Dan-Thanh Nguyen Biology 402 March 20, 2012. Symptoms:  Fever  Sore throat  Weakness  Headache  Muscle aches  Diarrhea  Vomiting  Severe hemorrhaging.

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Presentation transcript:

Dan-Thanh Nguyen Biology 402 March 20, 2012

Symptoms:  Fever  Sore throat  Weakness  Headache  Muscle aches  Diarrhea  Vomiting  Severe hemorrhaging

/

 Zaire (Democratic Republic of Congo)  Sudan  Cote d’Ivoire (Ivory Coast)  Reston  Bundibugyo

Nucleoprotein Virion protein 35 Virion protein 40 Virion protein 30 Virion protein 24 Glycoprotein Soluble glycoprotein polymerase

 Hepatocytes  Endothelial cells  Dendritic cells  Monocytes  Macrophages

 Dolnik, O.; L. Kolesnikova, and S. Becker. “Filoviruses: Interactions with the host cell.” Cellular and Molecular Life Sciences Vol  “Ebola haemorrhagic fever.” World Health Organization. Dec  “Ebola virus disease.” Wikipedia.  Feldmann, Heinz; Steven Jones, Hans-Dieter Klenk; and Hans-Joachim Schnittler. “Ebola virus: from discovery to vaccine.” Nature Reviews Immunology. Vol (August 2003).  Geisbert, Thomas et al. “Mechanisms Underlying Coagulation Abnormalities in Ebola Hemorrhagic Fever: Overexpression of Tissue Factor in Primate Monocytes/Macrophages is a Key Event.” Journal of Infectious Diseases. Vol  Mohamadzadeh, Mansour; Leiping Chen; and Alan L. Schmaljohn. “How Ebola and Marburg viruses battle the immune system.” Nature Reviews Immunology. Vol (July 2007).  Takada, Ayato. “Filovirus Tropism: Cellular Molecules for Viral Entry.” Frontiers in Microbiology. 06 February

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