Early immune disorders induced by childhood obesity E Carolan, AH Hogan, D O’Shea.

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Presentation transcript:

Early immune disorders induced by childhood obesity E Carolan, AH Hogan, D O’Shea

Childhood obesity and the developing Immune System Childhood is an important time for immune system development Increased immune-mediated co-morbidities associated with childhood obesity observed These co-morbidities include: – Diabetes Mellitus – Asthma – Multiple Sclerosis There are preliminary reports of suboptimal vaccine response associated with obesity

Inflammation in Childhood Obesity Increased hsCRP concentration Increased pro-inflammatory cytokines – TNF-α/IL-6/IL-1β Increased Monocyte Chemoattractant Protein – Key protein for regulation of monocyte migration Decreased levels of insulin sensitizing adipokine, Adiponectin

Altered Immune Cell Populations Increased Monocyte concentrations – Activated populations that correspond to higher cardiovascular risk in adults Reduced Invariant Natural Killer T cells – This cell population is thought to play a pivotal role in metabolic regulation Macrophage infiltration into adipose tissue