October 31, 2005; Page A03 Vaccine Prevents Most Cervical Cancer Published: October 7, Link:

NYTimes article on new teatment Link:

Environmental Agents Contribute to Human Cancers