Winthrop INBRE Update Presented to SC-INBRE External Advisory Committee November 2005

CHE Research Performance Data for South Carolina State Teaching Universities Teaching University FY03-04 Sponsored Research* S.C. State Univ.$3,470,643 College of Charleston$3,418,957 Coastal Carolina Univ.$1,382,317 U.S.C. – Aiken$ 699,707 Francis Marion Univ.$ 284,113 U.S.C. – Upstate$ 220,597 Winthrop University$ 217,617 Citadel$ 101,570 Lander Univ.$ 11,713 U.S.C. – Beaufort$ 7,613 Total $9,814,840 *based upon CHE Step 2 Research numbers (representing 30% of FY sponsored research expenditures) obtained from accessed Nov 20, 2005.

Defining The Winthrop Experience: What We Promise Students and Families “ As a predominantly residential learning university, Winthrop focuses on fully engaging students in developing the capacity to become leaders in their professions and leaders in their communities. Over their years of undergraduate study, Winthrop students have the opportunity to participate in a highly personalized, engaging and progressively developmental series of experiences that will build within them the capacity to read, write and think about themselves and the world around them in ever more meaningful and purpose-driven ways, both personally and professionally. Slide from President DiGiorgio’s “Education by Design” April 2005 Presentation to Winthrop

Defining The Winthrop Experience: What We Promise Students and Families “ At Winthrop, a high-achieving, diverse student body interacts with talented, national-caliber faculty and staff in ways intentionally designed to prompt thought, reflection and a life-long quest for knowledge and understanding. Conversations that begin in classrooms extend across the campus community, complemented by an extraordinary range of cultural events, service-learning activities, guided research and other transformational opportunities.” That is The Winthrop Experience. Slide from President DiGiorgio’s “Education by Design” April 2005 Presentation to Winthrop

Winthrop’s INBRE Objectives 1)Dramatically expand biomedical research capacity 2) Increase the competitiveness of faculty for external biomedical research funding 3)Establish a strong biomedical research infrastructure core 4)Provide students with a strong interdisciplinary foundation in the biomedical sciences 5)Increase the number and the percentage of biology and chemistry graduates that enter biomedical research fields 6)Recruit, train, and mentor students from underrepresented groups to increase the number and the percentage of female and minority graduates that pursue biomedical research

Winthrop University Organization President (Dr. Anthony J. DiGiorgio) –VP for Academic Affairs (Dr. Moore) INBRE Steering Committee ex-officio nonvoting member Dean, College of Arts and Sciences (Dr. Boyd) INBRE Steering Committee ex-officio nonvoting member –Chairs, Departments of Biology (Johnston) & Chemistry (Owens) Winthrop INBRE Project Co-Directors »Chemistry Faculty (Lammi, Parker, and Sumter- INBRE Investigators; Calloway – INBRE Core Lab Director) »Biology Faculty (Dimaculangan, Glasscock, and Westover- INBRE Investigators)

The Winthrop INBRE Experience:

Winthrop Steering Committee (Meeting Dates of Sep 9, 2004 & Dec 2, 2005) Ralph Meyer Director, Biology Division, Orthopaedic Research Laboratory,Carolinas Medical Center,Charlotte, NC Frank Berger Director, Center for Colon Cancer Research and Professor, Department of Biological Sciences, USC Merle Schuh Councilor, Council of Undergraduate Research and Professor of Chemistry, Davidson College Gary Schwartz Scientific Director, Prostate Cancer Center for Excellence, Comprehensive Cancer Center of Wake Forest University, Winston Salem, NC Debra Boyd (ex-officio nonvoting member) Dean of the College of Arts and Sciences, Winthrop University Tom Moore (ex-officio nonvoting member) Vice-President for Academic Affairs, Winthrop University

Project Investigators (Mentors) Dwight Dimaculangan (Carver - USC) Stem Cell-Augmented Repair in a Bioengineered Cardiac Model Laura Glasscock (Church – UNC,Teigland - CMC) The Role of Thrombomodulin in Prostate Cancer-Associated Angiogenesis Robin Lammi (Dawson - USC, Holten - Wash U) Monitoring Metal-Ion Concentration and Metal-Induced Conformational Change at the Level of Single Ions and Enzymes Chasta Parker (Sodetz – USC, Lebioda - USC) Structural Studies of a Recombinant Membrane Interacting Region of Complement Component C8a and Adiponectin Membrane Receptor 1 Takita Sumter (F. Berger - USC) Functional Mapping of High Mobility Group A1 (HMGA1) Binding Domains Required for Tumor Transformation Kristi Westover (Hughes - USC) Hepatitis B Virus: Adaptive Evolution of Immune Recognition and Evasion

Core INBRE Lab Director + Four Scientists

Infrastructure: Objectives & Progress 1)Procure $100K of biomedical research equipment – Planning completed and quotes obtained in June, orders delayed until August 17, 2005, $117K now on order, ~2/3 of equipment now at Winthrop 2)Install cold room - Ordered and partially installed, several parts on backorder, Jan 2006 expected operational date 3)Make necessary facility modifications and equip offices for staff scientists – Classroom being converted (Dec ’05 completion), office furniture ordered, completion in Jan ’06. 4)Complete four staff scientist searches - All four ongoing: »Two MS Scientists (12 month “Research Staff Scientist” positions, 100% Core time) interviews to be conducted soon (Feb 1, 2006 start) »Two Ph.D. Scientists (9 month “Assistant Professor of Biology (Chemistry)” positions, 50% core time) Aug 15, 2006 start

Faculty Development: Objectives & Progress 1)AY06-07: Three Faculty submit research proposals; AY07-08 and all succeeding years: Six biomedical research proposals submitted annually »$165K proposal submitted to NSF RIG program in July 2005 by Takita Sumter (PI) 2)AY 04-05: Four staff scientist positions approved. AY 05-06: Laboratory chemist position approved. AY 05-06: Obtain FTE approval for two regenerative medicine faculty positions. »Four Staff Scientist INBRE FTE’s submitted by Winthrop to South Carolina during AY04-05 were disapproved by the State. »Renewed requests for these four and the remaining additional three FTE’s have been submitted to the Dean for inclusion within Winthrop’s AY05-06 request to State.

Student Development: Objectives & Progress 1)AY 09-10: At least 20 students engaged in biomedical research projects »Summer 2005: 12 Students engaged in biomedical research, half supported by Winthrop Research Council Funds. September 9, 2005 poster session. »Fall 2005: 13 Students engaged in biomedical research 2)AY 09-10: 20 students make conference presentations and five students are co-authors on peer-reviewed publications from biomedical research »Three student presentations at national conferences in AY04-05, six at SCAS in Mar 05 »Three abstracts submitted for spring 2006 national ACS meeting; two abstracts for 2006 ASBMB submitted, multiple NCUR submissions being prepared. 3)AY 05-06: Develop a formal recruitment plan. A recruitment plan will be developed after the initial advisory committee meeting in December 4)AY 04-05: Continue discussions and review similar programs being implemented. AY : Develop integrated biomedical science curriculum. AY 06-07: Gain curricula approval for biomedical program »Discussions on the biomedical curriculum will be a focus after the advisory committee meeting in December ASBMB and BIO2010 recommendations being examined

Summary of Budget Changes $11,916 Balance from Summer Salaries + Balance due to separate student funding from May 15- June 30, INBRE start date of July 1, 2005, and one Project Investigator’s maternity leave –These funds being reallocated for equipment upgrade (centrifuge accessories), for critical supplies, for a spring graduate student stipend, and for undergraduate research assistantships $3,000 mentor and advisor travel expense budget allocation to also be used to cover Winthrop Steering Committee meeting Dec 2, 2005

Investigator-Mentor Interactions and Progress of Research Mentor-Investigator Interactions –All six projects interacting with mentors through s & phone calls –Four mentor visits to Winthrop – Dawson (2), Sodetz, and Berger –Many investigators have made multiple visits to mentor sites – Parker USC, Dimaculangan USC, Sumter USC, Glasscock CMC, Lammi Wash U (Jan ’06), Westover USC –Project progress reports all providing evidence of active mentorship Research Progress Lessons Learned to Date –Investigator time is a critical commodity –At risk ordering is a must, shift procurement burden from investigators –Need for staff scientist core support –Increased availability of Core Lab Director during summer –Service contracts on critical equipment items –Need to replace obsolete equipment to improve research productivity –Need for improved communications with facilities management

Equipment Infrastructure Continuous Modernization Plan Funds Required to Sustain Equipment Infrastructure –Annual funds to operate and maintain –Annual funds to update and upgrade –Annual funds for service and repair –Capital funds for replacement when obsolete –Capital funds for new technologies Possible Sources of Equipment Funds –Increased operating budgets (University equipment fees) –Winthrop Foundation equipment endowment and grant match accounts –Faculty development of external equipment grants –Reinvestment of indirect costs from external grants –Increased student laboratory fees –User fees from local industry –Revenues from summer school –Supplemental State allocations for science equipment