GLUCAGON Presented By Daniel Vakili. Familiar Analogy.

Slides:

Advertisements

Similar presentations

Endocrine Module 1b. Pancreas Gland 6 ” long Horizontal Behind stomach Upper left abdominal quadrant Both endocrine & exocrine functions.

Advertisements

500X 1000X Name the organ from which these slides were prepared.

Glucose regulation HBS3A. Blood glucose Sugar travels in the blood as g_________, and is stored in liver and muscle as g__________. Glucose is important.

Metabolism of the whole organism Metabolic profiles of organs Metabolic conditions Blood glucose levels: 90 mg/dL Fuel reserves glucose triacylglycerols.

Hormonal control of circulating nutrients Overview: The need for glucose and nutrient homeostasis Interchange of nutrients / fuel stores Insulin:secretion.

Metabolism FOOD proteins sugars fats amino acids fatty acids simple sugars (glucose) muscle proteins liver glycogen fat lipids glucose.

Metabolism FOOD proteins sugars fats amino acids fatty acids simple sugars (glucose) muscle proteins liver glycogen fat lipids glucose.

Pancreas and glucose By Juliana Xie.

Homeostatic Control of Metabolism

Introduction to Homeostasis And Controlling Blood Glucose Levels.

Physiological role of insulin Release of insulin by beta cells –Response to elevated blood glucose level –Effects of insulin Somewhat global Major effects.

Regulating blood sugar. The Pancreas Medline Plus © 2008 Paul Billiet ODWSODWS.

Biological effects of GH Somatotropic –Growth and cell proliferation IGF-I mediated Metabolic –Direct action of GH IGF-I independent Many tissues All nutrients.

Endocrine Physiology PANCREAS Dr. Meg-angela Christi M. Amores.

Hormones and the regulation of blood glucose

1 Control, Coordination and Feedback. 2 Blood glucose control What is glucose? Why is glucose in the blood? Where does it come from? Where does it go?

Introduction: a general overview of the endocrine system.

What you do this lesson Copy all notes that appear in blue or green Red / White notes are for information and similar notes will be found in your monograph.

AP Biology Endocrine System Hormones. AP Biology  Why are hormones needed?  chemical messages from one body part to another  communication.

 By: Taylor Amenta, Lexi Cox, Grant Walters, Morgan Bradley.

The regulation of blood glucose Starter:  Write down as many things as you can think about that affect your blood sugar levels 04/10/2015.

Negative Feedback Regulation of the Secretion of Glucagon and Insulin Process Diagrams Step-by-Step Copyright © 2007 by John Wiley & Sons, Inc.

Regulating Blood Sugar Islets of Langerhans groups of cells in the pancreas beta cells produce insulin alpha cells produce glucagon.

Endocrine System Chemical Control: similar to nervous control, coordinate body processes by transmitting messages from one part of the body to another.

How is blood glucose regulated by negative feedback regulation? By hormones Made by endocrine gland- Pancreas.

Endocrine Block Glucose Homeostasis Dr. Usman Ghani.

ENDOCRINE PANCREAS. Anatomy Location Pancreatic Islets (of Langerhans) –Alpha cells –Beta cells –Delta cells –F-cells.

Pancreas Pancreas is a glandular organ located beneath the stomach in the abdominal cavity. Connected to the small intestine at the duodenum. Functions.

Responses of Cells to Environmental Influences By Kari Edge.

The control of blood sugar 1. Blood sugar levels are higher than normal after a meal is digested. 2.

Endocrine System Hormones & Homeostasis Regulation How we maintain homeostasis  nervous system nerve signals control body functions  endocrine system.

Energy Requirements Living tissue is maintained by constant expenditure of energy (ATP). ATP is Indirectly generated from –glucose, fatty acids, ketones,

Glucose Homeostasis By Dr. Sumbul Fatma.

Endocrine Physiology The Endocrine Pancreas. A triangular gland, which has both exocrine and endocrine cells, located behind the stomach Strategic location.

Endocrine Physiology The Endocrine Pancreas Dr. Khalid Al-Regaiey.

Hormones and Homeostasis. Homeostasis  Maintaining a stable internal environment despite unstable external conditions  Examples of systems with homeostasis.

Homeostasis Regulation of Blood Glucose. Homeostasis Animals possess a nervous system and a hormonal system that interact in order to maintain the constancy.

Control of Blood Glucose. Anatomy to Keep in Mind.

Homeostasis of blood sugar, breathing and blood pressure

Ch.21.3 Endocrine System Chemical Control: similar to nervous control, coordinate body processes by transmitting messages from one part of the body to.

Mindarie Senior College 3A/3B HUMAN BIOLOGICAL SCIENCE HOMEOSTASIS HOMEOSTATIC MECHANISMS.

Diabetes. The Food You Eat is Broken Down Into Glucose to Supply Energy to Your Cells.

GLUCAGON. Glucagon: is secreted when “Glucose is GONE” Peptide hormone made of 29 amino acids. MW: 3485 Has several functions that are dramatically opposite.

Regulating blood glucose levels

HOMEOSTASIS AND NEGATIVE FEEDBACK BLOOD GLUCOSE, INSULIN AND GLUCAGON.

Homeostasis Unit 5 Sophie Bevan. Objectives Outline the assignment requirements for M3 Explain the homeostatic mechanisms for blood glucose regulations.

 Normal blood glucose is ranging from mg/dl ( mmol/L).  This normal range is kept through the effect of pancreatic hormone insulin and.

Blood Sugar Regulation. Remember me!? Why does your body need this molecule? How is it used?

The Pancreas By Margaret Sheekey Histology of the Pancreas The pancreas is in the abdomen, just below the stomach It is to the right of the liver when.

Ch. 14 Part 7 Blood Glucose Regulation. Glucose Carbohydrates transported in blood as soluble molecule called GLUCOSE – Monosaccharide – Ring structure.

Endocrine Block Glucose Homeostasis Dr. Usman Ghani.

Blood Glucose, insulin and glucagon

Glucagon – A hormone from pancreas Lecture NO:1st BDS

The Endocrine Pancreas

Glucose Homeostasis By Dr. Sumbul Fatma.

The Endocrine System Pancreatic Islets

Homeostasis: Control of blood glucose

Regulating Blood Sugar

Metabolism of the whole organism Metabolic profiles of organs Metabolic conditions Blood glucose levels: 90 mg/dL Fuel reserves glucose triacylglycerols.

How the pancreas controls blood sugar levels

Endocrine System.

Hormonal Regulation of Carbohydrates

Insulin and Glucagon Kamilah Gonzalez.

Hormonal Regulation of Carbohydrates

Glucagon – A hormone from pancreas Lecture NO: 2nd MBBS

The Endocrine Pancreas

Presentation transcript:

GLUCAGON Presented By Daniel Vakili

Familiar Analogy

Glucagon Glucagon Receptor Target Tissue with stored glucose Glucose

Structure >29 amino acid polypeptide hormone >nonsteroid

Where does it come from? >Synthesized and secreted from alpha cells in the islets of langerhans in the pancreas. > Cleaved from proglucagon

Action >Raise Blood Sugar - Glycogenolysis - Gluconeogenesis >Target tissues - Liver, Muscle, Fat >Glucagon and Insulin are part of a feedback system that keep blood sugar at normal levels

Receptor G-Protein Coupled Receptor > Part of the GPCR Family >Heptahelical > Extracellular region binds to ligands > Intracellular region interacts with multi-subunit G- Protein

Receptor > Ligand activates > GDP-GTP > alpha subunit dissociates

cAMP: a secondary messenger cyclic adenosine monophosphate Glucagon-Receptor > G-proteins dissociate > α subunit-adenylate cyclase > cAMP > removes inhibitory subunit of PKA

Normal Blood Values Insulin and Glucagon normally keep plasma glucose >below 170mg/dl after a meal (absorptive state) >above 50mg/dl between meals(postabsorptive state)

Too Little Glucagon: Hypoglycemia > Symptoms: tremor, hunger, weakness, weakness, blurred vision, and mental confusion.

Too Much Glucagon: >Glucagonoma- tumor of alpha cells resulting in overproduction > Hyperglycemia > Ketoacidosis - fatty acids to Ketone bodies > Gluconeogenesis - Weight loss, anemia, ketoacidosis, diabetes mellitus.

Conclusion Glucagon is a hormone antagonist to insulin, signaling the release of glucose from storage into the blood through glycogenolysis and gluconeogenesis. Important for maintaining homeostasis.