FNA of breast Slide session The 6th Arab-British School of Pathology

Slides:



Advertisements
Similar presentations
Atypical ductal hyperplasia “A diagnosis of ADH should not be made unless a diagnosis of low grade DCIS is being seriously considered” WHO Breast 2012.
Advertisements

Interventional Radiology : Useful for All and Always ?
DISEASES OF THE BREAST IN ACCRA Solomon E. Quayson MSc(Lond).,DIC.,FWACP.
Breast Cancer. Introduction Most common female cancer Accounts for 32% of all female cancer 211,300 new cases yearly and rising 40,000 deaths yearly.
FNA of BREAST The 6th Arab-British School of Pathology
July 21, year old female. Thin prep pap A) Reactive endocervical cells B) HSIL C) LSIL D) Squamous metaplasia E) ASCUS 1.
Histopathology and Cytology for Breast lesions Britt-Marie Ljung MD Professor of Pathology, Dir. of Cytology University of California at San Francisco.
Connie Lee, M.D. UF Surgery
Breast Pathology Helge Stalsberg MD University Hospital of North Norway.
Week of March 30, year old female. Conventional pap A.Endocervical adenocarcinoma in situ B.Benign endometrial cells C.Viral changes consistent.
Slide Seminar Sami Shousha, MD, FRCPath Department of Histopathology, Charing Cross Hospital & Imperial College, London Amman, November 2013.
Histopathology and staging of breast cancer
MCQs On Breast Imaging:
Malignant Adenomyoepithelioma of the Breast with Lymph Node Metastasis
Breast Dr. Raid Jastania.
Pathobiology of Breast Cancer Associate Professor Department of Pathology and Laboratory Medicine Ruth A. Lininger, MD MPH.
Minimally Invasive Follicular Carcinoma: A Cytological and Histological Challenge David Poller, Queen Alexandra Hospital,Portsmouth, UK.
Procedures used by CHTN
Breast Pathology Dr. M. Griffin.
Breast.
DISEASES OF THE BREAST.
1 Breast MP/H Task Force Multiple Primary Rules Histology Coding Rules 2007.
Benign and Malignant Lesions in Respiratory Cytology
Proliferative Epithelial lesions of the Breast
Dr. Malcolm Hayes BC Cancer Agency Vancouver, Canada
Breast Pathology Seminar CASE PRESENTATION PART 1 Elba Torres Matundan MD FCAP Victor Carlo Vargas MD FCAP.
Morphology of breast cancer
Breast disease Dr. A. Basu MD.
Clinico-Pathological Conference (CPC) Meet Karpagam Medical College Hospital
Neoplasia I Walter C. Bell, M.D..
SYB 1 Erin Gundersen MS IV. Breast Cancer Breast Cancer.
DS Ross,1 DD Giri,1 MM Akram,1 JP Catalano,1
Breast Pathology. Breast pathology Inflammatory Disorders Acute Mastitis Preiductal Mastitis Mammary Duct Ectasia Fat Necrosis Lymphocytic Mastopathy.
The Breast. Acute mastitis S. aureus Breastfeeding Fever, erythema, pain Periductal mastitis – subareolar mass, smoking, keratinizing Periductal mastitis.
Session 5. Case Diagnosis - Sclerosing adenosis with lobular neoplasia. No invasion in images provided.
Session 4. Biopsies. Professor Sarah Pinder. Case A - SP
IN THE NAME OF GOD FIN GARDEN KASHAN. FNA of the Parotid gland In a 22 y/o woman Case 1:
Outline Intraductal proliferative lesions
Faculty of Allied Medical Sciences Histopathology and Cytology (MLHC-201)
Imaging examinations of breasts
Changes in Breast Cancer Reports After Second Opinion Dr. Vicente Marco Department of Pathology Hospital Quiron Barcelona. Spain.
Breast Pathology Emad Raddaoui, MD, FCAP, FASC
Breast disease MUDr. Petr Šafář, CSc.. Anatomy of female breast.
Neoplasia p.1 SYLLABUS: RBP(Robbins Basic Pathology) Chapter: Neoplasia Definitions Nomenclature Characteristics of benign and malignant neoplasms Epidemiology.
Diagnostic Challenge Pathology for Neurosurgery & Neurology Residents Department of Pathology University of Oklahoma Health Sciences Center, Oklahoma City,
Week of September 29, year old female. ThinPrep pap A.Lactobacillus B.Gonorrhea C.Trichomonas D.Bacterial Vaginosis E.Artifact 1.
每月一例 2015 February 40 y/o, female Breast FNA Liquid-Based Preparation (SurePath) Figure 1-6.
Breast Tumors Diagnosed as Papillary Neoplasm by FNAB Dae-Kyum Kim, Sang-Uk Woo, Jeong-Han Kim, Seok-Jin Nam, Yoon-La Choi 1, Young-Lyun Oh 1 and Jung-Hyun.
NEOPLASIA CASES. CASE 1 A 20 year old female presented with a round mobile breast lump. She has no family history of breast cancer Question : What test.
March 13, y/o female. FNA of thyroid. 1 Hashimoto’s thyroiditis Lymphocytes mixed with follicular cells.
Educational case 1 Dr JD Hemming Queen Elizabeth Hospital Gateshead.
Cytopathology Feb Cytopathology at cellular level Study of pathological changes at cellular level. fluid or free cells Samples are fluid or.
Lesions of female breast are much more common than lesions of male breast Most of these lesions are benign Breast cancer is 2 nd most common cause of.
BREASTTUMORS Ch. 18 p (704 – 713). LYMPHATIC DRAINAGE AXILLARY (MOSTLY) INTERNAL MAMMARY SUPRACLAVICULAR.
KCP-786 KCP-786 서울대학교 병원 전공의 백해운. History 59 세 (Gravida5, Para2) 2007 년 HPV18(+) 이후 자궁질 도말검사를 수 차례 받음 Op Hx : 2011 년 담낭결석, 2010 년 복압 요실금 기타 특이사항 없음 2012.
KCP792 79/ 여자, 자궁경부 / 흉수 성균관의대 병리학교실 강북삼성병원 병리과 채승완.
KCP 778 토의자 가천대 길병원 R3 강명희 2013 년 4 월 5 일 세포병리학회 월례집담회.
Dr Nandini N.M Prof, Dept of Pathology
KCP-815 서울대학교 병원 전공의 최은오.
KCP 794 인하대병원 전공의 최창환.
Fine-needle aspiration of clinically suspicious palpable breast masses with histopathologic correlation Reshma Ariga, M.D., Kenneth Bloom, M.D., Vijaya.
Ductal Carcinoma In situ of the Male Breast
Columnar cell lesions and atypical ductal hyperplasia
Invasive breast cancer. A
Finger like projections, lined by several layers of benign looking squamous cells , with central fibrovascular core Diagnosis: squamous cell papilloma.
Finger like projections,, with central fibrovascular core covered by several layers of benign looking squamous cells Diagnosis: squamous cell papilloma.
Acta Cytologica 2014;58: DOI: /
FNAC for Diagnosis - the very basic for ALL –
Peter Kulesza, Isam A. Eltoum  Clinical Gastroenterology and Hepatology 
(A–C) Electron microscopic images obtained from two different cases, (A) a cluster of large malignant cells with cytoplasmic mucin vacuoles consistent.
Presentation transcript:

FNA of breast Slide session The 6th Arab-British School of Pathology Nina S Shabb AUBMC

Fibroepithelial lesions Cases 1-3 Fibroadenoma 3 components Phyllodes tumor vs FA Older women Larger/cystic Adequate sampling Cellular stromal fragments Cytologic atypia/mitosis (malignant) Epithelial discohesion and atypia? Adenocarcinoma arising in FA PT misdiagnosed as adenocarcinoma (proper preparation)

Fibroadenoma Most common cause of false positive dx Cellular smear, may find single cells with atypia and discohesion Do not spend too much time on high power looking for discohesive single cells. Helpful feature: Numerous ME cells Do not call malignant with numerous ME cells in background

Final dx Case 1: Case 2: Case 3: FNA dx: Cellular FA vs Benign PT. Final dx: FA Case 2: Final dx: PT Case 3: PT/C4 (low grade carcinoma)

Ductal adenocarcinoma NOS Cases 4 and 5 Cytologic features? Tumor cellularity Discohesion Single cells with features of malignancy Grading Nuclear grade 1-3

Final dx Case 4: Case 5 FNA dx: Adenoca NG 2/3 Final DX: Adenoca nos Grade 2/3 Case 5 FNA dx: Adenoca NG 1/3 Final DX: Adenoca nos Grade 1/3

Mucinous/colloid carcinoma Cases 6 and 7 Gross can mimic benign disease. Mucin seen grossly while aspirating and smearing Extracellular mucin on pap and DQ Round balls of low grade tumor cells If pure mucinous, has better prognosis but FNA can not determine that. FNA: Suggestive of mucinous ca

Lobular carcinoma Case 8 and 9 What are the FNA features of classic lobular carcinoma?

Case 8 Classic lobular carcinoma

Case 9 Pleomorphic lobular ca Intraductal papilloma How do we deal with papillary lesions on FNA?

Tubular ca Case 10 Angular, rigid, bent tubular clusters, sharp borders Crowded nuclei Minimal tumor discohesion Dispersed single cells, minimal atypia Absence/paucity of ME cells Peripheral perpendicular cells

FNA of axillary LN Case 11 Metastatic adenocarcinoma c/w breast primary False negative? Other malignancy?

FNA of DCIS Case 12 DCIS Grade 3: DCIS cribriform DCIS grades 1 and 2: Pleomorphic carcinoma cells, calcium, necrosis, macrophages casting Calcification on mammogram DCIS cribriform Low grade carcinoma punched out holes in cell clusters DCIS grades 1 and 2: No distinguishing features