Polypetides and proteins

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Polypetides and proteins L.O.: Explain the formation of a peptide (amide) linkage between α-amino acids to form polypeptides and proteins. Describe the acid and alkaline hydrolysis of proteins and peptides to form α-amino acids or carboxylates. Exam qs

Formation of a dipeptide between glycine and alanine Peptide: compound containing amino acids linked by peptide bonds. Peptide bond: amide bond in proteins and peptides.

Formation of a dipeptide between glycine and alanine Draw an alternative dipeptide made from the condensation of glycine and Alanine.

Alternative reaction of alanine and glycine 4

Section of a polypeptide showing four different amino acids 5

Acid hydrolysis of a dipeptide Reaction conditions: reflux with HCl for 24 hours. 6

Alkaline hydrolysis of a polypeptide chain Reaction condition: NaOH, heat Note: sodium salts are formed. 7

Peptide hydrolysis (powerPoint)

Draw the organic products formed when the following protein is heated with concentrated hydrochloric acid:

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