Fabienne Cournarie Director of Public Affairs, SIMV France ETPGAH Mirror Groups meeting Tuesday 23 November 2010 Tuesday 23 November 2010 The French Network for Animal Health

Why? Implementation, at the national level, of the EU guidelines and objectives defined in the ETPGAH Action Plan = « Mirror Groups » How? Initiative of the French Ministry of Agriculture, launched in May 2007 French Network for Animal Health

Government Regulatoy authorities French Network for Animal Health Industry Vet schools Public research organisms Diagnostic labs Ministry of Agriculture (and Fisheries) French Agency for Sanitary Safety (ANSES) Animal Health Industry, united in SIMV National Veterinary Schools (ENV) National Institute of Agronomy Research (INRA) Agricultural Research Centre for International Development (CIRAD) Technical Veterinarians Union (SNGTV) Sanitary Defence Groups (farmers) (FNGDS) Public Veterinary Diagnostic Laboratories (ADILVA) Who? Farmers Vet organisations

New members in 2010: AVEF : Veterinary organization for horses welfare AFVAC : Veterinary organization for companion animal care INSERM : Public research organism ITAB : Technical institute of organic farming French Network for Animal Health Who? Stakeholders covering the whole range of animal health professionals

Missions French Network for Animal Health EUROPE FP-7 Public researchPrivate research Users: Veterinarian Farmers French Authorities

Structure French Network for Animal Health To provide solutions to the immediate needs Emerging diseases Antimicrobial resistance Steering Committee Europe Public Private cooperation 4 working groups

Working group 1: “orphan drugs” availability French Network for Animal Health 1. Solved Issues Either by maintaining enough stocks in case of TU or by succeeding in the idea of preparing a CTD Anthrax vaccine (sporadic cases): TU Q fever : CTD in progress tuberculin for ID tests Local anaesthetics for ruminants: proposal made to CVMP Oral sedation for ruminants : CTD? Dexamethasone ovine Ruminant cryptosporidosis : CTD in progress Very positive output. Having all actors (regulatory authorities, manufacturers, veterinarians and farmers) around the same table has definitely helped to define rapid and pragmatic solutions.

Working group 1: “orphan drugs” availability French Network for Animal Health 2. Issues which require a European involvement Paratuberculosis vaccine: an attenuated form is required Histomonosis: no treatment available Products for bee disease treatment To evaluated needs at the level of Europe To federate expertise and means

Working group 2: emerging disease French Network for Animal Health 1. Concerted list of immediate (“operational”) research needs: blue tongue is a priority Epidemiology, diagnostic tools, molecular typing, BTV status in wildlife… Consequences on reproduction performances, on husbandry practices Economical impacts (direct and indirect) Vector biology and control measures Vaccines (safety and efficacy in “minor species”) 2. Longer-term research: pathogenesis, immunology

French Network for Animal Health RFSA achievements on blue tongue: Government funded research programs (total of 1,5 M€ for Short Term perspectives) : 10 projects were funded Meeting on RFSA initiative for the review of the on going research projects on BTV (March 18 th 2010 ) : among them 4 priorities were selected Success because achieved in less than 2 years Working group 2: emerging disease

Working Group 3: Europe French Network for Animal Health 1.Links with EMIDA – ERA NET, Discontools First EMIDA common calls:  77 pre-proposals were received, 45 were shortlisted, only 12 were identified for funding, 8 projects have french partners  projects with french partners: “vector borne disease” : 2 “major infectious diseases affecting production”: 5 “aquaculture”: 1

Working Group 3: Europe French Network for Animal Health 2.FP7  Analyse the European project calls : analyse the reflection paper of FP7 projects calls and share the information with its partners  Propose to the European commission : based on the FP7 projects calls and/or on, propose projects to the European commission  Propose to the European commission : based on the FP7 projects calls and/or on RFSA coordinated topic priorities, propose projects to the European commission

Working Group 3: Europe French Network for Animal Health List of topics proposed to the FP7 theme 2 Program committee by the french ETPGAH mirror group in January 2010  Main line 1, Animal health and non food-borne zoonoses Topics: Ruminant pathogenic mycoplasmas: from genomics to the development of new control strategies The assessment of the within-herd dynamics of endemic pathogens in pigs The priority of these topics has been confirmed in september 2010

Working Group 3: Europe French Network for Animal Health  Main line 2, Food borne zoonoses : Main line 3.1 Animal health and non-food borne zoonoses:  Main line 3.1 Animal health and non-food borne zoonoses: List of topics proposed to the FP7 theme 2 Program committee by the french ETPGAH mirror group in January 2010 (continue) Topics: Knowledge of Trichinella nurse cell Trichinella control Topic: Alternative/complementary medication in organic/low-input livestock systems

Working Group 3: Europe French Network for Animal Health New topics proposed to the FP7 theme 2 Program committee by the french ETPGAH mirror group in September 2010 Q Fever “Resistant forms of C. burnetii: characterisation, role in maintenance and transmission of the disease, exploration of prophylactic strategies” “Study of genomic plasticity and biodiversity of C. burnetii strains populations and relationships to pathoadaptation and epidemiological factors” Bee diseases “Development and Harmonization of tests in diagnosis and bee research (HARMONY)” Main line: 3.1: Animal health and non food-borne zoonoses

French Network for Animal Health Topic: Integrating systems biology outputs to generate cutting edge vaccines and predictive protection in farm animals Main line 1.2: 'Omics technologies', systems biology and other basic sciences in farm animals. Gaps:  Bioinformatics, systems biology, immunology  Epigenetics  Host-pathogen interaction, identification of protective antigens in complex pathogens  Cutting edge vaccinology platform 2.FP7 (continue) Working Group 3: Europe

French Network for Animal Health Main line 3.2: Food-borne zoonoses, antimicrobial resistance. Gaps:  antimicrobial resistance 2.FP7 (continue) Topic: Management of increased antimicrobial resistance in animal populations

Group 4: Private-public cooperation French Network for Animal Health 1.Identification of subjects of interest for possible private-public cooperation: done Antimicrobial resistance 2.To define the rules for a productive PPP cooperation (resolution of legal aspects, technical issues…): next step 3. Links with ARIIS : Brings together all industries involved in health (human,animals…) Calls for projects from the French government to create institute to enhance the translational research (hospital, university, biotech/pharma companies) Infectious disease institute was proposed including zoonoses

French Network for Animal Health  Research on epidemiology and physiopathology of bacterial disease in animals  Alternative to antibiotics  How pathogenic are transmitted from animals to human? Contact, alimentation, environment  Economics analysis  Which strategies for the treatment of animals with antibiotics? Antimicrobial resistance: 5 priorities A national committe for the cautious use of antibiotics will be launched in January 2011

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