Monday 20 th July 2009 Parkinson’s Summerschool A Personal Perspective On Parkinson’s Tom Isaacs Co-Founder – Cure Parkinson’s Trust Board Member – European PD Association Steering Group – World Parkinson’s Congress

Tom’s Tiny (but tasty) Two-minute Turkey Teach-in 4 slides 30 seconds each Parkinson’s can affect anyone at age It is idiopathic – of unknown cause Increasingly it is being linked to genetics and environmental factors The shaking and immobility are caused by a deficit of dopamine in the brain Dopamine is the chemical messenger which controls movement You do not need an electric toothbrush if you have Parkinson’s

Tom’s 2-minute Turkey Teach-in. Treatment for Parkinson’s is usually with a combination of the following medications: L-dopa Agonists – patch or pill COMT Inhibitors MAOB Inhibitors Amantadine After a 2-10 years of using L-dopa-induced dyskinesia is common In later stage Parkinson’s the following further treatments are available Apomorphine – rapid response agonist by injection Duodopa – continuous dopaminergic stimulation via pump from duodenum Deep brain stimulation (DBS) – electrical implant (pacemaker for the brain) No treatment yet said to be “disease modifying” except arguably Azilect (MAOB) All Parkinson’s medicines sound like they are from an Italian restaurant menu E.g. Ropinorole, rotigotone, tolcapone, duadopa, selegeline, cabergoline, stalevo.

Tom’s 2-minute Turkey Teach-in. Current Avenues of Parkinson’s Research –Genetic profiling and biomarkers –Gene Therapy –Neurotrophic factors and neurotrophic factor inducers –Alpha–synuclein disaggregation –Calcium channels/Anti-inflammatories –Delivery Mechanisms: Viral vectors, nanotechnology, novel peptides –Stem cell therapy –Drugs for other indications e.g. Hypertension and Diabetes

Tom’s 2-minute Turkey Teach-in. COMMON SYMPTOMS INABILITY TO COMMUNICATE e.g. Parkinson’s Mask DEPRESSION BEHAVIOURAL PROBLEMS COGNITIVE ISSUES/DEMENTIA FREEZING / RIGIDITY / INABILITY TO MOVE DROOLING / DRIBBLING SEXUAL PROBLEMS – (hyper or low drive) CONSTIPATION / INCONTINENCE SPASM DYSTONIA DYSKINESIA INSOMNIA TREMOR LOSS OF SENSE OF SMELL AND TASTE DYSPHAGIA / DIFFICULTIES WITH SWALLOWING PARANOIA ON/OFF FLUCTUATIONS and lots more!!!

CARLOS

HUGO

BARRY

Monday 20 th July 2009 Parkinson’s Summerschool A Personal Perspective On Parkinson’s Tom Isaacs Co-Founder – Cure Parkinson’s Trust Board Member – European PD Association Steering Group – World Parkinson’s Congress

“The greater part of our happiness or sadness is not dependant on our circumstances but on our disposition”

PD CARE ISSUES Communication Multi-disciplinary teamwork Rigidity, inflexibility and an inability to move forward Flamboyant gestures - achieve nothing Focus Leaving it too long before next medication PD CURE ISSUES Communication Multi-disciplinary teamwork Rigidity, inflexibility and an inability to move forward Flamboyant gestures - achieve nothing Focus Leaving it too long before next medication

CARE CURE U