Bioinorganic Chemistry: Zn & its Toxic Congeners Deborah C. Bebout Chemistry Department The College of William & Mary.

Slides:

Advertisements

Similar presentations

Cadmium Carbonic Anhydrase (CdCA) Sustaining Life Using a Toxic Metal Ion

Advertisements

P u t y o u r h e a d o n m y s h o u l d e r.

Synthesis, Structures and Ethylene Oligomerization Reactivity of Transition Metal Complexes Supported by Multidentate Amidine-Based Ligands T. C. Jones,

Create a Table.

Kyle A. Grice Assistant Professor, Chemistry Dept. DePaul University hνhν detector potentiostat Created by Kyle A. Grice, DePaul University

Slide 2/21 Schedule Lecture 7: M-M bonds  -bonds and bonding in metal clusters Lecture 8: Rates of reaction Ligand-exchange reactions, labile and inert.

Oxidative Addition and Reductive Elimination Peter H.M. Budzelaar.

Zinc enzymes Lecture 7: Catalytic zinc Lewis acidity, substrate orientation and polarisation.

Stability of Siderophore Complexes and Other Tales Margaret Broz, Jadon Peck Chemistry Capstone Spring 2002.

Chem 440/540 Advanced Organic Spectroscopy Introduction What spectroscopic techniques would be useful in determining the structure of this compound? H-1.

Introduction to Natural Products Chemistry Cells of organisms - plants, fungi, bacteria, lichens, insects, animals - produce a large variety of organic.

Synthesis of [MoCp(CO) 2 (COCH 3 )(P(n-Bu) 3 )] : Investigation of an Air-Sensitive Migratory-Insertion Acknowledgments I’d like to thank the Advanced.

Further Attempts Towards the Synthesis of Benzo-Annelated Cross-Bridged Cyclam Synthesis of Cross-Bridged Benzocyclam The Department of Chemistry of the.

Amino Acids (20 different ones) Proteins = long chains of amino acids Structure: collagen, keratin Enzymes: perform reactions Receptors: signal changes.

Microwave- Assisted Synthesis of 1,3- Dimesitylimidazolinium Chloride Brittney Hutchinson Department of Chemistry, University of New Hampshire, Durham,

Pyridine Ligands. and the Stability of Birju Patel Johns Hopkins University December 19, 2007.

SSRL and Stanford scientists, collaborating with a team from UC Irvine, got the first look into the assembly of metal active center of nitrogenase, an.

International Conference and Exhibition on Biopolymers and Bioplastics

Template-Controlled Synthesis: Covalent Bond Formation Made Easy in the Solid State Leonard R. MacGillivray, University of Iowa, DMR Scientific.

Chemical Reaction Types. Synthesis Two or more elements or compounds combine to form a more complex product A + B  AB 2H 2 + O 2  2H 2 O 2Na + Cl 2.

Synthesis TETRAHYDROISOQUINOLINE-BASED PEPTIDOMIMETICS MIMICKING REVERSE TURN SECONDARY STRUCTURES Nicola Landoni, Giordano Lesma, Alessandro Sacchetti.

Design and Synthesis of Calixarene Scaffolds Bearing Hydrogen Bond Motifs Farzad Fani-Pakdel and Jason R. Telford Department of Chemistry, University of.

Recent Work by Matthew Davidson: Synthesis and Structure of Initiators for ROP of Cyclic Esters July 21, 2008.

Iron and Copper Transport via DMT-1 in HEK-293 Cells Alex Jackson, York College of Pennsylvania Biology Department Introduction Neurodegenerative diseases.

TEMPLATE DESIGN © Synthesis and Coordination Chemistry of the Novel Ligand N,N’-bis(2-pyridylmethyl)-bis(ethylacetate)-1,2-ethanediamine.

Bioinorganic Chemistry: Zn & its Toxic Congeners Deborah C. Bebout Chemistry Department The College of William & Mary.

Manfred Scheer Coordination Chemistry of Phosphorous Containing Compounds Angela Dann May 8, 2006.

The “Busch Catalyst”: A Remarkably Diverse Oxidation Catalyst 1)Original Goals and Rationale 2)Ethyl Cross-Bridged Cyclams are successful tight-binding.

Structural characterization of non- crystalline systems Biophysics and Synchrotron Radiation James E. Penner-Hahn Department of Chemistry & Biophysics.

Iron(III) sequestration by synthetic hydroxypyridinone siderophores and exchange with desferrioxamine B J. M. Harrington, 1 S. Dhungana, 1 S. Chittamuru,

Introduction to Natural Products Chemistry Cells of organisms - plants, fungi, bacteria, lichens, insects, animals - produce a large variety of organic.

Pb(II) and Hg(II) binding to de novo designed proteins studied by 204m Pb- and 199m Hg-perturbed angular correlation of γ- rays (PAC) spectroscopy: Clues.

LECTURE 5. СOMPLEX COMPOUNDS.REACTIONS OF COMPLEX FORMING. BIOLOGIC ACTIVE СOMPLEX COMPOUNDS. LECTURER: Professor A.D.DZHURAEV Department of Bioorganic.

Inorganic Faculty with Research Interests Presentation to 2/c Chemistry Majors February 22, 2016.

Ligands that Favor/Force the Formation of Tetrahedral Complexes with an Application in Bioinorganic Chemistry Marion E. Cass, Carleton College Michael.

Synthesis of Carbon Quantum Dots and Their Use as Photosensitizers Anthony J. Lemieux, Christine A. Caputo Department of Chemistry, University of New Hampshire,

Progress Towards the Synthesis and Characterization of a Copper(I)-Phenyl Complex Thabiso Kunene; Thora Maltais (‘09), Mark Ziffer (’11), Rebecca Conry.

Stabilizing Transition Metal-Arylthiolate Bonds via Secondary Sphere Hydrogen Bonding Ryan L. Hall and Samuel Pazicni. Department of Chemistry, University.

Page 1 This is page one. I’m talking about it now….

Engineering Chemistry CHM 406

5Fe3+ + 3Fe RO H2O + 14L → Fe8O12L ROH

Towards the Synthesis and Characterization of Copper(I)-Arene Compounds Using Phenyl- and Naphthyl-Appended NS2-Macrocyclic Ligands Thora R. Maltais.;

Applications of Ionic LiquiDS IN Rare EarthS

Name: Dr. Pramod B. Thakur Class: S. Y. B

Molecular Magnetic Switches

Zhongjing Li Advisor: Professor Wenfang Sun

Novel Organic-Inorganic Hybrid Cage Architectures

Chemistry Aqueous solution chemistry of Zn(II) and Cd(II) with L-DOPA

SOURCES OF DRUGS: Dr. Muthuraman A.

D I s , a ·.... l8l8.

CHEMICAL REACTIONS 4 types.

Synthesis of Potential Molecular Wire Candidates

Investigation of the Effect of Ligands on Metal-to-Ligand Charge Transfer Transitions using d10-complexes of Group 11 Elements Evangelos Rossis, Roy Planalp,

Self-Assembled Luminescent Networks of Copper(I) Cyanide

Boranes as Lewis Bases and the Synthesis of Metallaboratranes

Equilibrium Studies of Self-Assembly Events

Rebecca R. Conry,* Cedric Owens, and Michelle Kim

Synthesis and Metal Coordination of Phosphacrown Compounds

Rational self assembly of macromolecular arrays for optimized light harvesting and photocatalytic hydrogen production Jonas I. Goldsmith, Department of.

The Periodic Table Part I – Categories of Elements

Transition Metal-Templated Reduction of Carbon-Fluorine Bonds:

' 1 A ./.\.l+./.\.l

Zhaohua Dai Department of Chemistry and Physical Sciences

2-naphthyl pendant aryl groups in quest of copper(I)-arene complexes

Boranes as Lewis Bases and the Synthesis of Metallaboratranes

Development of New Reactions Based on Decarboxylative Metalation

Synthesis of Low-Coordinate m-Terphenyl Isocyanide Complexes

Coordination Studies of a Library of Water-Soluble Bis-Phosphines Derived From 1,3,5-Triaza-7-phosphaadamantane (PTA) Donald A. Krogstad, Department of.

Presentation transcript:

Bioinorganic Chemistry: Zn & its Toxic Congeners Deborah C. Bebout Chemistry Department The College of William & Mary

Zn Cd Hg Essential to all known life forms Thalassiosira weissflogii produces Cd(II)-dependent carbonic anhydrase in Zn(II) limiting conditions …or not IIB …but generally considered toxic to all known life forms Broad toxicity of Hg(II) likely precludes any physiologically beneficial role …LD 50 (ZnCl 2 ) 350 mg/kg, rat (oral)

L Coordination number variability Coordination geometry flexibility Rapid exchange M MM L 2 LLLL 3 LL 45678

New Insight NMR X-Ray ESI-MS >60 new complexes Slow exchange J( 199 Hg 1 H) J( 111/113 Cd 1 H)

Zn Cd Hg Spectroscopically silent …or not to see 12.3% 113 Cd spin & 12.8% 111 Cd with spin I = ½ 16.8% 199 Hg with spin I = ½

Julie A. Viehweg, Sarah M. Stamps, Jennifer J. Dertinger, Robert L. Green, Katherine E. Harris, Raymond J. Butcher, ‡ Erica J. Andriole, J.C. Poutsma, Steven M. Berry, Deborah C. Bebout* “A Synthetic Model of Hg(II) Sequestration” Dalton Transactions 2010, 39, 3174.

W. Lai, S.M. Berry, A. Q. A. Tran, W. P. Kaplan, M. S. Hain, J.C. Poutsma, R. J. Butcher, R. D. Pike and D. C. Bebout “Carbonate-templated self- assembly of an alkylthiolate-bridged cadmium macrocycle” Inorg. Chem. 2013, 52, Y. Xu, L. Feng, P.D. Jeffrey, Y. Shi, F. M. M. Morel Nature 2008, 452, 56.

 Organic synthesis  Purification  Coordination Chem  Routine NMR  IR, UV/Vis, etc.  Multinuclear NMR  ESI-MS  X-ray Crystallography  Scientific writing  Scientific presentations

« Recruiting Underclassmen « Please come talk to me if interested! « ISC 2039 & 2028 I’M A HEAVY METAL FAN. ME TOO!