Using Fluorescence X-rays for Non-invasive Biopsy Team members: Savannah Gill Kelvin Lin Mike McHugh Trey Reece Derric Williams Advisors: Dr. Frank Carroll Dr. Ed Donnelly Mr. Robert Traeger

Project Background/Social Impact Current Methods are Invasive Our Project Hopes To – Rid Detection Process of Needles, Anesthetic, & Pain – Reduce radiation dose to patient – Rid of contrast agent – Reduce Time & Complications

Project Goals Design beamline components Isolate rings from small angle scattering Figure out which rings represent which elements Distinguish signals from noise

Facilities/Resources W.M. Keck Free Electron Laser (FEL) Center at VU – Monochromatic X-ray machine – Specimen for imaging Vanderbilt BME Department – Computers with necessary software

Project Description X-Ray Fluorescence

Project Description Monochromatic X-ray Specimen

Project Description Task 1: Decrease the size of the x-ray

Task 2: Block off the extra x-ray Project Description

Task 3: Determine Material d R Project Description

Market Potential Conventional Methods Mammography – High False Negative Rate – Cheap, Simple, Ubiquitous MRI – High False Positive Rate – More Sensitive – More Costly – Safer Mammography X-Ray Image

Market Potential Screening with Monochromatic X-Rays Requires sophisticated equipment Costly Greater sensitivity Safer than conventional mammography Potential use for biopsy upon positive or uncertain mammography

Work Completed Completed NCIIA Proposal Researched Journals Constructed Website Submitted Progress Report Finalized team issues

Work in Progress Complete Radiation Safety Course Collimation Technique Low Angle Scattering Geometry Calculation Determine Source and Object Distance Weekly advisors meeting and weekly team members meeting

Future Work Assess our Financial Needs Gather Appropriate Materials Conduct experiments and perform data analysis

Questions?