Organ-System-Based Integration of Biochemistry: Cells Do It; Can We Do It as Well? Eric Niederhoffer Southern Illinois University School of Medicine

Slides:

Advertisements

Similar presentations

High School Version.  In 1904, a student from the West Indies came to a Chicago physician, Dr. James Herrick, with a puzzling condition. Below is a summary.

Advertisements

Sickle Cell Anemia Sickle Cell anemia is an inherited red blood cell disorder. Normal red blood cells are round like doughnuts, and they move through small.

Classification of anemia

Sickle-Cell Anemia Homozygous Dominant (HbA, HbA) – normal hemoglobin Homozygous Recessive (HbS, HbS) – abnormal hemoglobin Heterozygous (Hb A, Hb S) –

Eric Niederhoffer SIU-SOM What affects the normal functions of an erythrocyte? A 4-year-old African boy is brought in by his adoptive parents who say that.

Biological pathway and systems analysis An introduction.

Pathology Introduction to course Alan Stevens Jim Lowe.

Hemoglobin (Hb) Hb is found in RBCs its main function is to transport O2 to tissues. Structure: 2 parts : heme + globin Globin: four globin chains (2 α.

Sickle Cell Disease normal red blood cells sickled red blood cells

Welcome to Pathophysiol ogy Pathophysiol ogy. Contents of the lecture 1 Introduction 2 Conspectus of Disease.

OSU College of Medicine LeadServeInspire Curriculum.

16 November 2004Biomedical Imaging BMEN Biomedical Imaging of the Future Alvin T. Yeh Department of Biomedical Engineering Texas A&M University.

Course Code Course Title Credits BMS 500 Responsible Conduct of Research 1 BMS 510F Biochemistry and Cell Biology 10 BMS 512 Critical Thinking 1 BMS 523A.

Australian Medical Education - Is it Good for Our Health? Helen C Beh CEO, Australian Orthopaedic Association Helen C Beh CEO, Australian Orthopaedic Association.

Step 1 includes test items in the following content areas: anatomy, behavioral sciences, biochemistry, microbiology, pathology, pharmacology, physiology,

Summary of Metabolism.

Signaling and the Signal Transduction Cascade. Question?????? External Stimulus Inside cell Nucleus, Gene transcription Other cellular effects.

Copyright © 2009 Pearson Education, Inc., publishing as Pearson Benjamin Cummings C h a p t e r 1 An Introduction to Anatomy and Physiology.

WELCOME TO PENN MED BE READY TO BE AMAZED!!!!. THE BEST CURRICULUM ON THE PLANET!!! Basic Science Courses are 3 Semesters! Basic Science Courses are 3.

Chromosomes carry genetic information

University of Pennsylvania SOM Integrating Basic Sciences and Patient Care in a Core Clerkship Curriculum: Why do we care about integrating basic science.

Cell Biology Course Info and Introduction. What is Cell Biology? Investigation of Biological Systems –Biochemistry –Molecular Biology –Genetics/Molecular.

Practical Clinical Hematology. What is Sickle cell: Sickle cell anemia is an inherited disorder that leads to the production of an abnormal hemoglobin.

A Doctoral Curriculum in Transition Shoumita Dasgupta, Ph.D. A Case Study of Boston University’s Graduate Medical Sciences Curriculum Reform.

BASIC BIOCHEMISTRY MLAB Introduction. INTRODUCTION TO BASIC BIOCHEMISTRY Biochemistry can be defined as the science concerned with the chemical.

Bioinformatics.

Introduction to Pathology

Chapter 7 Disorders of Blood Cells Lecture 7 The Nature of Disease Pathology for the Health Professions Thomas H. McConnell.

Faculty of Medical Sciences School of Biomedical Sciences Dr Edwin Williams Director of Studies

Chapter 11: Cell Communication. Essential Knowledge 2.e.2 – Timing and coordination of physiological events are regulated by multiple mechanisms (11.1).

1 Biochemistry & medicine introduction. 2 1 、 definition  Science concerned with chemical basis of life.

Practical Clinical Hematology

The main web site for Dental Biochemistry is at: Since you’ve all had biochemistry before: you should recognize about 2/3.

Relationship between Genotype and Phenotype

 Unit 3: Seminar Sickle Cell Anemia. Types of Biomolecules Figure 2-17 Molecular Biology of the Cell (© Garland Science 2008)

Red Blood Cell Indices. Red blood cell indices :are measurement that describe the size and oxygen carrying protein (HB) content of red blood cells. The.

HAEMOGLOBIN.  The main function of the RBCs is to carry O2 to the tissues and to return carbon dioxide to the lungs. In order to achieve this function,

EXERCISE PHYSIOLOGY Movement (kinesiology):

Molecular Basis for Relationship between Genotype and Phenotype DNA RNA protein genotype function organism phenotype DNA sequence amino acid sequence transcription.

Molecular Basis for Relationship between Genotype and Phenotype DNA RNA protein genotype function organism phenotype DNA sequence amino acid sequence transcription.

طه Coordinator : Dr.Mohammad Mansi Co-coordinator: Dr. Samah Metwally.

Genetic Counseling for the Future

RYAN CLARK Professional football player for the Pittsburgh Steelers Playoff game at Denver Last time he played there, he had to leave the game at half.

Cellular Injury and Adaptation. Pathology -Morphology : gross and microscopic changes of cell and tissue -Use ancillary techniques as : Histochemical,immunohistochemical,

Overview  Introduction  Biological network data  Text mining  Gene Ontology  Expression data basics  Expression, text mining, and GO  Modules and.

Bachelor of Biomedical Science Department of Biological.

Tabuk University Tabuk University Faculty of Applied Medical Sciences Department Of Medical Lab. Technology 2 nd Year – Level 4 – AY

VIROLOGY Claude MUVUNYI M.D, Ph.D. Head of Microbiology Unit/NRL RBC.

Central Role of Physiology in the Professional Curriculum

Biochemistry Free For All

Curriculum Transformation

Introduction to Metabolism

Biomedical Therapies Foundation Standard 1: Academic Foundation

Biomedical Sciences Pathway

BIO 1014 Innovative Education--snaptutorial.com

BIO 1014Education for Service-- snaptutorial.com.

Virtual Tour of MD Curriculum Class of 2022

Academic Year 2015 – 2016 Autumn, Winter and Spring Quarters

Haemoglobin structure & function

Relationship between Genotype and Phenotype

Welcome to the AAMC Building Better Curriculum Webinar Series We will begin our presentation shortly. Topic: UA COMP Clerkship Curriculum: How.

Metabolic Regulation SBCH321

Introduction to Metabolism

Trisha Jenkins Discipline Leader - Human Biosciences

Relationship between Genotype and Phenotype

Relationship between Genotype and Phenotype

BCH 471 Biochemistry of Blood

Introduction to pathology

Presentation transcript:

Organ-System-Based Integration of Biochemistry: Cells Do It; Can We Do It as Well? Eric Niederhoffer Southern Illinois University School of Medicine nutrition informational macromolecules hemostasis/thrombosis cytoskeleton/extracellular matrix extracellular/intracellular communications bioenergetics/metabolism proteins/enzymes

Organ-System-Based Integration of Biochemistry Basic Sciences Clinical Sciences Y1 (Carbondale) Y2Y3 clerkships Y4 electives CRR SSB ERG HII C NB ERG Anatomy BSS Biochemistry Doctoring Genetics Histology Pharmacology Physiology PHP Doctoring Genetics Immunology Microbiology Neoplasia Pathology Pharmacology Radiology

CRR Unit Organization SAQs (mc, T/F, short answers) MU & EOU Exams (clinical scenarios) Familial hyperlipidemia nutrition/metabolism Genetics MC SOB MC Lifestyle MC CVD MC F&E MC Shock MC Collagen/anemia Nutrition Surfactant G proteins/ signal transduction Clinical markers G proteins/ signal transduction Electrolyte imbalance Cholesterol/lipoproteins/plaques/lipid processing SCD ASD PE COPD Arrhythmia MI PSGN CHF Hb gene/product/defect Glycolysis/2,3-BPG, PPP/GSH RBC structure HbO 2 /CO 2 ECM/proteases/antiproteases/  1AT Chem panels G proteins/signal transduction Coagulation/clinical markers Cardiac markers Amino acid processing/urea cycle Ion channels/membrane transport ATP production Overview of gene expression Ion channels/action potentials Thrombolytic agents Muscle contraction/energy production Filtration barrier Clinical markers Clinical markers/BNP

ePBLM Organization Sickle Cell Disease Red blood cells: structure and function, glycolysis (2,3-BPG), pentose phosphate pathway, glutathione Introduction to genetics (basic principles) Introduction to molecular biology of gene expression: transcription, translation, protein processing Hemoglobin structure: HbA (  2  2 ), HbF (  2  2 ), HbA 2 (  2  2 ), HbS; overview of hemoglobin function Complete blood count: RBC parameter (Hct, Hb content, MCV, MCHC) and WBCs Structure and function of the spleen Pathogenesis and natural history of sickle cell disease Introduction to child development: Denver development chart, normal milestones Introduction to immunology: cause of inflammation and pain (cytokines and phagocytes)

The Best and Worst at Times Best Features Integration with other disciplines/clinical medicine overlap/redundancy of topics clinical relevance low priority Worst Features Perceived orphan topics Competition with other disciplines Non-biochemistry resources