Test of the proposed method Introduction CCD Controller CCD Illuminator gel Filter 585nm Assembling the phantom before its irradiation. The phantom, ready.

Slides:



Advertisements
Similar presentations
Giorgio Russo National Research Council, Institute of Bioimaging and Molecular Imaging (IBFM) Fondazione Istituto San Raffaele G. Giglio di Cefalù Istituto.
Advertisements

F. Foppiano, M.G. Pia, M. Piergentili Medical Linac IEEE NSS, October 2004, Rome, Italy
The Vin č a Institute of Nuclear Sciences, Belgrade, Serbia * Universita degli studi di Bologna, DIENCA, Italia Radovan D. Ili}, Milan Pe{i}, Radojko Pavlovi}
14th GEANT4 User and Collaboration Workshop - Catania, Oct. 15/ B.Caccia, G.Frustagli, M.Mattia, S.Valentini Istituto Superiore di Sanita' e INFN,
RapidArc plan verification using ArcCHECK™
Energy deposition and neutron background studies for a low energy proton therapy facility Roxana Rata*, Roger Barlow* * International Institute for Accelerator.
Fricke gel dosimeters for the measurement of the anisotropy function of a HDR Ir-192 brachytherapy source Mauro Carrara 1, Stefano Tomatis 1, Giancarlo.
P. Pérez, V. Galván, G. Castellano & M. Valente.  To develop a simple and versatile dosimetric method capable of determining changes in matter (Xylenol.
Lic. Pedro Antonio Pérez.  To develop a simple and versatile dosimetric method capable of determining changes in matter (Xylenol Orange added Fricke.
Introduction A Fricke gel was the first dosimetric system to offer the possibility of making 3-D radiation dose measurements in a totally non-destructive.
Introduction Three-dimensional gel dosimetry is a novel method for radiation measurement motivated by the need to verify experimentally the doses produced.
Tissue inhomogeneities in Monte Carlo treatment planning for proton therapy L. Beaulieu 1, M. Bazalova 2,3, C. Furstoss 4, F. Verhaegen 2,5 (1) Centre.
Introduction The effect of air-cavities within the human body, for example in the head and neck regions, present possible sources of error when calculating.
At the position d max of maximum energy loss of radiation, the number of secondary ionizations products peaks which in turn maximizes the dose at that.
The brachytherapy advanced example Susanna Guatelli (CERN/INFN)
11. – , Athens 8th European Conference on Medical Physics DOSIMETRY AUDITS IN RADIOTHERAPY IN THE CZECH REPUBLIC Irena Koniarová Daniela Ekendahl.
Michele Togno ARDENT ESR 11 – 2D Ionization Chambers Array for Clinical Applications Michele Togno – ARDENT midterm review preparatory meeting, CERNJune,
Quality Control in Radiation Therapy, A New Concept: Dosimetry Check
Introduction A modification of the Fricke solution system to make it suitable for low-level dosimetric studies was proposed about three decades ago [1].
TÍTULO DO TRABALHO NOMES DOS AUTORES ENDEREÇOS E DOS AUTORES INTRODUTION Gammacell 220 Series 39 is a irradiation device purchased by CDTN/CNEN in.
Evaluation of the Performance of the Fast Scanning Platform of an OCT System Malcolm Heard 1, Miguel Herrera 1, Geoffrey Ibbott 1 1 Department of Radiation.
1 GEANT4: Applications in Medical Physics B. Caccia Department of Technology and Health Istituto Superiore di Sanità (Italian National Institute of Health)
In vivo dosimetry Eirik Malinen Eva Stabell Bergstrand Dag Rune Olsen.
16 th International Congress on Neutron Capture Therapy June 14-19, 2014 Helsinki, Finland Study of suitability of Fricke-gel-layer dosimeters for in-air.
G. Bartesaghi, 11° ICATPP, Como, 5-9 October 2009 MONTE CARLO SIMULATIONS ON NEUTRON TRANSPORT AND ABSORBED DOSE IN TISSUE-EQUIVALENT PHANTOMS EXPOSED.
Surface dose prediction and verification for IMRT plans using line dose profiles † Ronald E. Berg, † Michael S. Gossman and ‡ Stephen J. Klash † Erlanger.
F. Foppiano, B. Mascialino, M. G. Pia, M. Piergentili Geant4 Simulation of an Accelerator Head for Intensity Modulated RadioTherapy Monte Carlo 2005 Topical.
S Optical CT scanning of PRESAGE TM polyurethane samples with a CCD-based readout system S J Doran 1*, N Krstajic 1, J Adamovics 2 and P M Jenneson 1 1.
Application of a 2-D ionization chamber array for dose verification of dynamic IMRT with a micro-MLC Fujio ARAKI, PhD 1, S. TAJIRI 2, H. TOMINAGA 2, K.
A General Purpose Brachytherapy Software Simulation + Analysis (isodose calculation) 2/10/2002 Geant4 Workshop CERN Susanna Guatelli Univ. and INFN Genova.
Medical Accelerator F. Foppiano, M.G. Pia, M. Piergentili
Fig. 3 shows how a dose distribution that is initially relatively sharp becomes blurred with time, until after 16 hours, virtually no useful information.
Araki F. Ikegami T. and Ishidoya T.
Investigation of 3D Dosimetry for an Anthropomorphic Spine Phantom R. Grant 1,2, G. Ibbott 1, J. Yang 1, J. Adamovics 3, D Followill 1 (1)M.D. Anderson.
High resolution X-ray analysis of a proximal human femur with synchrotron radiation and an innovative linear detector M.Bettuzzi, R. Brancaccio, F.Casali,
Congresso del Dipartimento di Fisica Highlights in Physics –14 October 2005, Dipartimento di Fisica, Università di Milano An application of the.
Spectral Image Analysis of a natural color sample using Rewritable Transparent Broad-band Filters Kanae Miyazawa (1), Markku Hauta-Kasari (2), and Satoru.
IRCC & Mauriziano Hospital & INFN & S Croce e Carle Hospital
Introduction The Radiological Physics Center (RPC) anthropomorphic quality assurance (QA) phantom program is one tool the RPC uses to remotely audit institutions.
Conclusions Despite being able to acquire successfully high resolution images of radiation dose, image quality is limited by hardware problems. Upgrading.
F. Foppiano, M.G. Pia, M. Piergentili
P. Rodrigues, A. Trindade, L.Peralta, J. Varela GEANT4 Medical Applications at LIP GEANT4 Workshop, September – 4 October LIP – Lisbon.
Optimization of Volumetric Modulated Arc Therapy (VMAT) Planning Strategy Using Ring-shaped ROI for Localized Prostate cancer Kentaro Ishii, Masako Hosono,
TLD POSTAL DOSE QUALITY AUDIT FOR 6MV AND 15MV PHOTON BEAMS IN RADIOTHERAPY CLINICAL PRACTICE Sonja Petkovska 1, Margarita Ginovska 2, Hristina Spasevska.
Metal micro-detector TimePix imaging synchrotron radiation beams at the ESRF Bio-Medical Beamline ID17 Andrii Chaus Institute for Nuclear Research National.
Implementation of a New Monte Carlo Simulation Tool for the Development of a Proton Therapy Beam Line and Verification of the related Dose Distributions.
Villa Olmo, Como October 2001F.Giordano1 SiTRD R & D The Silicon-TRD: Beam Test Results M.Brigida a, C.Favuzzi a, P.Fusco a, F.Gargano a, N.Giglietto.
Measurement of Radiation: Instrumentation&Techniques Part Three
Purpose N-isopropylacrylamide (NIPAM) polymer gel dosimeters were employed to verify the dose distribution of clinical intensity modulated radiation therapy.
Thickness of CZT detector 110 MeV140 MeV DETECTOR A (1 mm CZT + 5 mm CZT) DETECTOR B (1 mm CZT + 10 mm CZT) DETECTOR C (1 mm CZT + 15 mm CZT) A. Generation.
Considerations on the possibility of Phase Contrast Mammography using ICS sources B. Golosio a, P. Delogu b, I. Zanette b, M. Carpinelli a, G. L. Masala.
Commissioning of a commercial treatment planning system for IMAT and Dose Painting treatment delivery. G. Pittomvils 1,,L. Paelinck 1, F. Crop 2, W. De.
The Effects of Small Field Dosimetry on the Biological Models Used In Evaluating IMRT Dose Distributions Gene Cardarelli,PhD, MPH.
Rapid Arc Treatment Verification: post evaluation on Delta-4 and proposal of a new verification protocol G. Pittomvils 1,,L. Paelinck 1, T. Boterberg 1,
Development of elements of 3D planning program for radiotherapy Graphical editor options  automated enclose of contour  correction of intersections 
E. Mezzenga 1, E. Cagni 1, A. Botti 1, M. Orlandi 1, W.D. Renner 2, M. Iori 1 1. Medical Physics Unit, ASMN-IRCCS of Reggio Emilia, Italy 2. MathResolution.
CONFIDENTIAL MATERIAL Michele Togno - II Annual ARDENT Meeting, Milan – October, 14 th D Ionization Chambers Array for Clinical Applications.
General Engineering Research Institute
CHAPTER 3 DOSE DETERMINATION FOR EXTERNAL BEAMS
INTERCOMPARISON P3. Dose distribution of a proton beam
Development and characterization of the Detectorized Phantom for research in the field of spatial fractionated radiation therapy. D. Ramazanov, V. Pugatch,
Template Matching Can Accurately Track Tumor Evaluation of Dose Calculation of RayStation Planning System in Heterogeneous Media Huijun Xu, Byongyong Yi,
Geant4 at IST Applications in Brachytherapy
P. Rodrigues, A. Trindade, L.Peralta, J. Varela
Technical Advances of Radiation Therapy for Thymic Malignancies
Innovations in the Radiotherapy of Non–Small Cell Lung Cancer
N. Belcari, F. Attanasi, V. Rosso , A. Del Guerra
Hot and cold spots are common problems associated with planning:
Surface doses of flattening filter free beams with volumetric modulated arc therapy dose delivery for breast cancer  Jan Seppälä, Aleksi Voutilainen,
N. Belcari, F. Attanasi, V. Rosso , A. Del Guerra
Presentation transcript:

Test of the proposed method Introduction CCD Controller CCD Illuminator gel Filter 585nm Assembling the phantom before its irradiation. The phantom, ready to be irradiated at a 60 Co unit. Phantom for test measurements This phantom offers the opportunity to select the number of gel dosimeter layers to be inserted. Both phantom’s component (poystirene) and gel- dosimeter matrix have good tissue-equivalence to high energetic X-rays. The developed software for dose distributions’ rendering A suitable software has been developed, able to properly process the acquired dosimeters’ images to get the interactive rendering of dose profiles, surfaces and volumes, as well as isodose curves. Examples of graphical user interfaces: 1. Depth dose profiles Dose reliability has been tested by inter- comparing the obtained depth dose profiles with those measured with a cylindrical ionization chamber (Farmer, 0.6cc), in the same field configuration. The good agreement between results is evident. 60 Co Unit 2. Dose distributions’ imaging In the last decade, technological improvements of radiotherapy (RT) hardware and software have been significant and consequently the use and importance of RT in cancer treatment have increased greatly. A fundamental advance has been the development of external beam techniques aimed at dose delivery that is highly localized on the tumour volume, sparing at the same time most of the surrounding healthy tissues. These techniques include conformal RT as well as intensity modulated RT (IMRT). Experimental 3D rendering of in-phantom absorbed dose, with high reliability and good spatial resolution. In a tissue-equivalent gel matrix, a ferrous sulphate solution and the metal-ion indicator Xylenol Orange (XO) are infused. Ionizing radiation causes a conversion of ferrous ions Fe 2+ into ferric ions Fe 3+. Proposed method RADIATION Fe 2+ Fe 3+ The complex of XO with Fe 3+ produces visible light absorption around 585nm, with yield proportional to the absorbed dose. Then, this system (gel-dosimeter) acts as a continuum dosimeter. Grey-level (GL) images of light transmittance at 585nm are detected by a CCD camera, before and after the irradiation of the dosimeters. With the properly developed software, the stored images are propcessed with a semi-automatical procedure (recognition and registration through reference points; filtering and noise removal; artefacts removal; conversion to dose matrices…), until 3D dose distributions are obtained. The instrumentation for the optical imaging of gel dosimeters is transportable, and can be set up close to the radiation source, in order to perform image detection short time before and after gel dosimeter exposure. Gel dosimeters are in form of layers of convenient shape and thickness (1-3 mm). For the analysis, they are placed on a plane light source near a grey-level calibration standard. Planned dose distributions for a patient suffering prostate cancer. These methodological improvements require corresponding improvements in the dosimetry methods, in order to ensure that the values calculated with computer treatment planning systems (TPS), adopted in the clincal praxis, agree with the delivered dose distributions. Considering that traditional dosimeters (i.e. ion chambers, films, diodes or thermoluminescent detectors) are not well suited to this task, an alternative technique is proposed. Goal Some gel-dosimeters of different shapes and exposures Variation of optical density between irradiated samples and reference sample The method’s reliability has been verified comparing the obtained dose distributions with those measured by means of ionization chambers or calculated with Monte Carlo (MC) simulations (Penelope), adopting field geometries in which the last are reliable. In two different experimental configurations (both with Varian Clinac 2100C, E γ =18MV), dose profiles, dose surfaces, isodose curves and 3D isodose distributions have been obtained. For inter-comparisons, experimental results are reported together with treatment planning system (TPS) (Prowess 3D) calculations and with MC simulations (Penelope). phantom 3x2 field gel layers phantom 3x2 field gel layers ° 270° Configuration 1 (C1): Configuration 2 (C2): Conclusions Dose profiles along beam direction (a) and orthogonal to it (b) [C1] 3D distribution of relative isodoses for C1 (95% blue, 80% yellow, 40% red) 3D distribution of relative isodoses for C2 (95% blue, 80% yellow, 40% red) Relative isodose curves obtained with a single gel-layer (a), TPS (b) and MC (c) (95% red, 90% blue, 85% green, 80% yellow, 60% light blue, 40% orange) [C2] Dose surface obtained with a single gel- layer (a) and with MC simulation (b) [C2] (a) (b) (a) Dose profiles along beam direction (a) and orthogonal to it (b) [C2] (a)(b) (a) (b) Two different depth dose profiles measured with a single gel-layer and with a ionization chamber The proposed method allows reliable 3D imaging of absorbed dose with good spatial resolution. (c) Congresso del Dipartimento di Fisica Highlights in Physics –14 October 2005, Dipartimento di Fisica, Università di Milano A method for 3D imaging of absorbed dose in conformal radiotherapy M. Carrara *, G. Gambarini *,†, S. Gay *,†, L. Pirola * and M. Valente *,† * Dipartimento di Fisica, Università di Milano † INFN – Sezione di Milano Siemens Mevatron MX2 E γ =6MV