GREEN CHEMISTRY: PROESA ® Technology to convert Biomass into Bio-based Chemicals Guido Ghisolfi

The Biorefinery Concept The biorefinery concept is analogous to today's petroleum refinery which produces fuels and chemicals from petroleum End Markets Fuels & Energy Chemicals & Polymers Feedstock Conversion Platform Feedstock Conversion Platform Advanced carbohydrates (cellulose and hemicellulose) Cellulosic sugars and lignin Petrochemical way one raw material Biorefinery way many raw materials

The Biorefinery Opportunity: Reality or Dream? Commodities and consumer goods from biomass Competing with oil Is it possible Common position of the industry: "Traditional biocommodities are too expensive […] and cellulosic sugar is far away from being at low capex and low opex."

The Biorefinery Opportunity: Reality or Dream?

The barrel of oil is replaced by the new biomass barrel! Sustainability of the Biorefinery: A Question of Energy Producing multiple products and integrating waste treatment, biorefineries can maximize the values derived from biomass feedstock and turn biomass processing into real opportunities. CELLULOSE ( %) EMICELLULOSE (15 – 35 %) LIGNIN (15 – 20 %) ASHES (5 – 15 %) CELLULOSE (35-50 %) EMICELLULOSE (15-35 %) LIGNIN (15-20 %) ASHES (5-15 %) Biofuels Biochemicals Biochemicals (Aromatics) Silica

The Conversion of Biomass opens up to a Wide Array of Applications Sugarcane bagasse CelluloseHemicelluloseLignin Textiles Detergents Chemical intermediates & Plastics Diapers Wheat straw Corn stover Wood chips Arundo Donax Ethanol

Beta Renewables: Sustainable Chemistry Our Partners: Beta Renewables is a joint venture created in October 2011 between Biochemtex and the American private investment firm TPG (Texas Pacific Group) with a capital of € 250 million. Novozymes, a Denmark-based world class biotech company, has recently acquired 10% share of Beta Renewables. The JV is the owner of the PROESA ® technology used to produce biofuels and chemical intermediates. It has invested in the construction of the world's first commercial scale plant in Crescentino (Italy) that will produce second generation ethanol. Beta Renewables develops global alliances and partnerships to license the PROESA ® technology.

Our R&D Center in Rivalta Scrivia, Italy 130+ dedicated staff Our Rivalta Scrivia (Piedmont, Italy) research facility is equipped with 4600 m 2 dedicated to fuels chemistry and technology from renewable resources and counts engineers, biotechnologists and chemists dedicated to R&D activities.

Development Timeline Scouting of Technologies Generation of key inventions Proof of UNIT OPERATION in the labs Pilot plant (1 t/d) construction & start-up (June 2009) Pilot plant operation & data gathering Plant flexibility test using multiple biomasses 2014 GranBio in Alagoas Start-up Q Crescentino Plant Start-up Crescentino Plant Cooperation Agreements with leading synthetic biology companies License Agreements Formation of Beta Renewables

PROESA ® Technology: The Sugar Platform Biomass SteamEnzyme Smart Cooking Viscosity Reduction & Hydrolysis Fermentable Sugars Enabling the production of price competitive and clean cellulosic sugars. PROESA ® Sugar Platform Benefits Readily integrated with biology pathways or catalytic conversion platforms to produce fuels or bio- chemicals. Flexibility in parameters and versatility in project solutions based on client needs.

Our Vision Contribute to a more sustainable use of our world’s resources; Using non-food biomass; Cost-effective with petroleum without subsidies. Our Business Model Licensing PROESA ® to ensure global deployment and faster uptake of the technology; Developing packaged solutions with our partners for their needs. Market Need Creating value for all stakeholders involved: from farmers to industrial players. Transforming Beta Renewables' Vision into a Sustainable Business

A Platform for Sustainability PROESA ® Technology for Cellulosic Sugars Production PROESA ® Technology Chemical & Biological Conversion Platform BIOCHEMICALS Fatty Alcohols, 1,4 BDO, Farnasene BIOPOLYMERS Lactic Acid, Acrylic Acid, Succinic Acid, Adipic Acid LIGNIN CHEMICALS Phenols, Benzene, Xylene, Terephthalic Acid Ethanol, Jet Fuel, Butanol BIOFUELS

Proesa ® Technology is our way to see the future!