How to analyse dust in the lung Dr. med. Andreas Burger Zentrum für Medizinische Lehre in der Medizinischen Fakultät der RUB (Center of Medical Education in the Faculty of Medicine) Lehrender des Institutes für Pathologie Ruhr-Universität Bochum (Teacher of the Institute of Pathology) Ruhr-University Bochum Lecture Moscow

© Dr. med. Andreas Burger 2012 How to analyse dust in the lung, lecture Irkutsk That is the Problem: A white lung

–Silikoses –Asbestoses –Hardmetalfibroses –and so on Lungdiseases conditional on dust © Dr. med. Andreas Burger 2012 How to analyse dust in the lung, lecture Irkutsk

Pulmonal Hypertonus (> 25 mm Hg or 325 kPa) Cor pulmonale –Hypertrophy –and/or –Insufficiency of the right heart Also often causes obstruction Complications © Dr. med. Andreas Burger 2012 How to analyse dust in the lung, lecture Irkutsk

Coal miners Workers in casting Gum manufacture Welding Coating Working with Pesticids, Herbicids, Dioxin Oilrefinerie Cane-sugar manufacture Professions with higher risks on lung diseases with dust © Dr. med. Andreas Burger 2012 How to analyse dust in the lung, lecture Irkutsk

Safe: Arsen, Asbest, Bichlormethylester, Chrome- u. Nickelcompounds, polyzyclic aromatic coal-hydrogens (pacs), Radon, venom gases Suspected: Cadmium, chlorined Toluoles, Dimethylsulfat, Epichlorhydrids, Mineral- fibres, Lead, Silicates, Talcum In question: Acrylnitrites, Beryllium, Vinyl- chloride Dusts with higher risks for lung cancer © Dr. med. Andreas Burger 2012 How to analyse dust in the lung, lecture Irkutsk

gross anatomy of the left lung © Dr. med. Andreas Burger 2012 How to analyse dust in the lung, lecture Irkutsk

subpleural dust and emphysema © Dr. med. Andreas Burger 2012 How to analyse dust in the lung, lecture Irkutsk

Lungfibroses © Dr. med. Andreas Burger 2012 How to analyse dust in the lung, lecture Irkutsk

Microscopy © Dr. med. Andreas Burger 2012 How to analyse dust in the lung, lecture Irkutsk

E nergy D ispersive X -Ray Analysis © Dr. med. Andreas Burger 2012 How to analyse dust in the lung, lecture Irkutsk

Asbestbodies © Dr. med. Andreas Burger 2012 How to analyse dust in the lung, lecture Irkutsk

Trans Electron Microscopy © Dr. med. Andreas Burger 2012 How to analyse dust in the lung, lecture Irkutsk

Trans-, Scanning Electron Microscopy © Dr. med. Andreas Burger 2012 How to analyse dust in the lung, lecture Irkutsk

E nergy D ispersive X -Ray Analysis ( Spectroscopy ) Ferric oxide © Dr. med. Andreas Burger 2012 How to analyse dust in the lung, lecture Irkutsk

E nergy D ispersive X -Ray Analysis © marl.iastate.edu Liquid nitrogen Analysis unit by Thermo Scientific – Kevex X-Ray Products 320 El Pueblo Road Scotts Valley, CA USA © Dr. med. Andreas Burger 2012 How to analyse dust in the lung, lecture Irkutsk

E nergy D ispersive X -Ray Analysis © Dr. med. Andreas Burger 2012 How to analyse dust in the lung, lecture Irkutsk

Dust Inflammation Fibrosis Welding smoke in this case © Dr. med. Andreas Burger 2012 How to analyse dust in the lung, lecture Irkutsk

Gardolineum Contrasting in angiographics New Entity © Dr. med. Andreas Burger 2012 How to analyse dust in the lung, lecture Irkutsk

White lung - lungfibrosis 26 year old man Heroin disease Heroin extended with talcum © Dr. med. Andreas Burger 2012 How to analyse dust in the lung, lecture Irkutsk

Talcum powder © Dr. med. Andreas Burger 2012 How to analyse dust in the lung, lecture Irkutsk

EDX-spectrum of Talcum Powder © Dr. med. Andreas Burger 2012 How to analyse dust in the lung, lecture Irkutsk