Regenerative Medicine Society 13/05/2015 Preventative Medicine, Biotech & Bioinformatics Combat Degenerative Diseases

Introduction What is the aim of the group  Advocate Regenerative/Preventative Bio-medical Therapies from Ireland  Encourage Research and Development in Preventative Medicine and Cures to Combatting Age related and other degenerative diseases  Public Education/Awareness of advancements in these areas of medicine/technology

Introduction Who we are:  Brian Collins - Former Biotech Engineer/Analyst Founder of Regenerative Medicine Society Founder of Preventative Med & Biotechnology Group  Barbara Cottier – Assistant & Administrator

Introduction  Recent Developments  Google Calico (September 2013)  Longevity Inc (February 2014)  In Silico Medicine (March 2014)  Large Scale Corporate Development

Main Affiliations  SENS (Strategies for Engineered Senescence)

Known Aging Mechanisms – SENS Aging Model Please note this list is not necessarily exhaustive

SENS Affiliations  Some Leading Universities collaborating with SENS:  Harvard - George Church – Gene Therapy and Cancer  MIT-Robert Langer-Biomaterials, Stem Cells  YALE - David Spiegel –Cardiovascular/Skin/Muscular Aging  RICE University - Pedro Alvarez - Cellular Damage  Cambridge-Mark Kotter- Stem Cell and Gene Delivery  Moscow State University-Vladimir Sculachev – Mitocondrial Therapy  Marie Curie University Paris - Marisol Corral-Debrinski - Mitocondria  University of Tobingen - Graham Pawelec - Immunotherapy

Interested Therapies & Technologies  Stem Cell Therapy and Organ/Tissue Growth  Gene Therapy  Immunotherapy and Immunosuppressants  Biomaterials  Molecular Enzyme and Hormone Therapy  Proteomoic/Protein Expressions  Nanotechnology  Electronic Medical Diagnostics-Preventative diagnostics  Bio Informatic  General Preventative Medicine

Topic This Evening: Epigenetics & Epigenetic Therapeutics Science/Technologies: (epi)Genetics & interactions Gene & RNA Sequencing RNA interfacing Micro RNA Neurogenomics Epidrugs & Epitherapeutics

Recent Breakthroughs  Role of Epigenetics on health, psychology, aging, gender & memory/intelligence  Epigenetic cross generation influence  Epigenetic interfacing, use of transcription factors & micro RNAs  Development of RNA sequencing and epigenome  Application of epidrugs & epigenetic therapeutics for cancer

Videos for the Evening  Introduction to Epigenetics: Epigenetics Overview:  Sens Confereence, Epigenetics & Agings Aging, Epigenetics & Blood Swap Epigenetics Cross generation Influence: Epigenetic Therapies for Cancer:

Recommended Resources More Information about SENS, Aging & Biology : Brain Gender: than-originally-thought-research-reveals Reverese aging by altering genetic expression: psychiatry/blood-revival-young-mice-reverse-aging-old Epigenetics & Depression: depression/ Epigenetics & Neural Plasticity/Memory:

Support Research in Ireland  Fundraise relevant research in Ireland  Provide platform for collaboration with our international colleagues

Raise Public Awareness  Educational Initiatives  Press Relations  Documentaries  National Education Petitions  Webcasts  Regular Guest Speakers  Possible Publishing of New Book about development in this area of Medicine (for Lay readers)

PM/Regenerative Med Society Platform  Meetups monthly (Parallel: Activity and Social Meetups)  Social Media and Websites for information and activities to support this cause  People required with Science (Biology, Medicine, Informatics/Programming, Engineering, Physics),  Advertising/Event Promotion and people from all backgrounds actively welcomed

What to Do Now  Sign up on Facebook, Meetup, and website (when functional)  Invite ten others to join on Facebook  Read up on relevant developments on Facebook and Website  Invite interested friends to next Meetup  Help distribute future /facebook petitions

Q & A

Suggestions

Why are we doing this? FUN! NOT FUN!